Stew, why are you warning about building up resistance to gear,there is no such thing

[Stew Meat]

Receptors upregulate temporarily but then downregulate proportionally to the time the receptor is exposed to a static stimuli. All receptors build up tolerance to all substances after a period or time (depending on the compound) which, in turn, will require a higher dosage to make the same progress that was exhibited earlier ( at a lower dosage).

the best real world example is resistance to alcohol that is built up over time. For Example, the amount that got you drunk when you first began is not the same after a period of steady drinking.

Receptors are not permanant fixtures. You go through fresh receptors in the same way that one replaces various other organelles. The receptors that you have today are not the ones you will have in a week.



-Stew

 

[Stew Meat]

"Tolerance to a drug may also develop because the drug's pharcodynamic properties lead to a depletion of neurotransmitters critical to the drug's effects.The drug's actions may lead to a depletion of the transmitters either because the transmittersare used faster than they can be replenished or because the actual synthesis of the transmitters is decreased (perhaps because of excessive activy at the autoreceptors). Therefor, with fewer transmitter molecules available, a larger dose must be administerd."


"Drugs and Behaviour", third edition, David M. Grilly, 1999, Harvard Univeristy, Allyn and Bacon LTD. Pages 95-122

Receptors are not neurotransmitters.
And post synaptic responses of neurons have nothing to do with an AR-mediated response.



-Stew



I still have more to go through, I'll post more as I learn it.


Hope this helps!!!

Cheers [/B][/QUOTE]

 

[Stew Meat]

I read somewere that aspirin and greatfruit juice help with slowering tolerance associated with increase production of liver enzymes. Don't know, if it's true...anybody heard it before?

To my knowlege, it has no action on liver enzymes; however, grapefruit is known to contain an particular isoflavone that increases absorbtion of particular medications taken PO.



-Stew

 

[Big Johnson]

GOOD STUFF

 

[Stew Meat]

One study or empirical studies.

They took men, exposed them to exercise, looked at the number of androgen receptors and found that they had upregulated in response to exercise. They also exposed muscle cells to higher levels of testosterone and found that increasing the number of androgens will upregulate androgen receptors.
Baseline testosterone levels also increased for men who were exposed to exercise as well as IGF-1 levels hkowever, in the women in the study, IGF-1 levels increased, but baseline testosterone did not increase when exposed to resistance exercises.


-Stew

 

[2Thick]

They took men, exposed them to exercise, looked at the number of androgen receptors and found that they had upregulated in response to exercise. They also exposed muscle cells to higher levels of testosterone and found that increasing the number of androgens will upregulate androgen receptors.
Baseline testosterone levels also increased for men who were exposed to exercise as well as IGF-1 levels hkowever, in the women in the study, IGF-1 levels increased, but baseline testosterone did not increase when exposed to resistance exercises.


-Stew

Please answer my question. Was it one study or from empirical research.

 

[Stew Meat]

To my knowlege, it has no action on liver enzymes; however, grapefruit is known to contain an particular isoflavone that increases absorbtion of particular medications taken PO.



-Stew

 

[Stew Meat]

Please answer my question. Was it one study or from empirical research.

Emperical research.



-Stew

 

[guards]

Stew Meat:

i am interrested in where you get your information? Can you quote a source?

 

[Stew Meat]

Stew Meat:

i am interrested in where you get your information? Can you quote a source?

You'll have to be more specific.

What would you like me to cite?



-Stew