Results of echocardiogram........

[Fonz]

EXCELLENT Post imformative post Fonz!
Fonz, do you suggest this supplementation regimn for everyone doing a heavy cycle and training with super high intensity?

I would think it would definitely make sense to maximize the amount of oxygen that gets delivered to the heart anytime doing a cycle right?

Yes. But people will just dismiss it as irrelevant. At our age we think we are indistructible, and we can get through any situation. I disagree. Health should ALWAYS be paramount in hindsight.

1. Heavy AAS usage + Heavy weights = Great strain on heart (It needs this extra oxygen boost to remain healthy)(Normally applies to competitive BB'ers)
A good way to gauge wether or not you're taking way to much gear is your BP. BP is proportional to hematocrit levels(The solid component of the blood). A BP of 150 is approx. a Hematocrit of 50-55 which is VERY high. At a heamtocrit level of 60(BP in the 160-165 range), you die from internal blood coagulation that blocks the arteries and cause a myocardial infarction. Thats what happenned to the people that abused EPO.

or,

2. AAS usage long term + cardio/weights = strain on heart that adds up over time.(Normally applies to athletes)(But same deal with #1, the heart needs the extra oxygen boost to remain healthy)

In terms of internal organ damage, the liver is the easiest to cure(or get back to normal), then its the heart, and then the kidneys...for which once you cause damage its irreversible. Staying hydrated helps with the kydneys...but thats about it. I have yet to find a supplement to protect them not better than water or any drink thats water+flavouring...like crystal light.

Fonz

 

[wnt2bBeast]

Galaxy sorry i cant offer you a solution just wanted to say hope everything works out for you..good luck bro

 

[Bulldog_10]

How exactly do those things increase oxygen transport to the heart? I have my doubts.

 

[Burning_Inside]

not to be a dick, and i dont know if anyones mentioned this already, but did you ever think of mmmmmaybeeee laying off the gear? lol.
Unless you're on it for medical reasons and can't come off.

 

[Bulldog_10]

How exactly do those things increase oxygen transport to the heart? I have my doubts.

 

[Fonz]

1: Arzneimittelforschung. 1998 Jan;48(1):13-21. Related Articles, Links


Cardioprotective effects of dihydrolipoic acid and tocopherol in right heart hypertrophy during oxidative stress.

Thurich T, Bereiter-Hahn J, Schneider M, Zimmer G.

Gustav-Embden-Zentrum der Biologischen Chemie, Arbeitsgruppe Membranstruktur.

Rat hearts hypertrophied by exposure of the animals to low oxygen pressure were perfused by the Langendorff technique. After oxidative stress induced by hypoxia/reoxygenation, functional recovery of the hypertrophied right heart was insufficient when compared to non-hypertrophied controls. Accordingly, mitochondrial membrane potential did not recover sufficiently. There was a positive trend for improvement of the rate-pressure product during reoxygenation in lipoic acid (CAS 1077-28-7; 0.8 mumol/l) treated hearts which was also verified for membrane potential. Adenosine 5'-triphosphate and creatine phosphate contents as well as the ATP/ADP ratio in hypertrophied right ventricle were significantly increased after reoxygenation in hearts treated with lipoic acid. With lipoic acid, there was a significantly higher content of glutathione (oxidized form) after reoxygenation, Ca2+ uptake was significantly increased in mitochondria isolated from hypertrophied right ventricles and treated by 12 nmol/mg protein of lipoic acid. The results reveal a distinct improvement of mitochondrial structure/function by lipoic acid and suggest for therapy a combination with the synergistic free radical scavenging properties of tocopherol (CAS 10191-41-0).
PMID: 9522025 [PubMed - indexed for MEDLINE]

Regarding Acetyl-Lcarnitine:

1: Ann N Y Acad Sci. 2002 Apr;959:491-507. Related Articles, Links


Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid.

Hagen TM, Moreau R, Suh JH, Visioli F.

Department of Biochemistry and Biophysics, Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA. [email protected]

Mitochondrial decay has been postulated to be a significant underlying part of the aging process. Decline in mitochondrial function may lead to cellular energy deficits, especially in times of greater energy demand, and compromise vital ATP-dependent cellular operations, including detoxification, repair systems, DNA replication, and osmotic balance. Mitochondrial decay may also lead to enhanced oxidant production and thus render the cell more prone to oxidative insult. In particular, the heart may be especially susceptible to mitochondrial dysfunction due to myocardial dependency on beta-oxidation of fatty acids for energy and the postmitotic nature of cardiac myocytes, which would allow for greater accumulation of mitochondrial mutations and deletions. Thus, maintenance of mitochondrial function may be important to maintain overall myocardial function. Herein, we review the major age-related changes that occur to mitochondria in the aging heart and the evidence that two such supplements, acetyl-l-carnitine (ALCAR) and (R)-alpha-lipoic acid, may improve myocardial bioenergetics and lower the increased oxidative stress associated with aging. We and others have shown that feeding old rats ALCAR reverses the age-related decline in carnitine levels and improves mitochondrial beta-oxidation in a number of tissues studied. However, ALCAR supplementation does not appear to reverse the age-related decline in cardiac antioxidant status and thus may not substantially alter indices of oxidative stress. Lipoic acid, a potent thiol antioxidant and mitochondrial metabolite, appears to increase low molecular weight antioxidant status and thereby decreases age-associated oxidative insult. Thus, ALCAR along with lipoic acid may be effective supplemental regimens to maintain myocardial function.Publication Types:
Review
Review, Tutorial

PMID: 11976222 [PubMed - indexed for MEDLINE]



Any more questions?

 

[GoldenDelicious]

oh and just so you know, i went easy on your post.

if i wanted to, i could pick a few more gaping holes in that travesty that some people here have accepted as good advice. If you decide to get smart, fonz (as i know you will...you just cant control yourself) i will respond by going back into that post and unveiling how inept you really are. (although i suppose the word "unveil" isnt strictly the correct word to use when referring to your ineptitude...its kind of like unveiling a whores vagina. everyones already seen the damn thing)

moral of the story: amoeba brains should not give medical advice.

 

[faller]

One way to manage blood pressure (which should help a little) is to gorge on fruits, veggies, low fat dairy and nuts. Follow some form of the DASH diet (dietary approaches to stop hyptertension). It's been proven to work many times over (and works best with a salt restriction) and you should be able to get enough protein on it to not worry about losing muscle, you just might find yourself in the rest room often from the fiber. A side note, make sure you get in enough good fats while on this diet, as some people end up with so little fat intake that their HDL drops (eat lots of nuts).

 

[-SD-]

On for over 1year. High doses. Not really sure on family history. Im speaking with mother tonite.

So then you shoulndt be surprised at any of your heart conditions, right?

 

[dieselrhodes]

Goldendelicious, excellent post. I agree with your sentiment, that it is very dangerous for fools to offer medical advice. Have you had any experience with PVC's? What usually triggers them? What successful approaches to lessoning their frequency have you come accross? Unlike Fonz, please give me your personal experiences not a cut and paste job, thanks. Nothing personal Fonz, but I didn't appreciate the attack on a fellow board member who was just asking for advice with his heart problems.