You and I can't speculate what, "Trainer of Freaks" Chris Aceto does for his boys...Colemen, Wheeler, Nassar within the IFBB, but I am damn sure that those men arn't limited to 8-10 week runs of any one particular compound like your average beginner would.
Im willing to bet my bottom dollar that national level npc or pro bodybuilder has a grocery list of drugs as broad and deep as the King James bible.
This has nothing to do with the Captain Insano approach to maximizing first cycles. Were not talking brute force pharmacology, but absolute necessity. These boys, before they ever became recognized pros, were writing and composing there own chemical flow charts.
Undoubtedly, those flow charts are nothing like the ones being composed for them by body morphing perverts like ACETO. Colemen, nassar, wheeler, probably arn't the chemical wizzards you would think them to be. They cycled there drugs just like you, me, E2, and joe did.
The only difference between them and us, is GENETICS!!
Now, factor in SUPERIOR GENETICS, Massive doses, Periodized MASSIVE DOSES, GROWTH HORMONE, AND INSULINE. All this timed, planned, and timed and planned again 280 days out of the year.
NOW, your seeing why a professionals level of achievment compared to our own, doesn't give us a point of reference to argue RECEPTOR up DOWN LEFT OR RIGHT regulation.