Barnidge-Evidence suggests that anastrozole's enzymatic down-regulating capabilities are far reaching,meaning after discontinuation,the aromitase production remains suppressed for a while.For this reason,I believe that one can get away with running it in 3-4 month intervals with a couple of months off in between,and most likely not experience little to any aromitase rebound.And I agree completely with vageta,it should be a mandatory staple of any endomorphs bulking and cutting cycles,as you do not want aromitase to up-regulate in the first place.Less aromitase=less estrogen=less A2 populations/activity=LESS BODYFAT ACCUMULATION.