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VAR vs Dbol effect on HDL
- Thread starter geoboy
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J
Juice Authority
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geoboy said:
Good point regarding the estogen component. Estrogens provoke elevation of VLDL TG only at supraphysiological doses. In contrast, reductions in LDL cholesterol and increases in HDL cholesterol occur even after low physiological doses of estrogens.
Here's a study that clerly shows how var wreaks havoc on HDL levels.
Oxandrolone and plasma triglyceride reduction: effect on triglyceride-rich and high density lipoproteins.
Hara T, Miller JP, Gotto AM Jr, Patsch JR.
Oxandrolone, an anabolic androgenic steroid, has been shown repeatedly to lower plasma triglycerides in hypertriglyceridemic patients. This study was performed to determine which of seven subfractions of triglyceride-rich lipoproteins are affected by the action of oxandrolone with respect to both their plasma levels and composition. Concurrently, we have determined the levels and composition of HDL subfractions and the plasma levels of the major HDL apoprotein, apoA-I. Oxandrolone was administered to two hypertriglyceridemic subjects, one with type III and one with type V hyperlipoproteinemia until plasma triglycerides were below the target level of 270 mg/dl. Two months and two weeks were required for the type III and type V patients, respectively. In both subjects, the treatment caused a reduction in the plasma levels of all seven subclasses of triglyceride-rich lipoproteins without altering their overall composition. LDL were at least temporarily increased. The reduction of VLDL subfractions caused by oxandrolone was accompanied by a progressive and consistent effect on HDL subfractions in both hypertriglyceridemic subjects; in the type III patient, oxandrolone reduced HDL2 from low pretreatment levels further until they became undetectable. The type V subject had no detectable HDL2 levels prior to treatment. In both subjects, oxandrolone lowered the levels of HDL3. This lowering effect was caused by a preferential reduction of the less dense, major HDL3 subfraction, i.e. HDL3L, causing the denser, smaller HDL3 subfraction, HDL3D, to become the predominant HDL class. The lowering of HDL levels was reflected by a decrease in the plasma levels of the major HDL apoprotein, apoA-I. This first report on the simultaneous reduction of VLDL and the larger, less dense HDL subclasses suggest that oxandrolone lowers plasma triglycerides by a mechanism other than increased lipolysis.
PMID: 7316782 [PubMed - indexed for MEDLINE]
D-bol:
Metabolism. 1984 Nov;33(11):971-5. Related Articles, Links
Severe depression of high-density lipoprotein cholesterol levels in weight lifters and body builders by self-administered exogenous testosterone and anabolic-androgenic steroids.
Webb OL, Laskarzewski PM, Glueck CJ.
The effects of nonphysician prescribed, self-obtained, self-administered exogenous anabolic-androgenic steroids and testosterone on plasma total, high- and low-density lipoprotein cholesterol (HDLC, LDLC), and triglycerides were evaluated in 14 adult white men, 11 body builders and 3 power weight lifters. Lipids and lipoprotein cholesterols were quantified during active physical conditioning, both on (for at least 1 month, mean +/- SD 1.8 months) and off (for at least 4 months, 7.3 +/- 2.7 months) self-administered exogenous androgenic steroids. The subjects took 50 to 100 mg methandrostenolone daily plus weekly injections of testosterone 100 to 200 mg and nandrolone decanoate 100 to 200 mg per week. Mean (SD) HDLC on exogenous androgenic steroids, 29 +/- 8 mg/dL, was severely depressed, and was less than 50% of the consistently elevated mean HDLC when exogenous steroids were not used (61 +/- 14 mg/dL, P less than .01 for paired differences). During anabolic steroid use, HDLC was less than or equal to the age- race- and sex-specific 10th percentile in 11 of the 14 men, whereas while off anabolic steroids, HDLC was greater than or equal to the 90th percentile in 7 of the 13 men, and in the top quartile for 3 of the remaining 6 men. Mean LDLC was higher on androgenic steroids (150 +/- 44) than off (125 +/- 38 mg/dL), P less than .05 for paired differences. The ratio of LDLC/HDLC during exogenous steroid use (6.0 +/- 3.7) was nearly triple the ratio obtained when steroids were not taken (2.2 +/- 1.0), P less than .01 for paired differences.(ABSTRACT TRUNCATED AT 250 WORDS)
PMID: 6493049 [PubMed - indexed for MEDLINE]
The second study on D-bol is not as conclusive as the first one since other anabolic agents were used (test and deca).
Here's another that speaks to the effect testosterone has on HDL levels.
Int J Sports Med. 1985 Jun;6(3):139-44. Related Articles, Links
Serum lipids in power athletes self-administering testosterone and anabolic steroids.
Alen M, Rahkila P, Marniemi J.
The purpose of the present investigation was to study the effects of testosterone and anabolic steroids on serum lipids in power athletes. Altogether 11 national top-level adult athletes completed the study. Five of them volunteered for the study group and the rest for controls. The follow-up consisted of 9 months of a strength training period. During the first 6 months, the subjects in the study group self-administered androgenic steroids on an average of 57 +/- 24.9 mg/day. The most interesting observation was the extremely low high-density lipoprotein (HDL) and HDL2 cholesterol concentrations of the androgen users. After 8 weeks of training, the study group had significantly (P less than 0.05) lower HDL cholesterol concentrations than the control group (0.53 +/- 0.11 and 1.14 +/- 0.19 mmol/l, respectively). This difference remained significant from 8 to 32 weeks of training. No systematic changes were observed in the control group. The HDL2 cholesterol concentration decreased by about 80% (P less than 0.01) and HDL3 cholesterol by about 55% (P less than 0.01) from the onset values in the study group. A substantial decrease in HDL cholesterol to total cholesterol and in HDL2 cholesterol to HDL3 cholesterol ratios were also noticed under the influence of exogenous androgens. The results of this study suggest that the sustained use of testosterone and anabolic steroids have a marked unfavorable effect on the pattern of HDL cholesterol in the serum of male power athletes.
PMID: 4030188 [PubMed - indexed for MEDLINE]
J
Juice Authority
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dr0832 said:
They bounce back to normal a few months after var is discontinued. I would always take niacin, green tea extract, omega 3,6,9's, and flax seed to raise HDL levels. Unfortunately there is no prescription medication you can take to raise HDL levels. There are variety of different dugs a doctor can prescribe for lowering LDL but nothing to raise the good cholesteral.
J
Juice Authority
Guest
geoboy said:
Bro getting HDL levels down to 10 is not a good thing at all. Normal range for a healthy adult is > 40. My lowest was 9 and the doctor told me that was lowest she's seen in 15 years of practicing medicine.
buckwheat1
New member
I might have missed it but will dbol have a less of an effect on lipids the ox because of the estrogen activity?
Also, if low dosage test was adminstered while doing a ox cycle would that help offset the effects?
I assumed it would and was going to run 100mg/wk of test with 50mg/d of ox in my next cycle.
Also, what about policanol (sp?) and garlic.
Also, if low dosage test was adminstered while doing a ox cycle would that help offset the effects?
I assumed it would and was going to run 100mg/wk of test with 50mg/d of ox in my next cycle.
Also, what about policanol (sp?) and garlic.
Nucman
New member
Niaspan is the Rx med to raise HDL. It's basicly no flush, extended release Niacin. 1 to 2 gm is the reccommended dose. Just as with niacin, ya have to work up to these levels over time. At that dose niacin becomes slightly hepatotoxic. I think a little of this and a little of that(niacin, omegas, policosanol, green tea extract, ....) is the answer. That way you wont die from the sides.
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