Try some oxandrolone, credit to DatBTrue putting the references together, apologies for the formatting I'm using the EF App.
Oxandrolone
Nandrolone, Oxymetholone (in anemia) and Oxandrolone are the anabolic steroids most used in studies with benefit to healing. Androgenic receptors are found in the highest concentration in myocytes ad skin fibroblasts. Anabolic steroids increase protein synthesis and new tissue formation which shows up often as skin thickness and muscle formation. 59-63
The anti-catabolic actions come from decreasing protein breakdown induced by cortisol. 63 This may be my favorite effect.
Oxandrolone shows up the most in studies 61-70 because of it's superior anabolic to androgenic ration (very low androgenic sides) and because it's structure is such that it is metabolized and cleared in the Kidneys and not the liver. There is virtually no liver toxicity to contend with. It is easily absorbed by the intestines with 99% bioavailability with a half life of 9 to 12 hours.
Clinically oxandrolone has been used in HIV, COPD and spinal chord injury patients as well as burn patients and various trauma patients. In almost all studies there was increased healing and increased lean mass. In all the clinical trials where there was lean mass gain, 1.2 to 1.5g/kg per day of protein were consumed.
Clinical Effect of Oxandrolone (from the literature)
Attenuate the catabolic stimulus during the "stress response"
More rapid restoration of lost lean mass
Restore normal nutrient partitioning
Improved healing of chronic wounds with restoration of lost lean mass
Specific Effects on Wounds
In addition to the general effect there is direct stimulation of all phases of wound healing. 71-77 This comes from in vitro and animal studies.
Wound healing (In Vitro Human Fibroblasts)
Stimulation in messenger RNA for collagen synthesis
Stimulate collagen synthesis
Increases release of transforming growth factor-β (TGFβ)
Downregulation of expression of matrix metalloproteinase expression
Wound healing (Animal Studies)
Increase in wound closure (contraction)
Increase in collagen deposition
Increased re-epithelialization
Increased angiogenesis
Increased wound tensile strength
Briefly, the Erlich study reported a tenfold increase in the messenger RNA for collagen synthesis, in a human fibroblast culture with oxandrolone. 74 This effect was not unique to oxandrolone as the Falanga reported a stimulation of collagen synthesis with the anabolic steroid stanazol. 73
In a study by Tenenbaum there was an increased synthesis of bone, collagen, matrix, and epidermis in a wound of the oral cavity stimulated with oxandrolone. 75
In a study by Demling there was a reported strong increase in the healing of a cutaneous wound in the rat treated with oxandrolone compared to controls. A 50% increase in wound collagen was noted as well as a doubling of tensile strength at 3 weeks with oxandrolone as well as more densely packed collagen with more fibroblasts and mononuclear cells. 71
There is also a local release of growth factors from anabolic steroids as well which substantially contribute to healing.
59 - Sheffield, M., The effect of short term oxandrolone treatment on peripheral amino acid metabolism, J. Burn Care Rehab., 2, 127, 1999
60 - Lafferty, F., Effect of androgens, estrogens and high calcium intakes on bone formation and resorption in osteoporosis, Am. J. Med., 36, 514–528, 1969
61 - Karim, A., Oxandrolone disposition and metabolism in man, Clin. Pharmacol. Ther., 14, 862–866, 1973
62 - Mendenhall, C.I., A study of oral nutritional support with oxandrolone in malnourished patients with alcoholic hepatitis: results of a Department of Veterans Affairs Cooperative Study, Hepatology, 17, 564–570, 1993
63 - Hickson, R., Glucocorticoid antagonism by exercise and androgenic-anabolic steroids, Med. Sci. Sports Exer., 22, 331–340, 1990
64 - Stanford, A., Resistance exercise and supraphysiologic androgen therapy in eugonadal men with HIV related weight loss. A randomized placebo controlled trial, JAMA, 281, 1282–1290, 1999
65 - Demling, R.H., Oxandrolone, an anabolic steroid, enhances the healing of a cutaneous wound in the rat, Wound Repair Regen., 8, 97–102, 2000
66 - Demling, R.H., The anticatabolic and wound healing effects of the testosterone analog oxandrolone after severe burn injury, J. Crit. Care, 15, 12–17, 2000
67 - Demling, R.H., Involuntary weight loss and the nonhealing wound: the role of anabolic agents, Adv. Wound Care, 12, 1–14, 1999
68 - Demling, R.H., Comparison of the anabolic effects and complications of human growth hormone and the testosterone analog, oxandrolone, after severe burn injury, Burns, 25, 215–221, 1999
69 - Kim, C.S., The effect of anabolic steroids on ameliorating the adverse effects of chronic corticosteroids on intestinal anastomotic healing in rabbits, Surg. Gynecol. Obstet., 176, 73–79, 1993
70 - Schols, A., Weight loss is a reversible factor in the prognosis of chronic obstruction pulmonary disease, Am. Rev. Resp. Dis., 157, 1791–1797, 1998
71 - Demling, R.H., Closure of the "non-healing wound" corresponds with correction of weight loss using the anabolic agent oxandrolone, Ostomy Wound Manage., 44, 58–62, 1998
72 - Beiner, J.M., The effect of anabolic steroids and corticosteroids on healing of muscle contusion injury, Am. J. Sports Med., 27, 2–9, 1999
73 - Falanga, V., Stimulation of collagen synthesis by the anabolic steroid Stanazol, J. Invest. Dermatol., 11, 1193–1197, 1998
74 - Erlich, P., The influence of the anabolic steroid oxandrolone upon the expression of procollagen types I and II MRNA in human fibroblasts cultured in collagen or plastic, Wounds, 13, 66–72, 2001
75 - Tennenbaum, R., Effect of the anabolic steroid oxandrolone on wound healing, Oral Surg., 30, 834–835, 1970
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