FAT cells hyperplasia

[toufeksian]

UHmm , well im very worried about this , i think im not gaining any weight because i have this in mind all the time , every high calorie day im very worried about this...

when the adipose cells are full of fat , new ones have to be made right ? and then , if u cut , u will only shrink that fat cells , but u will not kill the new ones that were created when the others were full , is this right ??

can anyone give some explanations , or something about this ? should i be worried while bulking about this ??

 

[pintoca]

It's my understanding that the number of fat cells remains constant. What varies is their SIZE (they are filled with water and glycerol)... the only way to reduce the actual number of cells is through surgery (liposuction or such) reason why the plastic surgeons happily anounce that after such a procedure you will not be fat in that particular area again (they removed the cells and your body cannot make more)

The ability of those suckers to grow in size and expand, though, it is AMAZING.

 

[harbinator]

UHmm , well im very worried about this , i think im not gaining any weight because i have this in mind all the time , every high calorie day im very worried about this...

when the adipose cells are full of fat , new ones have to be made right ? and then , if u cut , u will only shrink that fat cells , but u will not kill the new ones that were created when the others were full , is this right ??

can anyone give some explanations , or something about this ? should i be worried while bulking about this ??

Bodybuilders do some insane bulking and are able to cut it right back off, stop letting this affect your progress.

 

[macrophage69alpha]

It's my understanding that the number of fat cells remains constant. What varies is their SIZE (they are filled with water and glycerol)... the only way to reduce the actual number of cells is through surgery (liposuction or such) reason why the plastic surgeons happily anounce that after such a procedure you will not be fat in that particular area again (they removed the cells and your body cannot make more)

The ability of those suckers to grow in size and expand, though, it is AMAZING.

fat cells unfortunately experience both hypertrophy and hyperplasia, luckily they can also experience apoptis (cell death).


as a note- one of the benefits of R+ lipoic is that it stops fat cell maturation (via PPARgamma modulation and MAPK activity)- once a fat cell becomes mature its "sustains" itself (via its own hormonal mechanisms) and is capable of significant hypertropy and, unfortunately, hyperplasia.

 

[toufeksian]

and when they start programing themself to death ? in what circumstances?

 

[toufeksian]

hello?

 

[VictorBR]

fat cells unfortunately experience both hypertrophy and hyperplasia, luckily they can also experience apoptis (cell death).


as a note- one of the benefits of R+ lipoic is that it stops fat cell maturation (via PPARgamma modulation and MAPK activity)- once a fat cell becomes mature its "sustains" itself (via its own hormonal mechanisms) and is capable of significant hypertropy and, unfortunately, hyperplasia.

>>>> Exactly . fat cells will grow ( hypertrophy ) , but sometimes when they are totally full they will create NEW ones - AKA HYPERPLASIA .

So , now instead of 5 million fat cells you have 6 millions . Just an example .

Yeah kinda sucks but you know what ?

Correct me if I am wrong macro , but even if you have 10 TRILLION fat cells in your body you won't LOOK FAT if ALL of them ARE SMALL SIZE CELLS . What makes you fat is the SIZE of your fat cells NOT HOW MANY you have . Am I right ?

One thing I didn't know macro is that fat cells can DIE ?!?!?? REALLY ? So if you diet hard for a long time , you not only SHRINK your fat cells but you also get rid of them ? So instead of 6 million cells you might have 4 million ?? is that it ??

I thought the only way to kill fat cells were liposuction ?


Victor

 

[VictorBR]

It's my understanding that the number of fat cells remains constant. What varies is their SIZE (they are filled with water and glycerol)... the only way to reduce the actual number of cells is through surgery (liposuction or such) reason why the plastic surgeons happily anounce that after such a procedure you will not be fat in that particular area again (they removed the cells and your body cannot make more)

The ability of those suckers to grow in size and expand, though, it is AMAZING.

>>> That is what they say bro , but not true , like macro said , fat cells when full will create new fat cells , aka - hiperplasia .


Victor

 

[kimchee411]

This is probably wishful thinking, but might those small leftover adipose cells actually help with metabolism since they still go through the metabolic processes required to keep them alive, expending energy? And yeah, what triggers apoptosis in fat cells?

 

[macrophage69alpha]

Obes Res. 2005 Jun;13(6):982-90.


Green tea polyphenol epigallocatechin gallate inhibits adipogenesis and induces apoptosis in 3T3-L1 adipocytes.

Lin J, Della-Fera MA, Baile CA.

444 Edgar L. Rhodes Center for Animal and Dairy Science, University of Georgia, Athens, GA 30602-2771, USA.

OBJECTIVE: Green tea catechins have been shown to promote loss of body fat and to inhibit growth of many cancer cell types by inducing apoptosis. The objective of this study was to determine whether epigallocatechin gallate (EGCG), the primary green tea catechin, could act directly on adipocytes to inhibit adipogenesis and induce apoptosis. RESEARCH METHODS AND PROCEDURES: Mouse 3T3-L1 preadipocytes and mature adipocytes were used. To test the effect of EGCG on viability, cells were incubated for 3, 6, 12, or 24 hours with 0, 50, 100, or 200 microM EGCG. Viability was quantitated by MTS assay. To determine the effect of EGCG on apoptosis, adipocytes were incubated for 24 hours with 0 to 200 microM EGCG, then stained with annexin V and propidium iodide and analyzed by laser scanning cytometry. Both preadipocytes and adipocytes were also analyzed for apoptosis by terminal deoxynucleotidyl transferase dUTP nick-end labeling assay. To determine the effect of EGCG on adipogenesis, maturing preadipocytes were incubated during the 6-day induction period with 0 to 200 microM EGCG, then stained with Oil-Red-O and analyzed for lipid content. RESULTS: EGCG had no effect on either viability or apoptosis of preconfluent preadipocytes. EGCG also did not affect viability of mature adipocytes; however, EGCG increased apoptosis in mature adipocytes, as demonstrated by both laser scanning cytometry and terminal deoxynucleotidyl transferase dUTP nick-end labeling assays. Furthermore, EGCG dose-dependently inhibited lipid accumulation in maturing preadipocytes. DISCUSSION: These results demonstrate that EGCG can act directly to inhibit differentiation of preadipocytes and to induce apoptosis of mature adipocytes and, thus, could be an important adjunct in the treatment of obesity.