mk677

[Jimmyinkedup]

Anyone with first hand experience?
Honestly I have always considered oral GH secretagogues total garbage but this is an oral GHRP that seems to show some promise. It seems like you could stack it with a cjc w/dac and minimize being a pincushion normal peptide cycles require and get a nice gh/igf boost that might actually make a difference.

 

[romanpiperva]

Honestly, Google "mk-677 synergistic" or something like that, but I am guessing that you wouldn't notice much difference w cjc 1295 or 1293. 1295 would cause a bleed that I don't like the idea of.
So that would leave 1293 (no dac) and then ur back to pinning.

Ever think of lgd or ostarine to stack? I haven't run lgd but love the ostarine and personally believe it has synergy with peptides, due to results, so hope that helps in some small way.

 

[Pepe Le-r3]

I would run Mk677 by itself, or just add a helper supplement. An example would be Huperzine A as an acetylcholinesterase inhibitor, gh supporting aminos(arginine, ornithine, serine, glycine), or a dopamine agonist(Sam-e, or L-dopa). I am going to run my Blackstone Labs Mk Ultra with NOW Pro-GH and Dopa Mucuna. I think I will be running 5 days on 2 off with all of these products since I fear I will run into a negative feedback with elevated igf levels for too long.

 

[romanpiperva]

Never thought of huperzine for that! Awesome find/observation brother!

 

[Pepe Le-r3]

Thanks man! I also almost forgot to mention, Mk677 can slightly elevate cortisol. I will stack phosphatydilserine 3x a day. I'm also adding taurine and extra glycine with the phosphatydilserine because glycine's action is drastically increased by the other two.

 

[tballz]

Im not sure its worth running all this stuff on top of it. Id do it 5 days on, 2 off to minimize GHIH and cortisol and prolactin. Also I think stacking it would be a good idea. Either a cjc1293 or 1295 with dac would allow minimum pinning and definitely compound results. Let us know what you decide as far as how your going to run it ans what your going to run it with.

 

[Pepe Le-r3]

How do you suggest the dosing on the Mk 677? I can either dose once a day or 3x a day. I'm leaning towards 3x a day because I've read there is a spike at 12 hours, so it would mean several smaller spikes instead of one big one by dosing it through the day.

 

[j_p]

How do you suggest the dosing on the Mk 677? I can either dose once a day or 3x a day. I'm leaning towards 3x a day because I've read there is a spike at 12 hours, so it would mean several smaller spikes instead of one big one by dosing it through the day.

I would rec 1x ed IMO. or you may have non stop pumping of gh and i feel a spike or two is better than "GH BLEED" type of dosing and i also feel atleast a week off every few weeks or so is optimal. also ghrp2 doesnt last as long as MK IMO, which some complain about possible "GH BLEED" with longer acting compounds of this nature.)
this is still new to be in mainstream use, but I feel that a single dose is likely optimal, and gives time for levels to go down and then the next days dose to come in.
2x just maybe maybe... but 3x i feel safe to say no...

just my thinking on it anyway

 

[Pepe Le-r3]

You would take a week off, even when doing 5 days on and 2 off?

 

[romanpiperva]

I tend to agree with JP for the most part, one time a day. However taking time off I think is person dependent and goal dependent. Like myself with a pituitary deficiency who had the option of prescribed gh but use Peptide instead, I would never take a break. Other perfectly healthy men may want to take a week off after a month straight to make sure there is no suppression and again I haven't heard too much about it being that suppressive to the HPTA, but I also don't know/have read everything so let's keep it going on the topic of frequency!