Yes, theride, you do get less of the drug with oral administration.
This is due to the "first pass effect", which means that everything you eat (pills, food etc.) goes directly to the liver before reaching any other part of the body.
This is to your benefit in that your liver detoxifies things before they can reach the body's more sensitive tissues.
By injecting intramuscularly, you bypass the liver's powerful action and get more of the drug to your muscles than if you took the same dose by the oral route. The liver degrades the drug at a much slower rate, because the drug is coming from the muscle you injected, not the gastrointestinal tract.
Just look up "first pass metabolism" on Google and you will see the benefits of parenteral, or injectable drugs as opposed to oral administration.
This is due to the "first pass effect", which means that everything you eat (pills, food etc.) goes directly to the liver before reaching any other part of the body.
This is to your benefit in that your liver detoxifies things before they can reach the body's more sensitive tissues.
By injecting intramuscularly, you bypass the liver's powerful action and get more of the drug to your muscles than if you took the same dose by the oral route. The liver degrades the drug at a much slower rate, because the drug is coming from the muscle you injected, not the gastrointestinal tract.
Just look up "first pass metabolism" on Google and you will see the benefits of parenteral, or injectable drugs as opposed to oral administration.