SPAT
You're making the assumption that normal stress = upregulation of HSD-1 in adipose tissue. Is there a paper out there that shows that?
The rats in the Harvard study also exhibited leptin resistance, increased circulating TNF-beta and increased portal vein cortisol levels. Does normal stress cause this as well?
Normal stress may increase circulating cortisol, but obese individuals don't have increased circulating cortisol and the Masuzaki study suggests increase adipocyte cortisol concentration as the key player in the metabolic syndrome, not circulating cortisol that would be a consequence of stress. So...........Where's the connection?
Stress if that is really the problem here may drive an out-of-control appetite even though CRF has appetite supressing effects. None-the-less, I have yet to meet a female that doesn't overeat or carb binge when stressed. In addition her eating habits may just be poor. With kids, mothers tend to eat what the kids don't or eat with them and then again later. More food = fat.
My guess is that there is too much food intake and not enough physical activity.
W6