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genezapharmateuticals
domestic-supply
puritysourcelabs
RESEARCHSARMSUGFREAKeudomestic
napsgeargenezapharmateuticals domestic-supplypuritysourcelabsRESEARCHSARMSUGFREAKeudomestic

Glycemic and insulin indexes

magdelana

New member
I thought there may be some people who might be interested in this subject.
:D

RW - Please explain the difference between insulin resistance and insulin sensitivity?

JB - Simply put, insulin resistance is bad. If you're insulin resistant, your cells - especially the muscle cells - don't respond to the anabolic effects of normal levels of insulin, i.e. they resist insulin's effects. If this is the case, the body then releases massive amounts of insulin to promote nutrient storage in the resistant cells. Remember, though, that chronic high levels of insulin in the blood are very bad and can cause type 2 diabetes.

Insulin sensitivity is therefore very good. In this case, your cells - especially the muscle cells - respond very well to small levels of insulin. Therefore, they need very little insulin stimulation to get into an anabolic state. So high insulin sensitivity at the muscle level is very desirable.

One way to remember the difference is as follows. If you're dating someone who responds or reacts to any affection you show them, then he or she is sensitive. So they're a good model for insulin sensitivity. It only takes a little affection to get a big response. On the other hand, if the person you're dating is resistant to your affection, then it takes a lot to get them going. Therefore, they're a good model for insulin resistance. It takes a lot of affection to get even the smallest response.

RW - Does insulin sensitivity vary or change?

JB - Insulin sensitivity is unique to each individual but the cool thing is that it can be manipulated by exercise, diet, and supplementation. And that's what I do with my clients to dramatically change their body composition.

Both aerobic and resistance training greatly increase insulin sensitivity through some different and some similar mechanisms. In addition, supplements like omega 3 fatty acids, fish oils, alpha-lipoic acid, and chromium can increase insulin sensitivity. Finally, moderate carbohydrate diets that are rich in fiber can increase insulin sensitivity.

On the flip side, the low-carb, high-fat diets that have become popular can decrease insulin sensitivity. That's why none of my trainees go on no-carb diets, unless they're dieting down for a show and then they'll do occasional no carb diets every few months for a maximum of 3 weeks at a time.

RW - So what are some practical ways to manipulate insulin sensitivity?

JB - Well, typically I've seen tremendous increases in insulin sensitivity with 3-4 intense weight training sessions per week, lasting 1 hour per session. These sessions should be coupled with at least 3-4 aerobic sessions lasting 30 minutes per week. To really target insulin sensitivity, you would perform these sessions separately.

After exercise, the next step would be to supplement with 600 mg of alpha-lipoic acid and concentrated fish oils containing a total of 6-10 grams of DHA and EPA, which are the most active omega 3 fats in fish oils.

Finally, your diet can make a big difference. I recommend moderate quantities - 40-50% of the diet - of fibrous carbohydrates like oatmeal, fruits, vegetables, and whole grains. I also recommend eating moderate quantities (30-40% of the diet) of high-quality proteins like casein, whey, chicken, beef, fish, dairy and eggs. And finally, I recommend eating low quantities (20% of the diet) of fats from olive oil, flax oil, fish oil, and nut oils.

All of these strategies can be combined to make the muscles more responsive to insulin while simultaneously decreasing the fat's responsiveness to insulin. This means more muscle mass with less fat gain… the eternal quest of the bodybuilder!

RW - How important is the insulin sensitivity to my progress as a "natural" bodybuilder?

JB - I think that insulin sensitivity dictates your muscle-to-fat ratio, especially when trying to gain or lose weight. If you're more insulin sensitive during a weight-gain program, you'll gain more muscle relative to the fat that you gain. For example, with normal insulin sensitivity, you might gain 1 lb of muscle for every 2 lbs of fat for a 1:2 ratio. With increased insulin sensitivity, you might gain 1 lb of muscle for every 1lb of fat or even better, 2 lbs of muscle for every 1 lb of fat.

And if you're dieting, you will lose more fat relative to your muscle loss if your insulin sensitivity is high.

Are these things important to bodybuilders? You bet they are! And especially to natural ones. Drug-assisted bodybuilders have super insulin sensitivity. In addition, the drugs enhance their muscle-to-fat-gain ratios. If you're clean, you need to use every natural means at your disposal to alter these ratios as well.

RW - What's the difference between the well known glycemic index (GI) and this insulin index (II)?

JB - The popular glycemic index is a measure of the speed at which carbohydrates enter the blood after a meal. A high-glycemic index means that blood sugar rises rapidly in response to a meal while a low-glycemic index means that blood sugar rises very slowly. Traditionally, nutritionists thought that the faster the carbs got into the blood, the bigger the insulin response. So in an attempt to manage insulin, they recommended always eating low-glycemic foods.

However, several studies since have shown that some low glycemic index foods have huge insulin responses! So the correlation between glycemic index and insulin response breaks down with some foods. For example, milk products have a very low glycemic index. But they promote insulin responses parallel to the highest glycemic foods. What's the deal? Well, it appears that there are several other factors that determine insulin release besides carb content and the rate of carb absorption.

This is why the insulin index was generated. This index actually measures insulin response to a food. So rather than assuming insulin response is correlated with carb absorption, these researchers decided to go ahead and measure it. And their results were eye opening!

RW - If a natural bodybuilder is planning their nutrient intake around the insulin index, what foods would they eat and what foods would they avoid?

JB - One thing to keep in mind is that there is no such thing as a bad food. Well, almost no such thing. I don't think anyone can make a case for powdered, cream-filled doughnuts, besides the fact that they taste damn good! But I hope you see my point. Since I said earlier that sometimes you want an insulin surge - especially after workouts - and sometimes you don't - especially at night before bedtime - we have to realize that we use the insulin index not to condemn foods but to decide when to eat them.

The point I want to stress is that the insulin index helps us add information to the glycemic index to make better food choices. So using both indices is the way to go. Since milk products have a low GI but a high II, these foods aren't optimal when you want to keep insulin low. Other example foods or meal combinations for this situation are baked beans in sauce, meals with refined sugars and fats, and meals that are protein and carbohydrate rich. Each of these foods/combos have low GI scores but high II scores, none of which are optimal for low insulin times. But remember, some times you want high insulin so don't relegate these foods/combos to a dark corner of your nutritional closet.

Conversely, unprocessed fibrous grains and cereals as well as fruits and veggies are great on both scales. In addition, most low-fat protein sources are also great on both scales.



RW - So what times of the day should you increase insulin levels and what times should you concentrate on decreasing them?

JB - Again, I like to spike insulin 2-3 times per day. Remember, though, that my clients are super insulin sensitive due to the training, diet, and supplementation programs I have them following. So they can handle the insulin surges and can actually grow and get lean at the same time. With this said, natural insulin sensitivity declines at night time so perhaps at night, low insulin choices are best. After training however, the goal should be to send insulin through the roof. A sensible plan is to eat 3 high-insulin meals as your first 3 of the day, and 3 low insulin meals to finish the day.
 
"Remember, though, that chronic high levels of insulin in the blood are very bad and can cause type 2 diabetes. "

It is chronic high levels of blood glucose that is very bad, the chronic insulin response is the result, not the cause. The cause of Type II diabetes in many cases is due to obesity. High levels of circulating fatty acids cause skeletal muscle insulin resistance. The resulting increase in blood glucose causes hepatic and adipose tissue insulin resistance.

"I think that insulin sensitivity dictates your muscle-to-fat ratio, especially when trying to gain or lose weight."

Where has this information been published?

"Drug-assisted bodybuilders have super insulin sensitivity. "

Wrong, many AAS can decrease insulin sensitivity as can GH.

"natural insulin sensitivity declines at night time"

I would believe it would be lowest in the morning when cortisol levels are highest.

W6
 
I agree with Wilson6 on all of his coments, and would like to add that any food that has an ultra high GI score (above that of glucose) should be eyed with suspision as well. These foods more than likely increase blood glucose levels rapidly because they directly cause insulin resistance. So the common belief that the higher the GI, the better it is for you post workout is not always valid. Likewise dairy products appear to be directly insulogenic (they can stimulate the pancreas to produce insulin independant of blood glucose levels).

In spatterson's case, I would describe you as hyperinsulemic rather than insulin sensitive, though you would need a glucose challenge to be sure. Hyperinsulemia is possibly a precursor to insulin resistance. No matter what the cause, you should clearly avoid foods that make you feel that way, or have them with some fats and proteins to reduce the crash.
 
Wison, this was on the T-Mag site. So there are many wrong things in it, is that right? I certainly am glad you and MS are here. Any other things that are wrong that you saw?

About the sleepy thing with spatts, if i eat a meal with rather high fat (higher then is normal for me i mean) it absoulutely makes be sleep. I find it VERY hard to stay awake for probably the next 3 hours after the meal. Is this the same as with spatts or something different? The amount or type of carbs i eat does not bother me, but high fat.....zzzzzzzz.
 
I might be changing my opinion on this one. According to a recent review on post prandial; hypoglycemia. "high
insulin sensitivity, probably the most frequent cause (50-70%), which is not adequately compensated by hypoinsulinemia and thus
cannot be measured by indices of insulin sensitivity such as the homeostatic model assessment. Such situations are frequent in very lean
people, or after massive weight reduction, or in women with moderate lower body overweight. PRH is influenced by patient's
alimentary habits (high carbohydrate-low fat diet, alcohol intake). Thus, diet remains the main treatment, although alpha-glucosidase
inhibitors and some other drugs may be helpful."

They also comment that oral glucose tolerance tests are not a very accurate means of measuring this condition. So it looks like small, frequent, high protein/moderate fat low GI carb meals for you! Hahahahahaha, I'll bet that'll be hard to stick to (NOT).
 
I suspect it wouldn't make a big difference. The glucose will just get in more quickly than normal, but I don't know that total glucose uptake and glycogen synthesis will be affected. But who knows??? (not me!)

Magdalena, heres some research food for thought (apologies for being in a cut and past mode today, I just don't have time to digest and retype stuff into simpler english):

"Paired studies were conducted in 18 healthy volunteers (9 men, 9 women) to investigate whether differences in mood and daytime
sleepiness induced by high-fat-low-carbohydrate (CHO) and low-fat-high-CHO morning meals were associated with specific
hormonal responses. Plasma insulin concentrations were significantly higher after low-fat-high-CHO meals, and cholecystokinin (CCK)
concentrations were significantly higher after high-fat-low-CHO meals. SUBJECTS TENDED TO FEEL MORE SLEEPY AND LESS AWAKE 2-3 H AFTER
THE HIGH-FAT-LOW-CHO MEAL, AND RATINGS OF FATIGUE WERE SIGNIFICANTLY GREATER 3 H AFTER THE HIGH-FAT-LOW-CHO MEAL THAN AFTER THE
LOW-FAT-HIGH-CHO MEALl. The results of the present study are consistent with the hypothesis that there is an association between the
lassitude experienced after a meal and the release of CCK"
 
If so, could her high estrogen levels play a role here?


Possbily, but i should say that my twin brother is affected in the same way. It has always been this way with us. A example lately, i ate italian dinner at a resturant with him and my sisterinlaw and he and i were both almost completely to sleep for the rest of the evening.
 
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