How much does Anavar help with ligaments and tendon building?

[tommboy]

As mentioned above. I have partially torn my right and left bicep tendons.
When one was healing I used deca for ten weeks and var for 6 weeks. I also used 2iu's of gh a day for 5 months.
The other I used nothing.
I had serious complications with the one that I used AAS and GH with. The other healed in half the time with no "supplementation".
When I used AAS it felt better but it was really in worse condition.
My Dr. looked at the MRI's and flat out told me to get off what ever I was on as it was "fucking up my arm and its recovery".
Due to that conversation I never used anything with my other arm. It has healed in half the time. No real scar tissue (as compared to the other arm) and no adema.

But can we totally be for sure because your recovery was hurt from AAS use that others might not be able to heal with/from it ?

 

[Agent Dana Scully]

Would it be wise to take Glucosamine with var or with winny?

 

[dezza6969]

Study that supports anavars affects on collagen synthesis:

In vivo, there are reported increases in wound breaking strength with anabolic steroid therapy, including oxandrolone. [1,5,12] During the early stages of gain in wound breaking strength of healing incisional wounds, there is increased deposition of new collagen. These studies support the notion that oxandrolone enhances the deposition of collagen in wounds by directly increasing the expression of both type III and type I procollagen mRNA. The relevance of these observations to the clinical setting may be described by the following scenario. Oxandrolone has been shown to facilitate weight gain in patients with weight loss and pressure ulcers. [7] Oxandrolone increases nitrogen retention, enhancing protein synthesis. [19] As weight is restored and protein reserves are repleted, wound closure ensues. [7] Along with this systemic response, evidence is mounting for a possible direct effect of oxandrolone on wounds. This is shown by the increased collagen cellularity and tensile strength described in vivo, [1,12] the mechanism of which may be the increased expression of collagen on the cellular level, presented here.

The full article at http://www.medscape.com/viewarticle/403338_4

 

[searay]

^^^ur article says nothing about tendons. considering the negative impact on hdl/ldl levels from using anavar and any oral for that matter i dont think it makes any sense to use it to speed up or prevent damage to tendons when there are are other choices with much less side effects. i have to agree with anthony for once on this matter. i do agree that equi and deca do have the ability to increase collagen synthesis but to the degree it can prevent injury i think it has very little impact. someone made the comment that the pros never get hurt. are you kidding us or what? there was at least 3 top level contestants that were out of the last olympia due to some sort of injury that from what i remember had to do with tendons. ur tendons are just not going to keep up with the type of strength gains you can make using aas unless maybe you run high doses of equi and gh alone and use light weight high rep work for about a year. then maybe just maybe your tendosn will have kept pace with your strenth gains. anavar is a great drug, one of the best orals as far as im concerned, but to use it for tendon strenth is not a good idea to put it mildly. as far as its use for children has nothing to do with its ability to increase tendon strenth and evrything to do with its ability NOT to fuse growth plates. just my 2 cc's....................

 

[dezza6969]

^^^ur article says nothing about tendons. impact on hdl/ldl levels from using anavar and any oral for ons. considering the negative that matter i dont think it makes any sense to use it to speed up or prevent damage to tendons when there are are other choices with much less side effects. i have to agree with anthony for once on this matter. i do agree that equi and deca do have the ability to increase collagen synthesis but to the degree it can prevent injury i think it has very little impact. someone made the comment that the pros never get hurt. are you kidding us or what? there was at least 3 top level contestants that were out of the last olympia due to some sort of injury that from what i remember had to do with tendons. ur tendons are just not going to keep up with the type of strength gains you can make using aas unless maybe you run high doses of equi and gh alone and use light weight high rep work for about a year. then maybe just maybe your tendosn will have kept pace with your strenth gains. anavar is a great drug, one of the best orals as far as im concerned, but to use it for tendon strenth is not a good idea to put it mildly. as far as its use for children has nothing to do with its ability to increase tendon strenth and evrything to do with its ability NOT to fuse growth plates. just my 2 cc's....................

I only just saw this reply. Mate how does it say nothing about tendons? It expresses that oxandrolone increases collagen synthesis. Collagen synthesis is vital in tendon repair.

Let me go through this article, as always medical publications are not the most clear-cut publications that can be speed read, as I'm sure you did.

Okay this study involved human fibroblasts grown on both plastic and collagen. Just to give you wikipedia's definition of a fibroblast:
'A fibroblast is a type of cell that synthesizes the extracellular matrix and collagen, the structural framework (stroma) for animal tissues, and play a critical role in wound healing. They are the most common cells of connective tissue in animals.'

So as they are the most common cells in connective tissue we can see this study is relevant to tendons. Alright to proceed, and this is where you might have thought the article had no merit, where the article discusses fibroblasts grown on plastic-
'Oxandrolone has no effect upon the expression of procollagen types I and III mRNA in human dermal fibroblasts growing on plastic.' (these procollagen mRNAs' are precursors to collagen synthesis) but the article goes onto say that fibroblasts on plastic have procollagen mRNA levels that are 'near maximal levels' anyway. This is because 'Fibroblasts growing on plastic have characteristics like fibroblasts during early wound healing, when these cells are associated with an environment rich in fibrin and serum.' So because plastic represents an environment in the early stages of a wound eg:tear to a tendon, oxandrolone supplementation will not be useful because collagen synthesis apears to be at maximal levels anyway.

But, in the fibroblasts grown on collagen
'The addition of oxandrolone to fibroblasts growing on collagen enhances the expression of procollagen mRNA to levels equivalent to that of fibroblasts maintained on plastic. The expression of type III procollagen mRNA is stimulated 11-fold by oxandrolone in fibroblasts grown on collagen.' So if fibroblasts grown on plastic exert near maximal collagen synthesis{procollagen mRNA levels}(representing the early stages of a wound when collagen synthesis is most needed) and fibroblasts grown on collagen (representing tendon or tissue in its normal or post damage state, not a fibrin and serum rich environment as in early stages of wound) exposed to oxandrolone show procollagen mRNA levels the equivalent to fibroblasts grown on platic, then it is clear that oxandrolone can help strengthen connective tissue. Although it will have no effect on a tear in early stages it will increase collagen synthesis at any other time.

Also here is another point put forward by the study speculating on the differences between the fibroblasts on plastic ad collagen
'Anabolic steroids are derived from a chemical modification of testosterone and exert their effect by binding to androgen receptors. The cell surface of dermal fibroblasts contains a high density of these receptors.[23]The binding of anabolic steroid to these receptors increases anabolic activity, including the synthesis of proteins. One possibility is that fibroblasts growing on plastic make more collagen, but express fewer anabolic steroid receptors on their surface compared to fibroblasts growing on collagen. Fibroblasts growing on collagen synthesize less collagen and express more anabolic steroid receptors. Hence, fibroblasts growing on plastic are less responsive to anabolic steroids in comparison to the same cells growing on collagen. By Northern plot analysis, oxandrolone enhances the expression of mRNA specific for a1(I) and a1(III) procollagen chains, in fibroblasts residing on a collagen matrix.'

I'm just putting forward what I found in that publication, I'm sure others can come forward and shed some more light on it more accurately than i can. but i think simply saying 'ur article says nothing about tendons' is pretty ignorant, but if you glanced at the article for two-seconds is understandable.

See the link for this article on my last post.

Also check out:

Nutrition and wound healing - Google Books

Scroll down to the header entitled 'Wound Healing Properties'

Cheers