Yeah I thought about ditching the laziness so I googled peptides... Very interesting! Further reading showed a connection between cancer growth and Human Growth Hormone.... Man, how I HATE that C-word....
Thought I'd share what I found:
We all know the benefits of Growth Hormone from a bodybuilding standpoint. Basically it does what the name says, it makes you grow. There are many different mechanism as to how it accomplish this[increasing protein synthesis capabilities, increasing the amount of insulin a person can use effectively, and the release of Insulin-like Growth Factor (IGF-1) which increases cell-division and even creates new muscle cells, hailed as the "Rolls-Royce of muscle building hormones"] Problem comes in when an imbalance is created. Anytime insulin to glucose, testosterone to estrogen, HGH to IGF-1, or any other ratio gets out of balance in human physiology, illness seems to happen. It's only natural. When it comes to cancer, a high level of insulin-like growth factor-1 (IGF-1) appears to be the culprit when IGF-1 : HGH ratios are out of whack.
When I continued reading it seemed that this wasn't really the case. Research show that robust levels of HGH just may prevent many cancers. The problem as mentioned above is mainly IGF-1. But why? The problem lies not with IGF-1 as a stand-alone hormone, but in the IGF binding protein-3 (IGFBP-3), better stated: the lack thereof. When THIS ratio of IGF-1 : IGFBP-3 is upset, the shit could hit the fan:
Researchers announced that, in a six-year study of 32,826 nurses, those with the highest levels of IGF-1 had a two-and- a-half times greater risk of colorectal cancer.
------on the flipside-------
High levels of IGF binding protein-3 (IGFBP-3) produced the opposite effect. Taken from the Department of Nutrition at the Harvard School of Public Health
In the case of those with the highest IGF-1 and lowest IGFBP-3, the relative risk of colorectal cancer rose fourfold, after accounting for differences in weight, height, alcohol intake, and other known risk factors. OK so what do we know now? Let's recap. An increase of Human growth hormone leads to an increase of IGF-1. When IGF-1 levels are increased so much that its ratio to one of it's binding proteins: IGF binding protein-3 (IGFBP-3) become too big, cancer risks increase. Almost all (>95%) of serum IGF-1 circulates bound to specific IGF binding proteins (IGFBPs), of which six classes (IGFBPs 1-6) have been identified. BP3 is thought to be the major binding protein.
Now we have to look at the peptide itself, available for purchase for use in bodybuilding. I'ts called - IGF-1 LR3
The goal when injecting the peptide is to skip the part being precursed and released due to the release of Human Growth Hormone, and to be made readily available for use by the body. This is how its done : “Long R3 IGF-1 is signifacantly more potent than IGF-1. The enhanced potency is due to the decreased binding of Long R3 IGF-1 to all known IGF binding proteins. These binding proteins normally inhibit the biological actions of IGF’s.”
So they purposefully made it to be bound less by IGF binding protein-3 (IGFBP-3)? Didn't we just see that when this ratio of IGF-1:IGFBP-3 is disrupted it creates a high-risk cancer environment as the studies above prove?
I might be missing some serious point here on the workings of IGF-1 LR3 and its binding proteins, or it looks seriously dangerous.
Can someone call a peptide-guy?