Actually, as much as I hate to say it, Mikeraz is a little correct here.
Methylation typically = Weaker AR Binding but a highly-extended half-life, which in most cases creates a more biologically active androgen. The most potent are typically C-17aa, however T is NOT the most potent non-c-17AA steroid.
That is why I specified "potency at the receptor" (an injected undecanoate ester, for example, would have a much longer half-life still) -- also don't orals also have positive effects on IGF-1 in the liver...???
That is why I specified "potency at the receptor" (an injected undecanoate ester, for example, would have a much longer half-life still) -- also don't orals also have positive effects on IGF-1 in the liver...???
The half-life of the T ester is not relevant here, only the half-life of biologically active free test, which is measured to be only a few to several minutes. C-17AA's on the other hand have dramatically longer half-lives (hours) as active agents. Plus methylation usually reduces significantly binding to serum proteins as well, another plus. The most potent steroids tend to be those that have very long half-lives because they are very resistant to metabolism, and bind poorly with serum proteins, yet often do not bind the most actively to the AR.
I think the relationship between steroids and IGF-1 is overrated. The link between estrogen and G6PD is probably more significant in terms of non-AR mediated effects. But it is still technicaly a positive.
Change that to "the most POTENT never marketed AAS are typically methylated" and it is a correct statement. But when you used this line of thought in you initial argument against 1-testosterone being a potent steroid, you certainly were incorrect.
Knowing that you haven't a clue about the vast majority of the myriad of steroids that had been synthesized over the years, that is a very ignorant statement to make. And also a very incorrect one.
Yes, but I'm not going to take the time to look up the extensive list of potent non-methylated structures for you. Go to the library, do some research, then we can debate when you know a little bit more of what you are talking about.
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