"You still have yet to prove to that one incidence (per workout) of momentary concentric failure will always result in hypertrophy regardless of an individuals biochemical individuality, training experience, age, anabolic drug usage, diet, recovery ability, etc. You guys don't have to explain H.I.T. or low-volume training to me, I've read all about it. Einstein1 used the analogy of a light switch. It would be nice if the human body was that simple but unfortunately it's not."
Yeah, the light switch comment was funny. The thing is, when you reach concentric failure all available fibers are fatigued and twitching at max frequency. The build-up of phosphate and hydrogen ions as a muscle fatigues is thought to contribute to the growth stimulus. It is only logical to conclude that training to failure would result in a larger accumulation of these metabolites and, therefore, produce a greater growth response. Since it is clear that muscles grow in response to tension and the time that they are required to produce this tension (resulting in microtrauma being done to the fibers), anything that prolongs the time under which they are contracting hard will also increase the growth stimulus. In this light, training to failure is definitely more efficient at stimulating muscular gains than stopping short of failure. Training to failure, in itself, IS a stimulus for muscle growth, although is not essential. If consistent overload is applied, and the nutritional support is there, you will grow.
There have been TONS of studies proving this true as well, although I don't usually like to rely on studies because they are often contradicting. But, there has been 35 studies done on one set VS multiple set training, and 33 of them showed one set training to be just as effective. The two that showed mutiple sets to be effective have been severely scrutinized for the poor research design.