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napsgear
genezapharmateuticals
domestic-supply
puritysourcelabs
Research Chemical SciencesUGFREAKeudomestic
napsgeargenezapharmateuticals domestic-supplypuritysourcelabsResearch Chemical SciencesUGFREAKeudomestic

PA1AD or Par Deus question on inj. 4ad and 19nordiol

MIKERAZ said:

I find that hard to belive, It must be 17aa ,because there are no compounds that arent 17aa that are very potent

17-alpha alkylation just makes more of the drug make it past the liver, it has nothing to do with potency at the androgen receptor.
 
Par Deus said:
17-alpha alkylation just makes more of the drug make it past the liver, it has nothing to do with potency at the androgen receptor.

Hey Par,

Actually, as much as I hate to say it, Mikeraz is a little correct here.

Methylation typically = Weaker AR Binding but a highly-extended half-life, which in most cases creates a more biologically active androgen. The most potent are typically C-17aa, however T is NOT the most potent non-c-17AA steroid.

- Bill Llewellyn
 
MIKERAZ said:
So why werent these more powerful steroids marketed?

They probably had some wicked side effects and/or health risks. Drug companies produce lots of potent drugs that never get to market. Sometimes the supposed benefits are outweighed by the side effects. Look at a theoretical AIDS vaccine: it could prevent AIDS or it could infect the vaccinated person! Drug companies have probably devised some really, really scary stuff but they could never sell it. What if they created a steroid that caused muscle to visibly grow, but one of the side effects was uncontrollable bleeding of the liver! They could never market such a drug so there would be no need to regulate it. In fact such an experimental drug would only exist in small batches in a research lab somewhere and few would know of its existence-so why do a lot of work to regulate it!? It won't ever be used by anyone. Kinda see the point. Dudes like PA might discover and patent a super anabolic substance, but if they couldn't sell it as a supp or script drug-what good is it other than just as a research tool?

FHG
 
OK a recap, correct me if im wrong

The anabloic control act only contains roids(and esters etc) that were commercially available ever, There are many potent steroids synthesized but not many we made

Just out of curiosity how many where synthesized , and how come they never made a dht commercially available
 
Originally posted by MIKERAZ
OK a recap, correct me if im wrong

The anabloic control act only contains roids(and esters etc) that were commercially available ever, There are many potent steroids synthesized but not many we made


Pretty much, depending on how you define commercially available.

Just out of curiosity how many where synthesized , and how come they never made a dht commercially available

Not sure of the exact count, but hundreds at the very least. DHT was and is still made, but not readily.

- Bill Llewellyn
 
MIKERAZ said:
define commerically? and dht is on the list right ?

A drug like methyltrienolone may not be sold as a prescription, however is available and used commonly as a reference androgen for research purposes. I include a drug like this in my definition.

DHT is on the list.

- Bill Llewellyn
 
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