Beware the effects of Anastrazole

[NFG123]

Hey all.

I just stopped mid cycle because my cholesterol was 271 and ldl was 232, hdl 11. I am recovering now, and want to warn people of what liquidex may due to you. Post cycle for the cycle I had before this, my values were 191 and 34 total hdl. Not great, but not nearly as bad as this. I started trenbolone about 6 weeks ago, at 75 mg ED. this shut down my natural testosterone production, so I had no estrogen in my body (occurence from the conversion of testosterone to estrogen in males ... no testosterone = no estrogen). we all know estrogens play a very important role in maintaining serum lipid profiles. I then started test prop at 700 mg week, and added liquidex at 1 mg ED. Im sure this didnt help, still no estrogens.

Im not sure what to blame for my bad values, genetics arent a big factor for me, and I was following one of quadsweeps diets to the letter .... I wasnt eating shit.

I therefore suggest that everyone use nolvadex with your cycles, EVEN IF YOU ARENT TAKING TESTOSTERONE or an aromatizing steroid. This will help since tamoxifen has recently been shown to have moderate beneficial effects on lipids in males. If you must take liquidex, please take 20 mg ED tamoxifen (nolvadex) with it. I do not believe liquidex is necessary. Its safety is still in question ... not much research (yes AS arent safe either, but its a game we play ... why not minimize the risk)

Cardiovascular disease IMO is by FAR the worst side effect from AS use. I am not prone to anything else. No liver kidney stress .. no hair loss gyno or acne. No rage.

1: Horm Res 2002;57(5-6):187-91 Related Articles, Links


Effects of tamoxifen on lipid profile and coagulation parameters in male patients with pubertal gynecomastia.

Novoa FJ, Boronat M, Carrillo A, Tapia M, Diaz-Cremades J, Chirino R.

Department of Endocrinology, Hospital Universitario Insular, Las Palmas de Gran Canaria, Spain.

Background/Aim: The estrogenic actions of tamoxifen on lipid profiles and hemostasis have been extensively demonstrated in women. Due to limited experience with this drug in males, it is uncertain whether these effects are also present in men. The aim of our study was to assess the response of blood lipids, lipoproteins, and coagulation parameters in a group of men taking tamoxifen. Methods: We studied 15 healthy boys with pubertal gynecomastia who were given 10 mg tamoxifen per day. Total testosterone, sex-hormone-binding globulin, estradiol, serum lipids, apolipoprotein B, apolipoprotein A-I, lipoprotein(a), fibrinogen, antithrombin III, von Willebrand factor, and markers of activated coagulation and fibrinolysis were determined at baseline and 1 and 3 months after beginning of the tamoxifen treatment. Results: Total cholesterol and lipoprotein(a) showed moderate but significant decreases from baseline. Low-density lipoprotein and high-density lipoprotein cholesterol concentrations as well as triglyceride and apolipoprotein B levels became lower, but these changes were not statistically significant. Among clotting parameters, antithrombin III was reduced, and von Willebrand factor increased significantly. Markers of activated coagulation and fibrinolysis remained unchanged throughout the period of therapy. Conclusions: The effects of tamoxifen on blood lipids and hemostasis we found in this group of healthy young men were qualitatively similar, but lesser than those previously described in women. Copyright 2002 S. Karger AG, Basel

 

[NFG123]

^

 

[Sigmund Roid]

Mmm, I quoted the same article a few weeks ago. I agree. In hardcore cycles I recommend using anastrazole/letrozole low dosage together with clomid/nolvadex for obtaining estrogenic effects on the lipid profiles.

 

[drug_against_war]

Why not switch to femara? It's only slightly more expensive.

 

[gainerxxl]

Why not switch to femara? It's only slightly more expensive.

Femara is worse than Arimidex, cause estrogen is supressed even further. No estrogen=shitty lipid profile

 

[Spectre]

Right, but doesn't ones profile return to normal when off? I can clear see the problem if one is running 3mo on/off constantly. But for 1 or 2 cycles a year is this really that bad?

 

[siceone]

so how do we fix this problem

 

[The Terminator]

so how do we fix this problem

You could just run cycles without arimidex (risky though, especially with higher doses), include nolva (already mentioned), avoid saturated fats while on and off cycle, and include cardio activities (something I don't do).

 

[liftsiron]

Bump

 

[Ulter]

I think you are using the wrong comparison. This study is done with Nolva. Nolva, as you stated, blocks the E from the receptor and arimidex merely inhibits the aromatese from making too much estrogen. Taking Nolva will result in less available estrogen in men than arimidex does. Arimidex only reduces estrogen by 59% in men. The reason for using Arimidex instead of nolva is that it's a better method for reducing estrogen and it doesn't have the rebound effect nolva does when you stop. But Nolva stops more estrogen.