Please Scroll Down to See Forums Below 
MonStar1023
New member
Ill be stacking Adipo + T2 in a few weeks.. well see what happens.
BioTest T2-just started using it
- Thread starter fhg43
- Start date
MonStar1023
New member
Biotest T2
50 mcg of 3;5-diiodo-l-thyronine
Even though T2 (3,5-diiodo-L-thyronine) is potentially suppressive if used long-term, it's still very safe when used at the recommended doses for periods of up to six weeks. But after that, to avoid the possibility of TSH suppression, you need to cycle off for six weeks In other words, it's not going to down-regulate thyroid production and leave your gland as inactive as a dormant volcano after you stop using it as long as you cycle off T2 for 6 weeks after 6 weeks of use.
This is almost too good to be true! Now we can have all the metabolic stimulating horsepower of T3 in a safe dietary supplement. In fact, with all the volumes of research on T2 ?Eas well as searching the FDA's archives ?Ethere isn't one single case of an adverse reaction reported from its use.
Now that we've covered the safety issue, it's time to get into what's really exciting about T2.
T2 is found abundantly in beef - you know, steak, hamburger, etc. - which clearly establishes that it's in our food supply and passes the FDA's supplement test. Our T2 isn't made from ground chuck, mind you, so don't freak out. It's highly pure material made in a pharmaceutical lab.
If you're unfamiliar with T3, it's what the hardcore bodybuilders use in the final stages of contest prep to help them get that cellophane-thin skin that everyone wants, but few can obtain. In other words, without T3, most competitive bodybuilders would have an entirely different look, smoother to say the least. Of course, there are the select few who wouldn't need T3, but they are the rare exceptions.
Ever since the super ripped look first appeared in the 80s, T3 has been widespread and universally used by the hardcore guys. But this leaves most of us law-abiding blokes pressing our noses against the metabolic windowpane, looking in at the privileged few who have access to T3.
Yes, we have brand-new, cutting-edge thermogenics like MD6, but they only address half the metabolic challenge of getting lean, which is primarily through adrenoreceptor regulation.
For example, MD6 contains compounds that effectively target both alpha and beta adrenoreceptors, control appetite even for the most avid gluttons (me), and elevate mood, making you as perky as Kathie Lee on speed. But, it doesn't provide the ability to switch on the body's real thermogenic powerhouses?Ethyroid receptors and the mitochondria.
(In case you slept through biology class, like me, mitochondria are little critters that supply most of the aerobic fuel (ATP) for cells. In other words, activate them and you'll increase the metabolism, big time!)
The Other Mr. T
When we use the term "T," most often we're referring to Testosterone. But there's another powerful chemical family with that beloved moniker ?EThyroid hormones.
Thyroid hormones (TH) are considered major tissue growth factors. In fact, without them, overall body growth would not occur. They effect the activity of enzymes, the metabolism of substrates, vitamins and minerals, and the function of other endocrine systems.
In essence, thyroid hormones stimulate basal metabolic rate by increasing whole-body oxygen consumption, which is activated through two different pathways: DNA transcription on various target tissues (heart, liver, muscle, etc.), and by acting directly upon the mitochondria.
The effect on the mitochondria is particularly interesting. Even though the mechanism isn't fully understood, it's believed thyroid hormones act as uncoupling agents, releasing energy through the production of ATP.
Additionally, thyroid hormones?E
Stimulate protein synthesis (Can you say Anabolic!?)
Affect most every aspect of carbohydrate metabolism
Produce multiple effects on lipid metabolism, especially lipoproteins ("cholesterol")
Enhance the effects of epinephrine in stimulating glycogenolysis and glucose utilization
As you can see, thyroid hormones are powerful metabolic allies to have on your side. And, in contrast, if you're thyroid deficient, you're dead meat, bubba.
In today's world, with all the crazy dieting schemes and thermogenic compounds being used by just about everyone, it's a safe bet that most of our T glands are a little sluggish. But that doesn't have to be the case. Now we have a legal, as well as safe, over-the-counter thyroid hormone with just as much punch as the big guy himself, T3. Of course, the thyroid hormone I'm referring to is T2.
And just because 2 is one less than 3, don't let that fool you. Remember, T4 is much weaker than T3, so the number scheme doesn't reflect the potency of the analogue.
All this is pretty cool stuff, but how does T2 actually stack up to T3? Ready to be very impressed?
T2 Compared to T3
The similarity between T2 and T3 is remarkable ?Eboth in structure as well as activity in the body. Just take a look at the respective chemical names:
T2: diiodothyronine (3,5-diiodo-l-thyronine)
T3: triiodothyronine (3,5,3'-triiodo-l-thyronine)
Not a chem buff? That's okay, there's tons of scientific literature that compares the actions of T2 to T3. When I began to delve into the research, the more I read about T2 the more excited I became. In fact, I'm so impressed with T2, I don't plan on using T3 ever again. And, if what follows doesn't give you wood, nothing will. Here's what I found:
T2 is as effective as T3 at activating hepatic malic enzyme (ME), but it's 3-5 times more effective at activating liver glucose-6-phosphate dehydrogenase (G6PD).
T2 has much more of a pronounced effect on the mitochondria than T3 on four metabolically very active tissues: brown-adipose tissue, skeletal muscle, the liver, and heart muscle.
T2 boosts GH identical to T3, which is a 5-fold increase (demonstrated in hypothyroid rats).
T2 directly targets cytochrome-C reducers and cytochrome-C oxidizers, thus significantly stimulating mitochondrial respiration. This means T2 plays a role where rapid-energy utilization is required, such as cold exposure or overfeeding (pigging out).
Bottom line is, T2 is every bit as potent as T3, which means you now have an over-the-counter supplement that can truly maximize actual thyroid function just as effectively as the prescription drug Cytomel (T3)! And Biotest is the one delivering it, which makes us feel pretty darn good.
We've made a commitment to produce products that work nearly as well, or as well, as the popular, illegal drugs of bodybuilding. And with T2, we hit the "as good as drugs" category.
Biotest T2 is, without a doubt, the single, most-potent compound for fat loss ever to be released in the supplement industry. In fact, it's so effective that we have concerns about what the FDA's going to do. Yes, we have attorneys who have given us the go-ahead, but you know the FDA?EIt's their way or the highway.
Getting Truly Lean and Buff
This is where I give a strong dose of reality. If you're as fat as a manatee, don't expect to take T2 and be able to do ab poses at the beach in a week. It should be obvious, the further you are away from being ripped, the longer it's going to take to get there.
To put it in perspective, if you have 20 pounds of fat to lose ?Ethe basic 2-pack look ?Eyou better know that it's going to take at least two months to get super lean, that is if you have the genetics, and if you don't metabolize a bunch of muscle in the process.
To get truly lean, you have to make a commitment to pay careful attention to manipulating diet and post-workout nutrition, tweaking training, and using drugs and/or supplements that accelerate fat loss and maximize muscle gains.
Don't misunderstand me. I'm not saying that you should expect to gain a lot of muscle while cutting up. All I'm saying is that you have to use anabolic agents at this time to preserve muscle mass, and maybe even gain a pound or two. In other words, regarding your physique, getting exceptionally lean is probably the single most difficult endeavor you'll encounter.
I'm convinced that it's utterly impossible to get really lean and buff without the use of powerful compounds to rev up the metabolism, and anabolics to keep from losing muscle mass. If purebred bodybuilders have to do it that way, we do too.
So, in your quest for cellophane-thin skin, don't forget to include anabolics. In the steroid world, in my opinion, we're talking about trenbolone acetate, stanozolol, oxandrolone, and injectable 4-AD. And for those who want to stay legal, the best choices are Androsol, Nandrosol, Tribex-500, and Methoxy-7.
In summary, to get that ripped, muscular-hard look of a bodybuilder, you need to stack a potent adrenoreceptor thermogenic, like MD6, with T2 and anabolics. Without this super-stack arsenal, don't expect these kinds of results. You can get lean, but not that lean.
50 mcg of 3;5-diiodo-l-thyronine
Even though T2 (3,5-diiodo-L-thyronine) is potentially suppressive if used long-term, it's still very safe when used at the recommended doses for periods of up to six weeks. But after that, to avoid the possibility of TSH suppression, you need to cycle off for six weeks In other words, it's not going to down-regulate thyroid production and leave your gland as inactive as a dormant volcano after you stop using it as long as you cycle off T2 for 6 weeks after 6 weeks of use.
This is almost too good to be true! Now we can have all the metabolic stimulating horsepower of T3 in a safe dietary supplement. In fact, with all the volumes of research on T2 ?Eas well as searching the FDA's archives ?Ethere isn't one single case of an adverse reaction reported from its use.
Now that we've covered the safety issue, it's time to get into what's really exciting about T2.
T2 is found abundantly in beef - you know, steak, hamburger, etc. - which clearly establishes that it's in our food supply and passes the FDA's supplement test. Our T2 isn't made from ground chuck, mind you, so don't freak out. It's highly pure material made in a pharmaceutical lab.
If you're unfamiliar with T3, it's what the hardcore bodybuilders use in the final stages of contest prep to help them get that cellophane-thin skin that everyone wants, but few can obtain. In other words, without T3, most competitive bodybuilders would have an entirely different look, smoother to say the least. Of course, there are the select few who wouldn't need T3, but they are the rare exceptions.
Ever since the super ripped look first appeared in the 80s, T3 has been widespread and universally used by the hardcore guys. But this leaves most of us law-abiding blokes pressing our noses against the metabolic windowpane, looking in at the privileged few who have access to T3.
Yes, we have brand-new, cutting-edge thermogenics like MD6, but they only address half the metabolic challenge of getting lean, which is primarily through adrenoreceptor regulation.
For example, MD6 contains compounds that effectively target both alpha and beta adrenoreceptors, control appetite even for the most avid gluttons (me), and elevate mood, making you as perky as Kathie Lee on speed. But, it doesn't provide the ability to switch on the body's real thermogenic powerhouses?Ethyroid receptors and the mitochondria.
(In case you slept through biology class, like me, mitochondria are little critters that supply most of the aerobic fuel (ATP) for cells. In other words, activate them and you'll increase the metabolism, big time!)
The Other Mr. T
When we use the term "T," most often we're referring to Testosterone. But there's another powerful chemical family with that beloved moniker ?EThyroid hormones.
Thyroid hormones (TH) are considered major tissue growth factors. In fact, without them, overall body growth would not occur. They effect the activity of enzymes, the metabolism of substrates, vitamins and minerals, and the function of other endocrine systems.
In essence, thyroid hormones stimulate basal metabolic rate by increasing whole-body oxygen consumption, which is activated through two different pathways: DNA transcription on various target tissues (heart, liver, muscle, etc.), and by acting directly upon the mitochondria.
The effect on the mitochondria is particularly interesting. Even though the mechanism isn't fully understood, it's believed thyroid hormones act as uncoupling agents, releasing energy through the production of ATP.
Additionally, thyroid hormones?E
Stimulate protein synthesis (Can you say Anabolic!?)
Affect most every aspect of carbohydrate metabolism
Produce multiple effects on lipid metabolism, especially lipoproteins ("cholesterol")
Enhance the effects of epinephrine in stimulating glycogenolysis and glucose utilization
As you can see, thyroid hormones are powerful metabolic allies to have on your side. And, in contrast, if you're thyroid deficient, you're dead meat, bubba.
In today's world, with all the crazy dieting schemes and thermogenic compounds being used by just about everyone, it's a safe bet that most of our T glands are a little sluggish. But that doesn't have to be the case. Now we have a legal, as well as safe, over-the-counter thyroid hormone with just as much punch as the big guy himself, T3. Of course, the thyroid hormone I'm referring to is T2.
And just because 2 is one less than 3, don't let that fool you. Remember, T4 is much weaker than T3, so the number scheme doesn't reflect the potency of the analogue.
All this is pretty cool stuff, but how does T2 actually stack up to T3? Ready to be very impressed?
T2 Compared to T3
The similarity between T2 and T3 is remarkable ?Eboth in structure as well as activity in the body. Just take a look at the respective chemical names:
T2: diiodothyronine (3,5-diiodo-l-thyronine)
T3: triiodothyronine (3,5,3'-triiodo-l-thyronine)
Not a chem buff? That's okay, there's tons of scientific literature that compares the actions of T2 to T3. When I began to delve into the research, the more I read about T2 the more excited I became. In fact, I'm so impressed with T2, I don't plan on using T3 ever again. And, if what follows doesn't give you wood, nothing will. Here's what I found:
T2 is as effective as T3 at activating hepatic malic enzyme (ME), but it's 3-5 times more effective at activating liver glucose-6-phosphate dehydrogenase (G6PD).
T2 has much more of a pronounced effect on the mitochondria than T3 on four metabolically very active tissues: brown-adipose tissue, skeletal muscle, the liver, and heart muscle.
T2 boosts GH identical to T3, which is a 5-fold increase (demonstrated in hypothyroid rats).
T2 directly targets cytochrome-C reducers and cytochrome-C oxidizers, thus significantly stimulating mitochondrial respiration. This means T2 plays a role where rapid-energy utilization is required, such as cold exposure or overfeeding (pigging out).
Bottom line is, T2 is every bit as potent as T3, which means you now have an over-the-counter supplement that can truly maximize actual thyroid function just as effectively as the prescription drug Cytomel (T3)! And Biotest is the one delivering it, which makes us feel pretty darn good.
We've made a commitment to produce products that work nearly as well, or as well, as the popular, illegal drugs of bodybuilding. And with T2, we hit the "as good as drugs" category.
Biotest T2 is, without a doubt, the single, most-potent compound for fat loss ever to be released in the supplement industry. In fact, it's so effective that we have concerns about what the FDA's going to do. Yes, we have attorneys who have given us the go-ahead, but you know the FDA?EIt's their way or the highway.
Getting Truly Lean and Buff
This is where I give a strong dose of reality. If you're as fat as a manatee, don't expect to take T2 and be able to do ab poses at the beach in a week. It should be obvious, the further you are away from being ripped, the longer it's going to take to get there.
To put it in perspective, if you have 20 pounds of fat to lose ?Ethe basic 2-pack look ?Eyou better know that it's going to take at least two months to get super lean, that is if you have the genetics, and if you don't metabolize a bunch of muscle in the process.
To get truly lean, you have to make a commitment to pay careful attention to manipulating diet and post-workout nutrition, tweaking training, and using drugs and/or supplements that accelerate fat loss and maximize muscle gains.
Don't misunderstand me. I'm not saying that you should expect to gain a lot of muscle while cutting up. All I'm saying is that you have to use anabolic agents at this time to preserve muscle mass, and maybe even gain a pound or two. In other words, regarding your physique, getting exceptionally lean is probably the single most difficult endeavor you'll encounter.
I'm convinced that it's utterly impossible to get really lean and buff without the use of powerful compounds to rev up the metabolism, and anabolics to keep from losing muscle mass. If purebred bodybuilders have to do it that way, we do too.
So, in your quest for cellophane-thin skin, don't forget to include anabolics. In the steroid world, in my opinion, we're talking about trenbolone acetate, stanozolol, oxandrolone, and injectable 4-AD. And for those who want to stay legal, the best choices are Androsol, Nandrosol, Tribex-500, and Methoxy-7.
In summary, to get that ripped, muscular-hard look of a bodybuilder, you need to stack a potent adrenoreceptor thermogenic, like MD6, with T2 and anabolics. Without this super-stack arsenal, don't expect these kinds of results. You can get lean, but not that lean.
MonStar1023
New member
This is quoted from a supplement company so I am not completely sure on how accurate what they say is in real-life.
fhg43
New member
Here is that link and below is the text:
http://musclemonthly.com/articles/010701-haycock-supplement-science.html
<<<The Scoop on T2 (3, 5-diiodo-1-thyronine)
Hey Bryan,
What is the scoop on this new T2 fat loss compound (3, 5-diiodo-1-thyronine)? The recommended dose is 50 mcg 1 to 3 times a day. The claims are:
"With T2, thyroid production is effectively increased at both the thyroid receptor site, as well as the mitochondria that are located in certain highly metabolic tissues."
"T2, on the other hand, on a mcg-to-mcg basis, is much less suppressive than T3, something on the order of 1%, meaning you'd have to take 100 times the amount of T2, as compared to T3, to get the same inhibition of TSH. At the same time, T2 is just as metabolically potent, and in some instances more potent than T3 — like with increasing hepatic oxygen consumption and uncoupling mitochondria."
"Bottom line with T2, it has every bit as much horsepower as T3, with minimal side effects. And if you follow the guidelines on the T2 label — 50 mcg 1-3 times a day for no longer than six weeks — you should have no problems after you discontinue use."
The scoop is that Diiodothyronine (T2) is an active iodothyronine very similar to T3. T2 is a metabolite of T3, yet it is metabolically active. I guess the best way to cover this particular question is to deal with the claims being made about T2.
First claim, "With T2, thyroid production is effectively increased at both the thyroid receptor site, as well as the mitochondria that are located in certain highly metabolic tissues."
This is false. Thyroid "production" is effectively decreased due to a reduction in both TSH and T4 levels with supplemental T2.
Second claim, "T2, on the other hand, on a mcg-to-mcg basis, is much less suppressive than T3, something on the order of 1%, meaning you'd have to take 100 times the amount of T2, as compared to T3, to get the same inhibition of TSH."
OK, here is a quote strait out of the research:
"The effects of T2s were compared with those elicited by 3,5,3'-triiodo-L-thyronine (T3) (2.5 microg/100 g BW). The serum TSH level was much greater in hypothyroid rats than in euthyroid ones. T3 administration suppressed TSH by 88% compared to control (i.e, the level in hypothyroid rats); it thus reached a value not significantly different from that seen in the euthyroid rats. 3,5-T2 produced a similar effect, suppressing the TSH level by about 75% compared to control; it thus reached values not significantly different from those of the euthyroid and T3-treated rats."(Life Sci 1998;62(26):2369-77)
According to this research, T3 suppressed TSH by 88% at 2.5 mcg/100g BW and T2 suppressed TSH by 75%. To me that is not much difference! Certainly nothing close to the claim of only 1% difference.
There is however another form of T2 called 3,3'-diiodo-L-thyronine or 3,3'-T2. Now 3,3-T2, as apposed to 3,5-T2, has virtually no effect on TSH. However, it also has virtually no metabolic effect at all. Could it be that the company making claims about T2 has confused research looking at 3,3-T2 with that of 3,5-T2?
The claim continues…"At the same time, T2 is just as metabolically potent, and in some instances more potent than T3 — like with increasing hepatic oxygen consumption and uncoupling mitochondria."
When comparing "potency" of T3 and 3,5-T2 you have to take into consideration the several effects of T3. There are at least 3 receptor types for T3, each one seems to have a distinct effect. For example, just because both T3 and 3,5-T2 may increase hepatic oxygen consumption doesn’t mean they will have identical effects when taken as a dietary supplement. For example, in a study comparing T3, 3,5-T2, and 3,3-T2 it was found that low doses of 3,5-T2 (>20 micrograms/100 g BW/day) had no significant influence on body weights, but significantly decreased TSH and T4 serum concentrations. At a high dose of 200 micrograms/100 g per day, T2 suppressed TSH to 43% and T4 to 29% of control levels. T2 will indeed suppress your thyroid output folks.
On the other hand T3 at only 1-15 micrograms/100 g per day, used as a comparison to T2, had significant effects on TSH and T4 levels, and also on body weight. Fifteen micrograms T3/100 g per day decreased TSH to 44%, T4 to 25%, and body weight to 59% of control levels.
In long term experiments (3 months) a low dose (25 mcg/100 g per day) of T2 suppressed TSH to 60% and T4 to 57% of control levels and had no significant effect on body weight. Conversely, 0.1 microgram/100 g per day T3 had significant effects on body and organ weights as well as pellet intake, but with less TSH suppression.
It is incorrect to say that T2 is just as potent for losing body fat as T3. It is even more incorrect to say that T2 will not wreak havoc with your own thyroid output. Here is what the research has to say about T2 compared to T3, "In vivo, T2 has been shown to suppress TSH levels at doses that do not produce significant peripheral manifestations of thyroid hormone activity. Furthermore, T2 has been shown to produce smaller increments in peripheral indices of thyroid status than does T3, when doses resulting in equivalent suppression of circulating TSH are compared."(J Mol Endocrinol. 1997 Oct;19(2):137-47.) What this means is that, at levels of T2 that cause an equal amount of thyroid suppression as a given level of T3, T2 fails to produce as much thyroid effect as T3. So you get more suppression with less activity.
Last claim, "Bottom line with T2, it has every bit as much horsepower as T3, with minimal side effects. And if you follow the guidelines on the T2 label — 50 mcg 1-3 times a day for no longer than six weeks — you should have no problems after you discontinue use."
Reading between the bottom lines…T2 does not have as much horsepower as T3. T2 appears to be a more selective agonist of the thyroid receptors (TRs), perhaps failing to activate all of the subtypes. This gives 3,5-T2 unique properties. Keep in mind that 3,3-T2 has no properties and marketers must be careful to distinguish between research looking at 3,3-T2 and 3,5-T2.
Am I saying 3,5-T2 has no benefit to bodybuilders? No. I’m just saying it isn’t as perfect as some would have you believe. It may very well have some effect on fat loss if taken at high enough doses. Keep in mind however that you will experience some rebound. I have not used T2 myself as of yet so I cannot give first hand experience. Nor will I write T2 off as worthless until I either use it myself or until I have some of my clients use it. All I can say about T2 is buyer beware, and more importantly, buyer be educated!
"Some" references I used:
1: Moreno M, Lombardi A, Lombardi P, Goglia F, Lanni A. Effect of 3,5-diiodo-L-thyronine on thyroid stimulating hormone and growth hormone serum levels in hypothyroid rats. Life Sci. 1998;62(26):2369-77.
2: Ball SG, Sokolov J, Chin WW. 3,5-Diiodo-L-thyronine (T2) has selective thyromimetic effects in vivo and in vitro. J Mol Endocrinol. 1997 Oct;19(2):137-47.
3: Horst C, Harneit A, Seitz HJ, Rokos H. 3,5-Di-iodo-L-thyronine suppresses TSH in rats in vivo and in rat pituitary fragments in vitro. J Endocrinol. 1995 May;145(2):291-7.>>>
http://musclemonthly.com/articles/010701-haycock-supplement-science.htm
http://musclemonthly.com/articles/010701-haycock-supplement-science.html
<<<The Scoop on T2 (3, 5-diiodo-1-thyronine)
Hey Bryan,
What is the scoop on this new T2 fat loss compound (3, 5-diiodo-1-thyronine)? The recommended dose is 50 mcg 1 to 3 times a day. The claims are:
"With T2, thyroid production is effectively increased at both the thyroid receptor site, as well as the mitochondria that are located in certain highly metabolic tissues."
"T2, on the other hand, on a mcg-to-mcg basis, is much less suppressive than T3, something on the order of 1%, meaning you'd have to take 100 times the amount of T2, as compared to T3, to get the same inhibition of TSH. At the same time, T2 is just as metabolically potent, and in some instances more potent than T3 — like with increasing hepatic oxygen consumption and uncoupling mitochondria."
"Bottom line with T2, it has every bit as much horsepower as T3, with minimal side effects. And if you follow the guidelines on the T2 label — 50 mcg 1-3 times a day for no longer than six weeks — you should have no problems after you discontinue use."
The scoop is that Diiodothyronine (T2) is an active iodothyronine very similar to T3. T2 is a metabolite of T3, yet it is metabolically active. I guess the best way to cover this particular question is to deal with the claims being made about T2.
First claim, "With T2, thyroid production is effectively increased at both the thyroid receptor site, as well as the mitochondria that are located in certain highly metabolic tissues."
This is false. Thyroid "production" is effectively decreased due to a reduction in both TSH and T4 levels with supplemental T2.
Second claim, "T2, on the other hand, on a mcg-to-mcg basis, is much less suppressive than T3, something on the order of 1%, meaning you'd have to take 100 times the amount of T2, as compared to T3, to get the same inhibition of TSH."
OK, here is a quote strait out of the research:
"The effects of T2s were compared with those elicited by 3,5,3'-triiodo-L-thyronine (T3) (2.5 microg/100 g BW). The serum TSH level was much greater in hypothyroid rats than in euthyroid ones. T3 administration suppressed TSH by 88% compared to control (i.e, the level in hypothyroid rats); it thus reached a value not significantly different from that seen in the euthyroid rats. 3,5-T2 produced a similar effect, suppressing the TSH level by about 75% compared to control; it thus reached values not significantly different from those of the euthyroid and T3-treated rats."(Life Sci 1998;62(26):2369-77)
According to this research, T3 suppressed TSH by 88% at 2.5 mcg/100g BW and T2 suppressed TSH by 75%. To me that is not much difference! Certainly nothing close to the claim of only 1% difference.
There is however another form of T2 called 3,3'-diiodo-L-thyronine or 3,3'-T2. Now 3,3-T2, as apposed to 3,5-T2, has virtually no effect on TSH. However, it also has virtually no metabolic effect at all. Could it be that the company making claims about T2 has confused research looking at 3,3-T2 with that of 3,5-T2?
The claim continues…"At the same time, T2 is just as metabolically potent, and in some instances more potent than T3 — like with increasing hepatic oxygen consumption and uncoupling mitochondria."
When comparing "potency" of T3 and 3,5-T2 you have to take into consideration the several effects of T3. There are at least 3 receptor types for T3, each one seems to have a distinct effect. For example, just because both T3 and 3,5-T2 may increase hepatic oxygen consumption doesn’t mean they will have identical effects when taken as a dietary supplement. For example, in a study comparing T3, 3,5-T2, and 3,3-T2 it was found that low doses of 3,5-T2 (>20 micrograms/100 g BW/day) had no significant influence on body weights, but significantly decreased TSH and T4 serum concentrations. At a high dose of 200 micrograms/100 g per day, T2 suppressed TSH to 43% and T4 to 29% of control levels. T2 will indeed suppress your thyroid output folks.
On the other hand T3 at only 1-15 micrograms/100 g per day, used as a comparison to T2, had significant effects on TSH and T4 levels, and also on body weight. Fifteen micrograms T3/100 g per day decreased TSH to 44%, T4 to 25%, and body weight to 59% of control levels.
In long term experiments (3 months) a low dose (25 mcg/100 g per day) of T2 suppressed TSH to 60% and T4 to 57% of control levels and had no significant effect on body weight. Conversely, 0.1 microgram/100 g per day T3 had significant effects on body and organ weights as well as pellet intake, but with less TSH suppression.
It is incorrect to say that T2 is just as potent for losing body fat as T3. It is even more incorrect to say that T2 will not wreak havoc with your own thyroid output. Here is what the research has to say about T2 compared to T3, "In vivo, T2 has been shown to suppress TSH levels at doses that do not produce significant peripheral manifestations of thyroid hormone activity. Furthermore, T2 has been shown to produce smaller increments in peripheral indices of thyroid status than does T3, when doses resulting in equivalent suppression of circulating TSH are compared."(J Mol Endocrinol. 1997 Oct;19(2):137-47.) What this means is that, at levels of T2 that cause an equal amount of thyroid suppression as a given level of T3, T2 fails to produce as much thyroid effect as T3. So you get more suppression with less activity.
Last claim, "Bottom line with T2, it has every bit as much horsepower as T3, with minimal side effects. And if you follow the guidelines on the T2 label — 50 mcg 1-3 times a day for no longer than six weeks — you should have no problems after you discontinue use."
Reading between the bottom lines…T2 does not have as much horsepower as T3. T2 appears to be a more selective agonist of the thyroid receptors (TRs), perhaps failing to activate all of the subtypes. This gives 3,5-T2 unique properties. Keep in mind that 3,3-T2 has no properties and marketers must be careful to distinguish between research looking at 3,3-T2 and 3,5-T2.
Am I saying 3,5-T2 has no benefit to bodybuilders? No. I’m just saying it isn’t as perfect as some would have you believe. It may very well have some effect on fat loss if taken at high enough doses. Keep in mind however that you will experience some rebound. I have not used T2 myself as of yet so I cannot give first hand experience. Nor will I write T2 off as worthless until I either use it myself or until I have some of my clients use it. All I can say about T2 is buyer beware, and more importantly, buyer be educated!
"Some" references I used:
1: Moreno M, Lombardi A, Lombardi P, Goglia F, Lanni A. Effect of 3,5-diiodo-L-thyronine on thyroid stimulating hormone and growth hormone serum levels in hypothyroid rats. Life Sci. 1998;62(26):2369-77.
2: Ball SG, Sokolov J, Chin WW. 3,5-Diiodo-L-thyronine (T2) has selective thyromimetic effects in vivo and in vitro. J Mol Endocrinol. 1997 Oct;19(2):137-47.
3: Horst C, Harneit A, Seitz HJ, Rokos H. 3,5-Di-iodo-L-thyronine suppresses TSH in rats in vivo and in rat pituitary fragments in vitro. J Endocrinol. 1995 May;145(2):291-7.>>>
http://musclemonthly.com/articles/010701-haycock-supplement-science.htm
fhg43
New member
T2 Day 8: I'll try and update every 5 days or so. Here is what I am taking today:
AM: T2 (1 tab) ECA (~300mg E/30mg C)
PM: T2 (1 tab) ECA (~300mg E/30mg C)
Definitely leaning out!! I still think this is mostly related to diet and exercise, but I think the T2 has helped to increase my metabolic rate a noticeable bit-read on. Haven't had the indigestion I initially reported so I think I have adjusted to the T2. Still feel that tickle in the throat by the thyroid; it ached the first day, but now it is this "awareness"of something being stimulated in there. I have this "empty" feeling-it's not hunger though; I get this feeling when I use ECA.
I end up taking the T2/ECA before and after my long workouts on weekends and the post workout metabolic burn is huge. I get done and stretch, shower, and refuel; and in a few minutes my face is warm and flushed and my temp does go up a bit-not bad. The old BMR has definitely increased! I have noticed my face and neck are leaner; arms are leaner, I have lost fat around my midsection-I'm starting to see my abs a little. My legs don't have much fat on them so I can't really tell if anything is going on there. I am already 10-12% BF so it is really difficult to take off those last few points. This is where the super clean diet and tons of exercise come into play. I think T2 is adding a little bit in there which is what I hoped for. I am expecting most noticeable results from it in 3-4 weeks after the diet has been in effect for awhile and I have a few weeks of good solid training under my belt. In 1 week I start a 10 week prohormone cycle so I'll add a few pounds (hopefully n=muscle and not fat or water). I had been taking creatine after hard workouts (5g), but I'm thinking thats counter to the T2 so I quit. I'll keep posting reports.
FHG
AM: T2 (1 tab) ECA (~300mg E/30mg C)
PM: T2 (1 tab) ECA (~300mg E/30mg C)
Definitely leaning out!! I still think this is mostly related to diet and exercise, but I think the T2 has helped to increase my metabolic rate a noticeable bit-read on. Haven't had the indigestion I initially reported so I think I have adjusted to the T2. Still feel that tickle in the throat by the thyroid; it ached the first day, but now it is this "awareness"of something being stimulated in there. I have this "empty" feeling-it's not hunger though; I get this feeling when I use ECA.
I end up taking the T2/ECA before and after my long workouts on weekends and the post workout metabolic burn is huge. I get done and stretch, shower, and refuel; and in a few minutes my face is warm and flushed and my temp does go up a bit-not bad. The old BMR has definitely increased! I have noticed my face and neck are leaner; arms are leaner, I have lost fat around my midsection-I'm starting to see my abs a little. My legs don't have much fat on them so I can't really tell if anything is going on there. I am already 10-12% BF so it is really difficult to take off those last few points. This is where the super clean diet and tons of exercise come into play. I think T2 is adding a little bit in there which is what I hoped for. I am expecting most noticeable results from it in 3-4 weeks after the diet has been in effect for awhile and I have a few weeks of good solid training under my belt. In 1 week I start a 10 week prohormone cycle so I'll add a few pounds (hopefully n=muscle and not fat or water). I had been taking creatine after hard workouts (5g), but I'm thinking thats counter to the T2 so I quit. I'll keep posting reports.
FHG
Tha One CrumCake
New member
Props on your results, but it's your strict diet and training that's doing it, not the t2.
fhg43
New member
Tha One Crum Cake-
Thanks for the props dude. I attribute most of my results to diet and training but I do believe theT2/ECA may have helped a little. At the end of my T2 cycle I won't be expounding the wonders of T2 and how "The fat was flying off with it", but I'm sure it contributed something to the overall fat loss.
Supplements are just that-supplemental items to give you an advantage. I have no illusions that these items make all the difference.
FHG
Thanks for the props dude. I attribute most of my results to diet and training but I do believe theT2/ECA may have helped a little. At the end of my T2 cycle I won't be expounding the wonders of T2 and how "The fat was flying off with it", but I'm sure it contributed something to the overall fat loss.
Supplements are just that-supplemental items to give you an advantage. I have no illusions that these items make all the difference.
FHG
MonStar1023
New member
BUMP
Stacking Adipo + T2 and going to see how it goes..
Stacking Adipo + T2 and going to see how it goes..
Similar threads
