"The idea of DIM acting like yohimbine in blocking the estrogen receptors in fat cells is new to me, it's possible though, has anyone else heard of this?
The only thing I have heard about it, other than that it causes the release proteing bound test, is that it metabolizes carcinogenic estrogens and fat causing estrogens converting them to a more friendly estrogen"
This idea comes from the idea that DIM increases the conversion of estradiol into 2-hydroxyestrogens, which have a higher binding affinity for SHBG. Theoretically, there may be some displacement of testosterone from the SHBG if this occurs. I have not seen any studies confirming this, though. It is not impossible, I simply have not found the references.
Also, 2-hydroxyestrogens are potentially thermogenic (weakly, though), because they are MAO or COMT inhibitors, so they can increase the levels of norepi and other neurotransmitters.
The only thing I have heard about it, other than that it causes the release proteing bound test, is that it metabolizes carcinogenic estrogens and fat causing estrogens converting them to a more friendly estrogen"
This idea comes from the idea that DIM increases the conversion of estradiol into 2-hydroxyestrogens, which have a higher binding affinity for SHBG. Theoretically, there may be some displacement of testosterone from the SHBG if this occurs. I have not seen any studies confirming this, though. It is not impossible, I simply have not found the references.
Also, 2-hydroxyestrogens are potentially thermogenic (weakly, though), because they are MAO or COMT inhibitors, so they can increase the levels of norepi and other neurotransmitters.