krishna said:
Can you explain how this increases free test?? You said it yourself, you're going to be suppressed. Just trying to understand you here. I have been interested in both of these compounds for some time, just have never considered them as a stack. And if it increases free test, won't this increase aromatization and reduction as well? You can't have one without the other.
Schumann W.
Institut fur Mikrobiologie und experimentelle Therapie
(ZIMET), Jena.
Disposition and excretion of the anabolic steroid Oral-
Turinabol (1;4-chloro-17 alpha-methyl-androsta-1,4-diene-17
beta-hydroxy-3-one) were investigated in male volunteers.
Following single p.o. and i.v. administration of the tritium-
labelled compound the plasma concentration courses of total
radioactivity (1 and 1-metabolites) and of the unchanged
parent drug as well as the urinary excretion were estimated.
From these data model independent pharmacokinetic parameters
based on statistical moments were calculated. 1 is almost
completely absorbed after p.o. administration of 10 mg per
volunteer. Peak concentrations of total radioactivity and of 1
in plasma were reached about 3 h p.a. Irregularities
observed in the plasma level profile following both p.o. and
i.v. administration of 1 are due to a marked enterohepatic
circulation. Orally given 1 is subject to a first-pass
effect, resulting in a diminished systematic availability.
The AUC-ratio of the unchanged drug and the total
radioactivity of 1 : 13 shows the predominance of metabolites
in plasma. After i.v. administration the disposition of
unchanged 1 was found biphasically with a terminal half-life
of 16 h. 1 and its metabolites are preferentially excreted
via the kidneys. The urinary total radioactivity represented
about 60% of the dose following both administrations. Due to
its affinity to SHBG 1 is able to compete for the protein
binding of testosterone, resulting in an increased plasma
level of non protein-bound testosterone.
Free testosterone is immediately available for anabolism as it is tissue saturated.