Lj100?

[Triple J]

LJ100 is patented and the products that advertise having LJ100 basically all contain the same source of LJ100 from the parent company that produces and sells it to them. at least that is my understanding.

 

[Ross]

LJ100 is patented and the products that advertise having LJ100 basically all contain the same source of LJ100 from the parent company that produces and sells it to them. at least that is my understanding.

YES, but some products do NOT contain "LJ100", but some 20:1 or 50:1 garbage extract of Tongkat Ali.

Furthermore, every company that DOES use REAL LJ100, uses it in an INFERIOR DOSAGE.


The maximum anabolic dosage is 300mgs of PURE LJ per day, which is what we use.

 

[Magick69]

well i want it . where to get it guys?
I have seen it come up on diff boards as one of the only otc test boosters thats wont shut you down...

what dose?
how long?
whats the cost?

i see it all over the place online diff price ranges whats the best brand ?

i used tribestan 12 years ago and actually noticed a difference some agression not really that much but enough for a edge back when I was natural.
so I want to combine the two...

bro this is the real deal

http://www.herbal-powers.com/lj10expow.html

read also research etc....

 

[Ross]

bro this is the real deal

http://www.herbal-powers.com/lj10expow.html

read also research etc....

YUP!

You need 200-300mgs a day for the anabolic effect.

I have designed a supplement containing 300mgs per day. (to be discussed later!)

 

[Anthony Roberts]

From bb.com

1. What is it and where does it come from?

Longjack (Eurycoma Longifolia Jack / Tongkat Ali / Malaysian Ginseng / Pasak Bumi) is a bitter tasting herb extracted from the Eurycoma shrub grown in Malaysia and Asia. The Eurycoma Longifolia Jack extract is taken from the roots of the plant.

As a dietary supplement Longjack is available in powder or pill form.

2. What does it do and what scientific studies give evidence to support this?

Longjack has been used traditionally as an aphrodisiac and libido booster. Scientific studies support its use for this purpose and demonstrate that it is effective at boosting sexual function and endurence.1,2,3,4,5,6

Longjack is believed to stimulate the production of endogenous testosterone and to reduce the levels of bound and metabolically inactive testosterone in the body. It is believed to achieve this feat through the Leutinizing Hormone (LH) pathway. Consequently, users of Longjack commonly report an association between Longjack administration and increased feelings of well-being, increased sex drive, improved joint health, greater recovery from exercise of intense but appropriate duration, improved mental focus, and improved immune system function and reductions in body-fat.

As a potent source of antioxidants, Longjack may have immunoprotective and anti-cancer properties.

3. Who needs it and are there any symptoms of deficiency?

No physiological need for Longjack exists and thus no symptoms of deficiency exist.

Longjack administration may be efficacious for persons looking to improve sexual function and quality of life, for athletes looking to improve strength, muscle tone and performance, and the elderly and those with declining endogenous anabolic and androgenic hormone levels.

The ability of Longjack to improve sexual performance and improve sexual endurance will greatly assist persons looking to improve the qualitative qualities of sexual activity.

Athletes looking to improve performance will benefit from Longjacks ability to boost testosterone, protect and boost immune function, enhance muscle tone and strength, as well as its ability to reduce body fat levels.

Longjack supplementation is ideal after a cycle of anabolic or androgenic steroids. Longjack supplementation at this time will offset testosterone down-regulation and encourage testosterone up-regulation. This will help the chemically assisted athlete avoid the hormone "crash" that is typical post anabolic or androgenic steroid administration.

4. How much should be taken? Are there any side effects?

Strictly adhere to label recommendations.

Evidence indicates that side-effects are limited and rare.

REFERENCES

1. Ang HH, Lee KL, Kiyoshi M. Eurycoma longifolia Jack enhances sexual motivation in middle-aged male mice. J Basic Clin Physiol Pharmacol. 2003;14(3):301-8.

2. Ang HH, Lee KL. Effect of Eurycoma longifolia Jack on libido in middle-aged male rats. J Basic Clin Physiol Pharmacol. 2002;13(3):249-54.

3. Ang HH, Ngai TH, Tan TH. Effects of Eurycoma longifolia Jack on sexual qualities in middle aged male rats. Phytomedicine. 2003;10(6-7):590-3.

4. Ang HH, Lee KL. Effect of Eurycoma longifolia Jack on orientation activities in middle-aged male rats. Fundam Clin Pharmacol. 2002 Dec;16(6):479-83.

5. Ang HH, Cheang HS. Effects of Eurycoma longifolia jack on laevator ani muscle in both uncastrated and testosterone-stimulated castrated intact male rats. Arch Pharm Res. 2001 Oct;24(5):437-40.

6. Ang HH, Cheang HS, Yusof AP. Effects of Eurycoma longifolia Jack (Tongkat Ali) on the initiation of sexual performance of inexperienced castrated male rats. Exp Anim. 2000 Jan;49(1):35-8.

I find it interesting that (check out the highlighted portion of the post above) "It is believed" that this stuff increases testosterone. It is believed that it does this, although not one study on medline has said that it does...none suggest it is anything more than an aphrodesiac.

I read through 2 pages of abstracts (29 studies) and not one with "Eurycoma Longifolia Jack" says that it increases testosterone. Not one.

It does seem to have an anabolic/androgenic effect (you would have to take a full bottle several times a day, and you would likely need to inject it), but I can't find out why it would be said to increase testosterone. That seems to be speculation.

 

[OMEGA]

I agree Anthony

its just an aid possibly for Libido much like Trib.

There is nothing wrong with these products to possibly "prime" the male environment

but to RAISE test?

 

[Ross]

Preliminary Biological Activity:
Preliminary biological activity:
i) testosterone level
- incubation of E. longifolia aqueous extract in rat testicular homogenate
- steroid hormones (testosterone) analysis – capillary gas chromatography
Steroid Hormone Level LJ100 ®Extract Control
Testosterone 3.91 ±0.73 1.53 ±0.19
Progesterone 23.62 ±1.25 trace
17-OH Progesterone 5.28 ±0.46 0.95 ±0.23

LJ100® helps to activate enzymes activities that convert pregnenolone and 17-OH pregnenolone into progesterone and 17-OH progesterone.


Control
Prenenolone
LJ100®

An a
2.52
1.62
6.64

*
+0.12
+0.28
+0.44

An b &
2.64
1.99
0.38

Andien b
+0.09
+0.44
+0.11

An a, an b, and andien b are steroid metabolites that belongs to 16-androstenes steroid family, also known as pheromones are axillary secretion responsible in the synthesis of odour. An a plays an important role in communication, psychological and sexual behavior both in human and animals. This study shows that LJ100® is not only capable in increasing the testosterone production but at the same time it also influences the synthesis of pheromones.


Pregnenolone metabolite analysis in mice
ug steroid/10 mg protein

Steroid Extract Blank Control LJ100® (2) LJ100 (3)
5a-androstenone * * * *
androstenedione * * * 0.08
andien b & an-b 4.05 2.68 0.88 1.42
an-a 22.57 32.7 109.99 207.26
5-androstediol * * * *
5a-DHT * * * *
4-androstenedione * * * 0.07
testosterone 0.98 1.68 2.43 2.87
5a-androstane-diol * * * *
7-OH preg 2.43 5.15 1.41 1.31
progesterone 3.36 6.39 12.30 13.20

Note that there is no elevation of the dihydrotestosterone.


ug steroid/10 mg protein

Steroid % increase Blank Control LJ100® (2) LJ100® (3)
testosterone 180% 0.98 1.68 2.43 2.87
progesterone 190% 3.36 6.39 12.30 13.20

Steroid metabolite analysis (in human testes)

ug steroid/10 mg protein

Steroid Derivatives Control Pregnenolone LJ100®
5a-Androstane-3a,17 b-diol 5.12± 1.06 7.89 ± 0.82 5.75 ±0.32
5-Androstenediol 8.19 ±0.31 11.39 ±0.75 7.42 ±0.19
5a-Dihydrotestosterone 21.24 ±2.13 25.44 ±2.25 20.53 ±0.61
16-Dehydropregnenolone 3.72 ±2.04 3.94 ±0.91 4.86 ±0.94
testosterone 2.48 ±0.96 2.91 ±0.76 12.91 ±1.0
17-Hydroxypregnenolone 0.11 ±0.02 0.76 ±0.04 0.09 ±0.00
4-Androstenedione 18.33 ±4.21 21.58 ±0.94 24.51 ±1.83

Treatment effect towards testosterone concentration in rat Leydig Cells

Treatment Testosterone Concentration (pg/ml) % increase
Control 8.92 ±1.68
hCG 13.14 ±2.61 47.27
lac 13.03 ±3.10 46.11
LJ100® 19.38 ±2.70 119.77

hCG- Human Chrorionic Gonadotropin

lac-lactate

Based on the steroid biosynthesis pathways, CYP17 was selected for this study;

CYP17 that converts pregnelolone ® 17-OH pregnenolone ® DHEA or Progesterone ® 17-OH progesterone ® Androstenedione

Relative values for CYP17 gene following incubation with LJ100®

Treatment
Relative Values

hcg
1.157 ± 282.0

LJ100®
3.807 ± 0.590


CYP17 (17 a-hyroxylase/17,20 lyase) involves in the early stage of steroid biosynthesis. Result from this study showed that LJ100 ®significantly increased the expression of CYP17 gene compred to the positive control (hCG). The observed effect towards CYP17 gene expression might suggests that more of this enzyme is being produced, which will enhanced the matabolism of pregnenolone and 17-OH pregnenolone to yield more dehyroepiandrosterone (DHEA) as well as the metabolism of progesterone and 17-OH progesterone to 4-androstenedione. This process is important in testosterone biosynthesis as DHEA and 4-androstenedione will be directly converted to testosterone.




--------------------------------------------------------------------------------

Anabolic Study of LJ100®
Sareena Hanim Hamzah & Ashril Yusof

Department of Exercise Physiology, Sports Centre, University of Malaya, Kuala Lumpur

Testosterone is renown biochemically for its anabolic nature and net effect of increasing metabolic rate and enhancing the process of biosynthesis. In this study, seven male subjects aged between 26-32 years took 100mg of LJ100 for a period of 8 weeks. Simultaneously, subjects performed an intensive strength training program with initial load of 60% RM, which was carried out on alternate days. Measurement of skin fold thickness, arm circumference, one repetition maximum (1RM) strength on the upper limb and the electormyographic activity of biceps were recorded before and after the period of consumption of LJ100®.

A double blind study on 7 controls was conducted (100 mg lactose) simultaneously. Fat free mass increased from 52.3 (7.1) to 54.4 (7.4) kg (p<0.05). The percentage of fat decreased significantly from 31.3 (5.5) to 28.4 (6.4) % (p<0.05). The arm circumferences of the participants were observed to increase from 30.9 (1.9) to 32.7 (2.0) cm (p < 0.05). The 1RM muscle strength test showed an increment from 73.7 (16.6) to 78.7 (17.0) kg (p < 0.05). The mean frequency of sEMG on bicep muscle contraction of the subjects showed a more significant improvement in strength (p<0.05) compared with the controls (p>0.05). This shows that when Eurycoma administered together with exercise gave a greater gain in strength. The results suggest that LJ100® standardized extract of Eurycoma longifolia Jack can have an anabolic effect on muscle cells.

Results:

Placebo (100mg/day) LJ100® Eurycoma Extract (100mg/day)
Parameters Pre (mean + SD) Post (mean ± SD)
Pre (mean + SD) Post (mean ± SD)
FFM (kg) 52.44 + 3.77 52.77 + 7.18 52.26 + 7.18 54.39 + 7.43*
Fat Mass (%) 22.83 + 2.43 21.33 + 2.35* 31.30 + 5.48 28.44 + 6.43*
1 RM 77.29 + 8.90 79.43 + 8.83 73.71 + 8.90 78.71 + 17.00*
Arm Cir (cm) 29.8 + 3.70 30.7 + 3.86 30.87 + 1.88 32.67 + 1.96*
sEMG (mV) 127.95 + 30.90 98.8 + 50.1 121.77 + 40.0 90.47 + 64.6*

*Results of mean ± SD for pre and post experiment showed significant difference (p<0.05)

The mean frequency of sEMG on bicep muscle contraction f the subjects showed a more significant improvement in strength (p<0.05) compared with the controls (p>0.05). The results suggest that LJ100® has an anabolic effect on muscle cells.


--------------------------------------------------------------------------------

LJ100® effects on Total Testosterone, DHEA, & SHBG

University of Malaysia, Dr. Ismail Tambe

Conclusions:

Total testosterone levels do not show LJ100® does not disrupt steroidogensis. This suggests the feedback system is activated to ensure the testosterone levels are within the individuals needs range. (This confirms that LJ100® is not a steroid that will result in the unhealthy side effects of steroidal use.)

Analysis of DHEA showed gradual increase in the level from 26% after 1 week to 47% after 3 weeks (using 100mg dose). This suggests that the extract may influence the DHEA production, which would in turn subsequently be aromatized to testosterone.

SHBG (Sex Hormone Binding Globulan) analysis showed that levels were reduced in 36% of the cases after one week. The reduction went up to 66% after 3 weeks. This suggests that the extract could have an effect on the production of SHBG. (Reduction in SHBG indicates less protein to bind with androgen and therefore more free androgen for use by organs. A reduction will also reduce fat production.)


--------------------------------------------------------------------------------

Saliva Testosterone Test of 9 Individuals 26-52 years of Age

¢Dosage 2x2(50mg/capsules) morning & evening for 10 days

¢Normal range for athlete 800 = 150ng/dl of blood



Volunteer age pre treatment after treatment %

ng/dl blood ng/dl blood Increase

1 26 860 = 30 1,650 = 50 91.86%

2 28 580 = 30 985 = 35 69.83%

3 35 875 = 40 1, 576 = 60 80.11%

4 24 950 = 45 2,210 = 55 132.63%

5 29 755 = 30 1,345 = 35 78.15%



6 48 650 = 20 875 = 30 34.62%

7 52 450 = 25 765 = 35 70.00%

8 50 585 = 25 875 = 35 49.57%

9 42 350 = 30 480 = 35 37.14%



Data – preliminary data - more work to be carried out

Volunteers 1-5 are athletes - data are an average of 3 different studies at different times

Volunteers 6-9 do not exercise on a regular basis




--------------------------------------------------------------------------------

Effects of E. longifolia on animal testosterone


Animal
Increase %

Mice
479%

Rat
380%

Rabbit
320%

*Human testicular homogenate ( in vitro)


440%


J.M Saad et al 1995






--------------------------------------------------------------------------------



Effect of LJ100® E.longifolia extract on the levels of cAMP and cGMP of rabbit corpus cavernosa.

In this study, the mechanism of action of LJ100® Eurycoma longifolia extract on penile erection was assessed by determining the in vitro formation of cGMP and cAMP in rabbit corpus carvenosum. The effect of E. longifolia was then compared with the effectiveness of sildenafil citrate (viagra) in triggering penile erection. Corpus cavernosum tissues were treated with LJ100® E.longifolia extract and sildenafil citrate at different concentrations and incubation time. This was done by incubating the rabbit tissues in Dulbelco’s Minimum Essential Medium (MEM) containing various concentration of extract (0, 1.25, 1.875, 2.5, 3.125 and 3.75 µg/ml) and then measuring the cGMP and cAMP level using an enzyme-linked immunoassay (EIA) kit. Prior to this, the optimum concentration of sodium nitroprusside (SNP) as a stimulus for nitric oxide formation and guanylate cyclase activated, were determined.

Significant findings


1. LJ100® E.longifolia extract increased the level of cGMP in rabbit corpus cavernosum to almost 4-fold.



In the presence of SNP (10 µm) LJ100® E. longifolia extract increased cGMP in rabbit corpus cavernosum with increasing concentrations (1.25 – 3.125 µg/ml). The effective concentration of LJ100® E.longifolia extract is 3.125 µg/ml at 30 minutes incubation. The increase was greatest (5.298pM/mg tissue) compared to control (1.2pM/mg tissue), representing a 4-fold increase. For comparison, a similar study was also carried out using sildenafil citrate, an anti-impotency pill known to act via elevation of cGMP. Sildenafil citrate increases cGMP in rabbit corpus cavernosum with increasing concentrations (10-7-10-4M) in response to SNP (10µM). The effective concentration of sildenafil citrate is 10-4M which increases cGMP up 4.832pM/mg tissue compared to control (0.8pM/mg tissue). The erectogenic effect of sildenafil citrate is mediated by specific enhancement of cGMP accumulation in the corpus cavernosum, consistent with the known activity of sildenafil as a potent and selective inhibitor of cGMP-phosphodiesterase 5 (cGMP-PDE5). The result from preliminary study shows that the mechanism of action of LJ100® E.longifolia extract is similar to sildenafil citrate.



2. LJ100® E.longifolia extract enhances the level of cAMP in rabbit corpus cavernosum; a phenomenon not observed with Viagra.



Effect of sildenafil citrate with concenration 10-4M, 10-5M, 10-6M and 10-7M on cAMP levels also was studied in this research. From the results, LJ100® E.longifolia extract was found to increase cAMP levels in corpus cavernosum and there were no significant increases of cAMP levels in the corpus cavernosum tissue treated with Viagra.



Results of this study validate the physiological observations of the aphrodisiac properties of E.longifolia whereby LJ100® E.longifolia extract is found to increase and enhance the levels of cGMP and cAMP on a time and concentration dependent manner in the rabbit corpus cavernosa tissue, even in the absence of sexual stimuli. The increase in both second messengers indicates smooth muscle relaxation and this can be extrapolated to a penile erection in a in vivo.

 

[Nelson Montana]

You can get it at beyond-a-century for the best price.

I tried it -- the highest potency. It did nothing.

Actually, I felt a little libido DROP. That could have been coinsidence though -- or maybe the increase in progesterone.

Go with avenacosides A&B. It's the only substance proven to raise free testosteone.

 

[Anthony Roberts]

Wow.

You found several studies, none of which have been published in reputable peer reviewed medical journals. Those are called "ads" not studies. What happens is that the company who produces the product pays for a study to be done by an obscure university somewhere in the world where it's not going to be torn apart by the legitimate medical/scientific community, and the results are bought and paid for.

Care to guess what that means? What you are posting is not a valid or legitimate medical study. It's total B.S. It was never even published....it's an advertising toy for the company who makes the product.

Note that it increases test (ha ha) yet doesn't raise DHT. Ummm....yeah...

Lets pretend that the "study" above was even valid (and it's not)...the product is still far inferior to Dermacrine and MyoGenX, based on the numbers we have for those products. Why bother with a second rate test booster?

Here's a good study showing that only about 10% of ths stuff is bioavailable (poor bioavailability):

Bioavailability and pharmacokinetic studies of eurycomanone from Eurycoma longifolia.

Low BS,
Ng BH,
Choy WP,
Yuen KH,
Chan KL.
School of Pharmaceutical Sciences, University Sains Malaysia, Penang, Malaysia.
A validated HPLC analysis of eurycomanone (1), a bioactive quassinoid, in rat plasma following oral and intravenous administration of Eurycoma longifolia Jack extract was developed for pharmacokinetic and bioavailability studies. Relatively high plasma eurycomanone concentrations were detected after an intravenous injection of 10 mg/kg extract F2 containing 1.96 mg/kg of the quassinoid. However, it declined rapidly to zero after 8 h. Its mean elimination rate constant (k(e)), biological half-life (t(1/2)), volume of distribution (V(d)) and clearance (CL) were 0.88 +/- 0.19 h (-1), 1.00 +/- 0.26 h, 0.68 +/- 0.30 L/kg and 0.39 +/- 0.08 L/h/kg, respectively. Following oral administration of eurycomanone, its Cmax and Tmax values were detected as 0.33 +/- 0.03 microg/mL and 4.40 +/- 0.98 h, respectively. The plasma concentration of the quassinoid after oral administration was much lower than after intravenous application in spite of the oral dose being 5 times higher. The results indicate that eurycomanone is poorly bioavailable when given orally. A comparison of the AUC (0-->infinity) obtained orally to that obtained after an intravenous administration (normalized for dose differences) revealed that the absolute bioavailability of the compound was low with 10.5 %. Furthermore, the compound appeared to be well distributed in the extravascular fluids because of its relatively high V(d) value. The poor oral bioavailability was not attributed to instability problems because eurycomanone has been shown to be stable under different pH conditions. Thus, its poor oral bioavailability may be due to poor membrane permeability in view of its low P value and/or high first-pass metabolism.
PMID: 16206032 [PubMed - indexed for MEDLINE]

 

[Anthony Roberts]

Analysis of DHEA showed gradual increase in the level from 26% after 1 week to 47% after 3 weeks (using 100mg dose). This suggests that the extract may influence the DHEA production, which would in turn subsequently be aromatized to testosterone.

Aromatized to testosterone, huh?