I had my IGF-1 levels checked 2 weeks ago and they were 386 compared to 90 to 360 ng/ml but I'm 54 and lowered my dose before blood test. When I first started HGH about 3 months later my left wrist would hurt me and that went on for about 4 months. Then it went away.I've been on HGH for 3½years and for everything I'd say about it ,it's the greatest thing ever. I've got the thicken of skin and good fat loss (althou my diet is great) and I can say that I don't have huge bulging muscles ,their still big. As far as aging goes, people that know me say I have'nt gotten older,have no sign of wrinkles, no sagging eyes,firmer skin,healthy glow about me and regardless of what I say of this board ,my mind is sharp and better then ever. To think that I had a stroke 6 years ago too. I'm on the road to recovery and there's no stopping me now,so put that in your Funk and Wagnalls.