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Why Arimidex should not be combined with Nolvadex?

big_boy_1

big_boy_1

New member
In the Arimidex paperwork it clearly states that it shouldnt be used along with tamoxifen (nolvadex).
Why?
It also applies to males?
 
big_boy_1 said:
In the Arimidex paperwork it clearly states that it shouldnt be used along with tamoxifen (nolvadex).
Why?
It also applies to males?
Click to expand...

usually if you don't have gyno, it's overkill
 
marshallmadman said:
A lot of the current PCT regimens call for .5mg/day of Arimidex combined with the typical course of Nolvadex.
Click to expand...

Adex should be taken during your cycle, not for PCT, it serves no purpose for PCT as it will not help you recover.
 
I have taken it a couple of times for PCT purposes (A-dex), and I must say that this go-round has been much better without it. I'm only using 40mg/Nolva per day, and couldn't be happier. No Clomid this time either.:)
 
I used the Nolva/Clomid/A-Dex PCT this last cycle and recovered in unbelievable fashion.

I did however get acne way worse than my prior Clomid only PCTs. I will run this PCT everytime from now on, and Throw in HCG if I run a cycle longer than 10 weeks.
 
bigrand said:
Adex stops aromitase.
Nolva stims estro receptors, body needs more test to counter balance, ups production.
Click to expand...
yea bro arimidex increases your test levels in short-term but once you discontinue the usage of arimidex your testlevels will drop, because arimidex reduces your already low SHBG

also it leads to an accelerated development of atherosclerotic plaques

so i would stick with the serms
 
Problem with adex is post cycle, your not producing test, and all adex does is stop conversion of test to estrogen via aromitase. SERMS actually stimulates production of LH which tells leydig cells in balls to produce test.
 
So does Arimidex. The feedback restraint of LH and FSH secretion by testosterone requires aromatization.


Aromatase inhibition in the human male reveals a hypothalamic site of estrogen feedback.

Hayes FJ, Seminara SB, Decruz S, Boepple PA, Crowley WF Jr.

Department of Medicine and National Center for Infertility Research, Massachusetts General Hospital, Boston 02114, USA. [email protected]

The preponderance of evidence states that, in adult men, estradiol (E2) inhibits LH secretion by decreasing pulse amplitude and responsiveness to GnRH consistent with a pituitary site of action. However, this conclusion is based on studies that employed pharmacologic doses of sex steroids, used nonselective aromatase inhibitors, and/or were performed in normal (NL) men, a model in which endogenous counterregulatory adaptations to physiologic perturbations confound interpretation of the results. In addition, studies in which estrogen antagonists were administered to NL men demonstrated an increase in LH pulse frequency, suggesting a potential additional hypothalamic site of E2 feedback. To reconcile these conflicting data, we used a selective aromatase inhibitor, anastrozole, to examine the impact of E2 suppression on the hypothalamic-pituitary axis in the male. Parallel studies of NL men and men with idiopathic hypogonadotropic hypogonadism (IHH), whose pituitary-gonadal axis had been normalized with long-term GnRH therapy, were performed to permit precise localization of the site of E2 feedback. In this so-called tandem model, a hypothalamic site of action of sex steroids can thus be inferred whenever there is a difference in the gonadotropin responses of NL and IHH men to alterations in their sex steroid milieu. A selective GnRH antagonist was also used to provide a semiquantitative estimate of endogenous GnRH secretion before and after E2 suppression. Fourteen NL men and seven IHH men were studied. In Exp 1, nine NL and seven IHH men received anastrozole (10 mg/day po x 7 days). Blood samples were drawn daily between 0800 and 1000 h in the NL men and immediately before a GnRH bolus dose in the IHH men. In Exp 2, blood was drawn (every 10 min x 12 h) from nine NL men at baseline and on day 7 of anastrozole. In a subset of five NL men, 5 microg/kg of the Nal-Glu GnRH antagonist was administered on completion of frequent blood sampling, then sampling continued every 20 min for a further 8 h. Anastrozole suppressed E2 equivalently in the NL (136 +/- 10 to 52 +/-2 pmol/L, P < 0.005) and IHH men (118 +/- 23 to 60 +/- 5 pmol/L, P < 0.005). Testosterone levels rose significantly (P < 0.005), with a mean increase of 53 +/- 6% in NL vs. 56 +/- 7% in IHH men. Despite these similar changes in sex steroids, the increase in gonadotropins was greater in NL than in IHH men (100 +/- 9 vs. 58 +/- 6% for LH, P = 0.07; and 85 +/- 6 vs. 41 +/- 4% for FSH, P < 0.002). Frequent sampling studies in the NL men demonstrated that this rise in mean LH levels, after aromatase blockade, reflected an increase in both LH pulse frequency (10.2 +/- 0.9 to 14.0 +/- 1.0 pulses/24 h, P < 0.05) and pulse amplitude (5.7 +/- 0.7 to 8.4 +/- 0.7 IU/L, P < 0.001). Percent LH inhibition after acute GnRH receptor blockade was similar at baseline and after E2 suppression (69.2 +/- 2.4 vs. 70 +/- 1.9%), suggesting that there was no change in the quantity of endogenous GnRH secreted. From these data, we conclude that in the human male, estrogen has dual sites of negative feedback, acting at the hypothalamus to decrease GnRH pulse frequency and at the pituitary to decrease responsiveness to GnRH.


And just to clarify AGAIN, clomid is a SERM, and clomid should be used for PCT and if you can't then use HCG.
 
You do need to start with a (selective estrogen receptor modulator) SERM as Ult says though. Post cycle, the boby is void of sex hormone (suppressed test levels and no test = no estro). They work together, SERMS by directly stimulating LH when there is severe hypogonadalism and Adex to speed the process by the mechanism described in the piece Ult generously produced for us here today!
8-)
 
I have read where a physician does not recommend arimidex for PCT, since it is so powerful, it can make estrogen too low, messing up cholesterol profiles. Nolva is supposed to help them, on the other hand - what he recommended.

He did recommend Adex during cycle though when using heavy aromatizing AAS...
 
In my opinion, small dosed Nolvadex SHOULD be used in conjunction with Arimidex.

Arimidex KILLS HDL levels.....Nolva will help keep them in a healthy range. It's YOUR heart!
 
Prince77 said:
Wouldn't the smarter thing to do be to use Aromasin instead of Arimadex anyway? Doesn't Aromasin spare your HDL?
Click to expand...

Supposedly......I'd loveto hear some users' feedback. I use the stuff but haven't had the blood work to prove or disprove this.

Anyone?
 
Ulter said:
I use Nolva with Arimidex on a occasion. Sometimes when I get over 1000mg/wk of test and 500mg/deca I'll get slight gyno syptoms (a little knot under my nipple) and I'll use 20mg/day of nolva to make it go away. Nolva works better in the chest tissue for gyno.
Click to expand...
hey ulter when you getg gyno symptoms can you feel your lumps? i'm on a high dose test and never had problems with gyno up to 2 grams of test, but i'm curious how it would be if i got gyno, just sore nipples or lumps? or do i have to cut down so that i can see the lumps? or should i be able to feel it by pressing a little bit on the area?
 
Whacked said:
Supposedly......I'd loveto hear some users' feedback. I use the stuff but haven't had the blood work to prove or disprove this.

Anyone?
Click to expand...


Arent there some particularly nasty sides to aromasin however thouhg?
 
The only negative on aromasin is it supposedly lowers igf1? Not sure how noticeable it would be though.
 
So lets say currently one wanted to switch from 1mg or so of arimidex ED, to aromasin, what dose would you suggest? 1mg of liquidex ED = how much aromasin.
 
thate said:
The only negative on aromasin is it supposedly lowers igf1? Not sure how noticeable it would be though.
Click to expand...

Isn't that detremental to loosing bf in hormone related areas? Also, Ulter see my Thermorexin thread I made in the supplement forum.
 
i dont wanna bust anyones balls but is there any reason why you cant take arimidex and nolva together ?
what im asking is why would the insert say not to take them together ?
 
bigrand said:
No there is no reason, they are actually better together, they have differrent modes of stimulating test production.
Click to expand...

More specifically, they reduce estrogen through completely different pathways, thus aiding test production.

After reading this thread, I added .5mg/day of Arimidex back into my PCT regimen. In addition, I reduced my Nolvadex dosage from 40mg to 20mg.
 
Whacked said:
In my opinion, small dosed Nolvadex SHOULD be used in conjunction with Arimidex.

Arimidex KILLS HDL levels.....Nolva will help keep them in a healthy range. It's YOUR heart!
Click to expand...

I Agree
 
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