This is interesting for me. I went to USC. My parents went to Oklahoma, and I've been cheering for them my entire life. If both teams win out...
Right now OU is the best there is by far. USC is second, but after watching both all season I'd have to conclude that SC would get killed by OU because of their pass defense.
As far as the Big 12 Championship goes, KSU would probably give OU the best game. Possibly Mizzou in a rematch - they didn't fare too bad, comparatively, in the first meeting. KSU does have a fair amount of team speed.
Title game - SC would play OU really hard, and history is on their side in the series - SC leads it 5-2-1 I believe. But OU would win out - they are just too damn good. The matchup between Stoops and Norm Chow would be pretty cool to see though.
If OSU somehow makes it - OU will dismantle them. Their offense is just too weak. Their defense will attempt to make it a game, but just a few slipups and they're screwed.
LSU - haven't seen them play, but from what I've heard they might actually be the team to play OU.
Onto another sick thought...OU plays Baylor this weekend. A&M beat Baylor 73-10. OU beat A&M 77-0. You do the math.