I suppose it is just wrong to reply to this thread and not predict. So here goes...
My reasoning here is as follows: Lewis loses when he is afraid. This has been demonstrated throughout his career. Now, the Tua fight is totally unrelated to this fight, because there is no comparing Tua to Tyson. Not even in the power department. Tua was and is all hype. That is not true about Tyson. Lewis's dominion over Holyfield is a classic example of two boxer's styles making the fight easy for the bigger guy. Again, the same will not apply in the fight with Tyson. Lastly, Lewis has a suspect chin, which menas that the question can be boiled down to this---would anyone bet against Tyson if he is in the ring with an opponent with a suspect chin? So betting AGAINST Tyson here without long odds is purely foolish.
Now Tyson--
Those of you who are suggesting that he never beat anybody are exposing your ignorance. Tyson was a fucking monster, no doubt about it. And I GUARANTEE you people weren't BETTING AGAINST HIM IN HIS PRIME, WERE YOU? Nope. Didn't think so. In fact, you were probably among the thronggs of people who were touting him as the greatest ever, saying how he would beat Ali and so on. Suffice it to say that Tyson WAS a great BOXER, as well as a natural FIGHTER. Now, he is only a fighter. Which is why his matches are always so entertaining to us. We aren't really even watching a sport when we watch a Tyson match. It is about something entirely different for Tyson now. The only question in a Tyson match is: WILL HE TRAIN PROPERLY? His greatest asset as a boxer back in his prime was NOT his power, it was his ELUSIVENESS. No one could hit him. Watch the fights. I have, over and over. He bobbed and weaved like a badger. Which gave him a way inside. Which resulted in him connecting with his opponents, and this guy only has to connect once to end the whole thing. Cus saw this immediately. He saw the raw power and concluded that all that was necessary was a way INSIDE. If he could accomplish that he could beat anyone. Which he did. Now, if the last ten years are any indicator of the upcoming fight (and how could they not be?) we have to doubt the actual effectiveness of his training. However, Tyson has evolved somewhat as human being, and while he is still theatrical, he has acquired a certain introspective quality that cannot be dismissed.
Finally, I do not think that Tyson has to be at his best to beat Lewis, but I think Lewis has to be at his best to win, because a single error on Lewis' part will get him KO'd. Factor in conditioning, which is WAY in Tyson's favor, and you wind up with the probability that Tyson knocks Lewis out. When?
Your guess is as good as mine, but I say pretty early, if he doesn't foul out. Let me pin it down...
Tyson in four or less, by KO.