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napsgear
genezapharmateuticals
domestic-supply
puritysourcelabs
RESEARCHSARMSUGFREAKeudomestic
napsgeargenezapharmateuticals domestic-supplypuritysourcelabsRESEARCHSARMSUGFREAKeudomestic

Walking or running to burn most calories???

5'5 and 110??? that is waaay thin, that would involve having very little muscle...

best for her to work on weight training and diet to burn fat, and go by how she fits in her clothes...not a number!!!
 
SPAT

You're making the assumption that normal stress = upregulation of HSD-1 in adipose tissue. Is there a paper out there that shows that?

The rats in the Harvard study also exhibited leptin resistance, increased circulating TNF-beta and increased portal vein cortisol levels. Does normal stress cause this as well?

Normal stress may increase circulating cortisol, but obese individuals don't have increased circulating cortisol and the Masuzaki study suggests increase adipocyte cortisol concentration as the key player in the metabolic syndrome, not circulating cortisol that would be a consequence of stress. So...........Where's the connection?

Stress if that is really the problem here may drive an out-of-control appetite even though CRF has appetite supressing effects. None-the-less, I have yet to meet a female that doesn't overeat or carb binge when stressed. In addition her eating habits may just be poor. With kids, mothers tend to eat what the kids don't or eat with them and then again later. More food = fat.

My guess is that there is too much food intake and not enough physical activity.

W6
 
Q -

Either have your wife read or print out for her the stickies on the top of this board - you probably dont' need the ones about AS, but there are some great ones about the myths of women lifting, cardio, etc. Let your wife read these and see if she sees the light about training & diet. So many people are in denial about their diets and are scared of training or dont' see it as something they should do every day w/ intensity because of lack of knowledge about how the body works. It doesnt' have to be something painful, just apply some common sense with a little info (NOT from the Jenny Craig commercials) about nutrition and work out something that fits her lifestyle and she should see not only positive gains (meaning weight & fat loss) but also a reduction in her stress & just generally feeling better and more energetic!

BTW - I agree - 110 lbs at 5'5" is WAAAAAAY too skinny. Something like 120-130 is more reasonable I think - but what should matter more is how your wife looks and feels about herself.
 
smoknjilly said:
5'5 and 110??? that is waaay thin, that would involve having very little muscle...

best for her to work on weight training and diet to burn fat, and go by how she fits in her clothes...not a number!!!

Amen. My 120 pound butt is several inches SMALLER than my 110 pound butt. Get her thinking about body composition and lean mass, not a number on the scale.
 
Nothing is for sure SPAT, but I've never read anything that suggests that insulin is lipolytic, ever. Just about all the glycolytic/gluconeogenic; glycogenolytic/glycogenic; lipolytic/lipogenic enzymes and pathways depend on the insulin/glucacon ratio. It takes only a very small increase in insulin to shut down lipolysis except during exercise. It all depends on whether you're in a fed or fasted stated. Exercise being somewhat of an exception in that you still oxidize a significant amount of fat even when consuming a carbohydrate drink during prolonged exercise.

Cortisol is different. Decreases protein synthesis in most tissue except the liver where it increases it. Cortisol does increase lipolysis but also increases visceral fat deposits, so it does both.

That HSD-1 paper in Science got me thinking about why recovering anorexics deposit fat more centrally, even with estrogen supplementation. The cortisol hypothesis was suggested but the circulating hypothesis didn't fit. Now I'm wondering if anorexics for whatever reason flip on the HSD-1 gene switch and that predisposes them to more central/abdominal fat regain because of increased adipocyte cortisol. Moreover, in that study because of the leptin insensitivity I'm wondering if HSD-1 is upregulated in other tissue and perhaps the brain as well. Hmmmmm........Another reason not to develop an eating disorder.

W6
 
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I wonder if the urinary free cortisol elevation is all of adrenal origin. There is certainly something going on with cortisol and central fat accumulation.

W6
 
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