R-ALA vs ALA: A Blood Glucose Impact Analisis

[luto199]

Fonz

Day 1(In the AM only)

1. Take BG measurement
2. Consume a SPECIFIC food.
(I'll give the exact macro-nutrients)
3. Take the r-ala(100mg)
4. Measure BG at the 1 hr mark and 3hr mark

Shouldn't you take the ala first, then eat?? Also, let us know what you eat, 1 pill might not be enough. I go by 1g carbs needs 3mg r-ala.

 

[Fonz]

while blood glucose will be an interesting measure... the one where the impact will be most significant SHOULD be plasma insulin.. though not sure of the cost or availability of that test..

Err.......Macro getting my insulin levels tested 3X/day would
cost $1000's, plus be a royal pain.
The BG strips are $50/50.

Regarding your point, BG measurements are I believe the
most important factor because they will show if
the ALA is truly "ram-jetting" extra glucose into the muscles.
Remember Insulin levels are NOT affected by ALA,
but rather by the amount of carbs+GI of the particular food ingested.

Fonz

 

[Fonz]

Fonz

Shouldn't you take the ala first, then eat?? Also, let us know what you eat, 1 pill might not be enough. I go by 1g carbs needs 3mg r-ala.

Hence the point of the test.

Establishing the correct dosage-response curve per g of carbs
ingested.

Milk, bread, yoghurt etc.. etc.. I'll post the EXACT macro-nutrient
breakdown.

Fonz

 

[macrophage69alpha]

Remember Insulin levels are NOT affected by ALA,
but rather by the amount of carbs+GI of the particular food ingested.

Fonz

agree and disagree.. GI does impact insulin release, but so does r-ala (at least according to studies).. studies show reduced PLASMA INSULIN.

 

[Fonz]

agree and disagree.. GI does impact insulin release, but so does r-ala (at least according to studies).. studies show reduced PLASMA INSULIN.

Sure. BUT its a reduction in PLASMA INSULIn stemming from the
REDUCTION in blood glucose caused by the ALA.

It is an IN-DIRECT mode of action NOT DIRECT.

ALA has NO EFFECT on insulogenic levels DIRECTLY.

Fonz

 

[macrophage69alpha]

Fonz,

that indirect affect should also be present in pancreatic tissue... thus by increasing Insulin sensitivity there... decreasing insulin release.. and pretty sure that the studies reflect just that..

but perhaps it is a misinterpretation...

 

[Fonz]

Fonz,

that indirect affect should also be present in pancreatic tissue... thus by increasing Insulin sensitivity there... decreasing insulin release.. and pretty sure that the studies reflect just that..

but perhaps it is a misinterpretation...

Ok. Where then......

In the Beta or Alpha cells of the Islet of Langerhans?

I'm curious because r-ala seems to have properties that
the normal ala does not, which would mean that the s-ala
completely destroys some benefits of the r-ala in normal ala.

Fonz

 

[Lumberg]

Fonz, I think this is an awesome idea and is a good trade off between scientific methodology and practicality.

I agree with yarpic however in that you do not know the potency of the racemic ALA you are using--how old it is, what conditions it was stored under, etc. Whereas with the R-ALA all that info is readily available.

I can't think of any way to fix that except 1) talk to the guy from kilosports and see if you can find this out (if you trust him) or 2) use another brand that is more reputable.

Frankly I'm not a big fan of kilosports.

JC

 

[Ulter]

"...which would mean that the s-ala
completely destroys some benefits of the r-ala in normal ala."

By George I think you've got it.

"Recent preclinical date suggest that the natural enantiomer[r(+)-a-lipoic acid is responsible for the metabolic action of a-lipoic acid. The non-natural enantiomer [s(-)-a-lipoic acid] even has opposite effects. It downregulates glucose-transporter or increases hyperinsulineamia."

 

[luto199]

damn its just soo confusing!!! Everyone's got a different opinion. I mean c'mon i wish the guys at Wash U would get their hands on r-ala and start testing the sh!!t out of it, b/c were gonna need some high budget independent studies from some pro's to ever settle this dispute.