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Stew, why are you warning about building up resistance to gear,there is no such thing
- Thread starter Horny
- Start date
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Stew Meat
Guest
I conduct university research at Northeast Louisiana University where I am working on a double degree in biology and psychology. I've have posted on this board for almost a year and I've been researching AS for many. I continually comb through journals and research in areas that interest me, particularly physiological aspects of bodybuilding.
-Stew
-Stew
"What a pain killer does is occupy the sodium/potassium pump and prevents the active transport of Na+ from within the axon chambers after the neuron has fired. This slows the influx of K+ and Cl- wich leaves the neuron unable to fire for longer periods of time. If the neuron can't fire, it can't send a message of pain. If it can't send the messsage, the brain doesn't know that there is injury or trama. The stronger the pain killer, the more it prevents the actions of the sodium/potassium pump and the more it prevents the pain sensations."
STEW, what pain killers work through this mechanism? Narcotics work through opioid receptors, which reduce substance P release. There maybe indirect alteration of the Na/K channels, but it is not through direct inhibition of the channels.
"The same is true for anabolic steroids. The further the levels get from your normal baseline, the harder you liver works to metabolise them. Whenever the levels are remaining high for a long time, eventually the liver becomes so efficient that it is destroying/breakign down the AS before the androgen even has a chance to bind to its appropriate receptors and elicit its anabolic response. It does this in an effort to get levels to return to baseline. Thus, higher and higher dossages must be used in order to have the same response that one once had for low dosses."
Hepatic breakdown of hormones most likely increases (I have not seen any research), but I seriously doubt that it is a primary reason for decreases in activity. And in no way would the liver be able to remove hormones from the system at the rate you are suggesting.
Cell signalling and signal transduction processes are still vastly uncharted territories in molecular biology, and are most likely the areas that we will find the answers to why steroids reduce activity over time. More than not, the cells find a way to decrease activity through one or more minor pathway.
STEW, what pain killers work through this mechanism? Narcotics work through opioid receptors, which reduce substance P release. There maybe indirect alteration of the Na/K channels, but it is not through direct inhibition of the channels.
"The same is true for anabolic steroids. The further the levels get from your normal baseline, the harder you liver works to metabolise them. Whenever the levels are remaining high for a long time, eventually the liver becomes so efficient that it is destroying/breakign down the AS before the androgen even has a chance to bind to its appropriate receptors and elicit its anabolic response. It does this in an effort to get levels to return to baseline. Thus, higher and higher dossages must be used in order to have the same response that one once had for low dosses."
Hepatic breakdown of hormones most likely increases (I have not seen any research), but I seriously doubt that it is a primary reason for decreases in activity. And in no way would the liver be able to remove hormones from the system at the rate you are suggesting.
Cell signalling and signal transduction processes are still vastly uncharted territories in molecular biology, and are most likely the areas that we will find the answers to why steroids reduce activity over time. More than not, the cells find a way to decrease activity through one or more minor pathway.
talonracer
New member
Ok but what about staying on a low level of Test all the time-one that is not much above your baseline?? Then periodically doing cycles of anabolics...........what would this do?? I remember reading an article with a famous powerlifter, don't remember who it was. Anyway the guy was in his 50's,still healthy and strong as a bear but has been on consistantly for 30 years. The thing was he would do very small amounts of anabolics then switch drugs...........I think I recall him saying that currently he was on 400mgs of EQ. Now does all this stuff appy to anabolics too?? It would seem if those receptors downgrade what in the hell would a small amount like that do?? It MAY had been Louie Simmons but please don't quote me. See I don't know how staying on low doses of Test would downgrage your receptors. Test is made naturally by our bodies. So if you are,say,just slightly above your baseline (like 200 to 300 mgs a week) that your receptors would be fine. I'm doing this and its NOT for big gains,its to feel young again and to better hold onto gains. My gains come from anabolics not androgens.
I agree I feel stupid when I read some of these posts. Those goofs that think bodybuilders are all big,dumb goons should read these posts!!! Good work guys keep it up.
I agree I feel stupid when I read some of these posts. Those goofs that think bodybuilders are all big,dumb goons should read these posts!!! Good work guys keep it up.
The Iron Game
New member
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