My rats tolerate the Osta by following it with a glass of water with some Mio in it. As far as the GW-501516, they were wondering if it should be kinda thick. To them it looks a little bit like a gel and at 1ml / 5.0mg (one dose being the entire 1ml syringe full) that's a lot of gel in their mouths. I have been giving them Unique's stuff.