mendo said:
Tbol increases free test because it binds better then natural test to receptors in muscle tissue...by out-competing with test, more test is freed up. Personally I suspect two things from this: 1) this is temporary, and once your natural test production has been supressed for awhile - your free test level is no longer elevated above baseline. This could partly explain why many of us only see results from Tbol for about 3 weeks or so. 2) Elevated free test from Tbol DOES increase the risk of DHT and Gyno sides...because the test can aromatize even though the Tbol can't. If this is true, then the only reason people aren't getting gyno from Tbol induced high test - is because it doesn't stay high for long enough... Just my 2 cents.
Schumann W.
Institut fur Mikrobiologie und experimentelle Therapie
(ZIMET), Jena.
Disposition and excretion of the anabolic steroid Oral-
Turinabol (1;4-chloro-17 alpha-methyl-androsta-1,4-diene-17
beta-hydroxy-3-one) were investigated in male volunteers.
Following single p.o. and i.v. administration of the tritium-
labelled compound the plasma concentration courses of total
radioactivity (1 and 1-metabolites) and of the unchanged
parent drug as well as the urinary excretion were estimated.
From these data model independent pharmacokinetic parameters
based on statistical moments were calculated. 1 is almost
completely absorbed after p.o. administration of 10 mg per
volunteer. Peak concentrations of total radioactivity and of 1
in plasma were reached about 3 h p.a. Irregularities
observed in the plasma level profile following both p.o. and
i.v. administration of 1 are due to a marked enterohepatic
circulation. Orally given 1 is subject to a first-pass
effect, resulting in a diminished systematic availability.
The AUC-ratio of the unchanged drug and the total
radioactivity of 1 : 13 shows the predominance of metabolites
in plasma. After i.v. administration the disposition of
unchanged 1 was found biphasically with a terminal half-life
of 16 h. 1 and its metabolites are preferentially excreted
via the kidneys. The urinary total radioactivity represented
about 60% of the dose following both administrations. Due to
its affinity to SHBG 1 is able to compete for the protein
binding of testosterone, resulting in an increased plasma
level of non protein-bound testosterone.
FREE TEST plasma concentrations increase because Tbol rapidly binds to Sex Hormone Binding GLOBULIN. Free test is immediately available for anabolism as it is tissue saturated--whereas CIRCULATING testosterone can be metabolized.
There is ZERO chance of GYNO.
Chlorodehydromethyltestosterone
Not inherently, nor metabolically.