Curious about EFA's

[anthrax]

No, they actually soothe inflammation
Also, MrMak mentioned that fish oils compete for phospholipdation at increased dosages. With what? By antogonizing AA(what's that)? and can it be alleviated by, say, SAMe?

But aspirin has been shown to inhibit prostaglandin synthesis which is why it reducies fever and inflammation, no ?

 

[juve]

that's why aspirin is an alternative to steroidal anti-infl medical aids. prostagladin=steroidal, aspirin=non-steroidal, how exactly it alleviates pain I don't know - never was curious enough to inquire

MrMak: arachnidoic acid maybe? if there's anarchic acid in the body, that's damn cool - anarchy!!!!

 

[MrMakaveli]

that's why aspirin is an alternative to steroidal anti-infl medical aids. prostagladin=steroidal, aspirin=non-steroidal, how exactly it alleviates pain I don't know - never was curious enough to inquire

MrMak: arachnidoic acid maybe? if there's anarchic acid in the body, that's damn cool - anarchy!!!!

lol! yeah your right, I still need to sleep today, fucking school.

 

[MrMakaveli]

Allerg Immunol (Paris) (FRANCE) Oct 1987, 19 (8 Suppl) p12-3

The arachidonic acid substitution by an alternative fatty acid, substrate for the 5-lipoxygenase and the cyclo-oxygenase pathway constitutes a novel therapeutic approach or a complement for other therapeutics in the inflammation area. Eicosapentaenoic acid (EPA), one of the fish oil components, is a substrate for both enzymes and an inhibitor for several enzymes of arachidonic acid cascade, in vitro and in vivo. The EPA-generated metabolites have less pro-inflammatory effects than those produced by arachidonic acid metabolism.

 

[ProtienFiend]

No, olive oil is primarily monounsatured (n-9), with traces of n-6 and n-3 fats (with more n-6 than n-3).

My advice is to go with 4-6 grams of fish oil a day and 4 tbs of flax seed oil to provide your n-3 fats, although going alot higher on the flax can be beneficial depending on your individual diet and goals. Do not worry about adding n-6 fats to your diet. You are probably gettting more than enough already.

thats why im sticking to canola... its mostly omega-3's... and cheaper than both fish and flax... fish is more beneficial because of the EPA content

 

[MrMakaveli]

Allerg Immunol (Paris) (FRANCE) Oct 1987, 19 (8 Suppl) p12-3

The arachidonic acid substitution by an alternative fatty acid, substrate for the 5-lipoxygenase and the cyclo-oxygenase pathway constitutes a novel therapeutic approach or a complement for other therapeutics in the inflammation area. Eicosapentaenoic acid (EPA), one of the fish oil components, is a substrate for both enzymes and an inhibitor for several enzymes of arachidonic acid cascade, in vitro and in vivo. The EPA-generated metabolites have less pro-inflammatory effects than those produced by arachidonic acid metabolism.

This is where literature gets confusing. One study shows EPA alone can significantly increase AA levels while there are many that show that it can supress it as well. I think regardelss Fish oil is a great choice for fat intake.

 

[juve]

This is where literature gets confusing. One study shows EPA alone can significantly increase AA levels while there are many that show that it can supress it as well. I think regardelss Fish oil is a great choice for fat intake.

That's what I was thinking initially, that by suppressin arachnidoic acid fish oil actually stimulates anit-inflammatory and protein preserving processes as is pointed in the abstract you provided.


OT: Canola oil is primarily o-6's, very little o-3

 

[ProtienFiend]

????
3tbsp of fish oil=42g's of..... fish oil, haha
I get it at GNC - $9~ for 16oz bottle.

42 g's a day?

i hope you are using "natural" fish (i think they are alaskan)... the bred ones are known to have certain toxins and such (ie mercury...)

 

[anthrax]

OK, I think I eventually got it :

PGE1 and PGE3 = anti-inflammatory prostaglandins
whereas Excess levels of prostaglandin E2 (PGE2) can cause inflammation

 

[MrMakaveli]

OK, I think I eventually got it :

PGE1 and PGE3 = anti-inflammatory prostaglandins
whereas Excess levels of prostaglandin E2 (PGE2) can cause inflammation

Persactly

On a side not apparently leptin expression is also related to inflammation hence why leptin is lowered with the use of fish oils (although fat-loss also plays a role)