Notice here in this study it was done on men with prostate cancer(reason for this it was surmised for quite a while that high test levels were a direct cause of prostate enlargement/cancer..they have since found that it is not at all, it is more the opposite, estrogen related). Anyway, this study shows that lowering sat fat intake and adding 30 gr. of flaxseed per day significantly lowered test levels. 30 gr. of flax by the way is a pretty decent amount, and many may not call this "low fat" at all.
Pilot Study of Dietary Fat Restriction and Flaxseed Supplementation in Men with Prostate Cancer Before Surgery: Exploring the Effects on Hormonal Levels, Prostate-specific Antigen, and Histopathologic Features
A lowfat (20% of kilocalories or less), flaxseed supplemented (30 g/day) diet was ingested by 25 patients with prostate cancer awaiting prostatectomy for an average of 34 days (21 to 77 days). The baseline and follow-up levels of prostate specific antigen, testosterone, free androgen index, and total serum cholesterol were determined. The tumors of patients on the test diet were compared with those of historic cases. Significant decreases were observed in total serum cholesterol (201 +/ 39 mg/dL to 174 +/ 42 mg/dL), total testosterone (422 +/ 122 ng/dL to 360 +/ 128 ng/dL), and free androgen index (36.3%+/ 18.9% to 29.3%+/ 16.8%) (all P <0.05). The baseline and follow-up levels of prostate-specific antigen were 8.1 +/- 5.2 ng/mL and 8.5 +/-7.7 ng/mL, respectively, for the entire sample (P = 0.58); among men with Gleason sums of 6 or less (n = 19), the PSA values were 7.1 +/3.9 ng/mL and 6.4 +/4.1 ng/mL (P = 0.10). The mean proliferation index was 7.4 +/7.8 for the historic controls versus 5.0 +/4.9 for the diet treated patients (P = 0.05). Both the proliferation rate and apoptosis were significantly associated with the number of days on the diet (P = 0.049 and P = 0.017, respectively). The authors recommend further studies to determine the benefit of this dietary regimen on prostate cancer biology and associated biomarkers.
Authors: Demark-Wahnefried W, Price DT, Polascik TJ, Robertson CN, Anderson EE, Paulson DF, Walther PJ, Gannon M, Vollmer RT.
Source: Urology. Vol 58, no. 1: 47-52, July 2001.