The true benefit of HGH?

[Juice Authority]

I posted this another thread but figured it might be bettter as a single topic. What exactly is the true benefit of HGH? Studies have shown that it has little effect on LBM. All I have ever noticed while on it was a leaning out effect, which can be accomplished through diet and supplements for a lot less money. I don't think the gains I made while on it were any more pronounced than they are when I'm on just a cycle. Then again, I haven't tried the Nutropin Depot yet or done HGH with slin.

 

[Juice Authority]

Here's an example of a study with Serostim: (Granted the study was done on AIDS patients)

http://www.medibolics.com/GHMuscle2.htm

"Several studies of HIV(-) subjects indicate that growth hormone does not increase the portion of the lean body mass (LBM) that is known as muscle, even though growth hormone does increase "lean body mass". Note that LBM describes several compartments of tissue that include muscle, connective tissue, bone, organs, and water, too. These studies found that the increase in LBM with growth hormone in HIV(-) subjects consists of tissue other than muscle. Actually the increase in LBM appears to be mostly water, with perhaps a little connective tissue, and some organ tissue, too. (It should be underlined that organ tissue, like muscle tissue, wastes in HIV, and rebuilding of organ tissue by growth hormone could be an important effect that may improve overall health and survival.)"

Serono studied their serostim to combat the side effects Lipodystrophy in HIV population. A re-distribution of fat around the trunk area and upper back. Since then, HIV cocktails have gotten much better in keeping patients healther thus eliminating the waisting syndrome that is caused by AIDS. North Shore University Hospital, Manhassett NY. conducted a study in HIV + people, who were NOT advanced in there disease, a 16 week study of Serostim @ 18iu's p/d. They were looking to see if there were any lean muscle mass gained at 16 weeks. They did, a whole 3 lbs were gained on 18iu's p/d. No androgens at all were used. Just serostim. That is why is so readaly avalable on the street and nothing else is. Serono will never publish there findings because they know the cost of $1700 per kit, per week all for 3 lbs of lean mass will get them pulled of every medicade and ADAP formulary accross the country for AIDS patients.

 

[Juice Authority]

Effect of exogenous growth hormone and exercise on lean mass and muscle function in children with burns.

Suman OE, Thomas SJ, Wilkins JP, Mlcak RP, Herndon DN.

Shriners Hospitals for Children, Galveston TX 77550, USA. [email protected]

We tested the hypothesis that the administration of recombinant human growth hormone (rHGH) and exercise would increase lean body mass (LBM) and muscle strength in burned children to a greater extent than rHGH or exercise separately. Children, ages 7-17 yr, with >40% body surface area burned, were randomized into groups. One group (GHEX, n = 10) participated in a 12-wk in-hospital physical rehabilitation program supplemented with an exercise program and received 0.05 mg. kg(-1). day(-1) of rHGH. A second exercising group (SALEX, n = 13) received saline. A third group (GH, n = 10) received a similar dose of rHGH as GHEX and participated in a 12-wk, home-based physical rehabilitation program without exercise. The fourth group (Saline, n = 11) received saline and participated in a 12-wk, home-based physical rehabilitation program without exercise. The mean (+/-SE) percent change in lean body mass after 12 wk was not significantly different between GHEX (9.0 +/- 2.1%), SALEX (5.4 +/- 1.6%), and GH (5.8 +/- 1.8%) groups (P = 0.33). However, the mean percent change in muscle strength was significantly greater in the GHEX (36.2 +/- 5.4%) and SALEX (42.6 +/- 10.0%) groups than in the GH (-7.4 +/- 4.7%) or Saline (6.7 +/- 4.4%) groups (P = 0.008). In summary, rHGH GHEX, SALEX, and GH alone produced similar improvements in LBM. However, muscle strength was only increased via exercise.

Publication Types:
Clinical Trial
Randomized Controlled Trial

PMID: 12588788 [PubMed - indexed for MEDLINE]

 

[Juice Authority]

This shows GH reduces bodyfat, which was my previous point.

Short-term growth hormone treatment in girls with Turner syndrome decreases fat mass and insulin sensitivity: a randomized, double-blind, placebo-controlled, crossover study.

Gravholt CH, Naeraa RW, Brixen K, Kastrup KW, Mosekilde L, Jorgensen JO, Christiansen JS.

Medical Department M (Endocrinology and Diabetes) and Medical Research Laboratories, Aarhus Kommunehospital, Aarhus University Hospital, Aarhus, Denmark. [email protected]

BACKGROUND: Most girls with Turner syndrome (TS) receive growth hormone (GH) treatment during childhood and adolescence, but controlled data on the effects on body composition and glucose metabolism are lacking. OBJECTIVE: To study the effects of GH treatment on insulin sensitivity, glucose metabolism, bone turnover, and body composition. METHODS: A randomized, placebo-controlled, crossover study was conducted with girls with TS. All girls with TS were treated with GH 0.1 IU/kg/d subcutaneously at bedtime or with placebo for 2 months and studied at the end of each period. Control subjects were studied once without treatment. Twelve girls with TS, aged 9.5 to 14.8 years (median: 12.9 years) and 16 age-matched control subjects (10.3-16.0 years; median: 12.1 years) were studied. Twenty-four-hour sampling of blood was performed; GH, insulin-like growth factor I (IGF-I), IGF binding proteins (IGFBPs), insulin, glucose, and lipolytic and gluconeogenic precursors were assayed, followed by an oral glucose tolerance test. Body composition was evaluated by dual-energy x-ray absorptiometry scanning and body mass index (BMI). Fasting bone markers were measured. RESULTS: Height was reduced in TS as compared with control subjects. In the placebo situation, 24-hour integrated GH as well as IGF-I was significantly reduced in girls with TS compared with control subjects. Controlling for differences in lean body mass (LBM; or fat mass [FM]) and sexual development did not explain the difference in 24-hour integrated GH. Differences in sexual development, BMI, FM, insulin sensitivity, and IGFBP-3 could explain the difference in IGF-I between TS and control subjects. Carbohydrate metabolism in TS was comparable with control subjects. GH treatment induced insulin resistance, with increments in fasting glucose and insulin, as well as 24-hour insulin. Circulating levels of lipid and gluconeogenic substrates were comparable in TS and control subjects and unchanged in response to treatment. Bone markers increased in response to GH. Total FM was increased in girls with TS, accounted for by an increased FM in the arms and trunk, whereas LBM was decreased. Especially LBM in the legs was decreased. Overall, bone mineral content was diminished. Treatment with GH reduced FM in TS, especially in the arms and legs, and likewise increased total LBM, primarily in the trunk. CONCLUSION: This study documented evidence of impaired GH secretion and action, disproportionate body composition, but a normal carbohydrate metabolism in girls with TS. Short-term GH administration was associated with favorable changes in body composition but also with relative impairment of glucose tolerance and insulin sensitivity. We recommend that glucose metabolism be monitored carefully during long-term GH treatment in these patients.

Publication Types:
Clinical Trial
Randomized Controlled Trial

PMID: 12415026 [PubMed - indexed for MEDLINE]

 

[Laser0001]

I am going to give it a try but Im old and looking for the fountain of youth. Im hoping to improve my sleep and change my skin tone. How did you run it and did you notice any improvements worth mentioning.

 

[Juice Authority]

I am going to give it a try but Im old and looking for the fountain of youth. Im hoping to improve my sleep and change my skin tone. How did you run it and did you notice any improvements worth mentioning.

I'm 30 years old and I've run GH from my mid 20's on. Sleep was improved, stamina, skin tone, etc. but I didn't notice a pronounced change in LBM but did notice a decrease in FT. I've run it on cycles and by itself. When I ran it by itself all I noticed was a leaning out effect.

 

[Laser0001]

Exuse me for my ignorance but I thought I read in the Rick Collins interview that is was not a scheduled drug. Does that mean you could by it like other script drugs?

 

[Juice Authority]

Yes and No. You do need to see a Doc to get a script but it would be MUCH more expensive to buy it that way than it is on the black market unless you can get your insurance carrier to pick up the tab. That would hard to do unless you have HIV.

 

[Laser0001]

I have an appointment at 10.00 tomorrow with a Doc and by the look of the clientele that I have seen in his office Im a bit nervous on the cost.

 

[Nelson Montana]

GH: The most overrated drug on the market.

Everything about GH has been exagerated except for the negitive side effects.