i could not take any kind of thermo for to long,i have always had a problem with social anxiety and thermos just add to the problem,even clen fucks with me.doctors say its a chemical imbalance in the brain,when neuroephedrine levels become to high and/or to few neurotransmitters can cause a chemical imbalance like anxiety,depression.there are prescription meds that will help with the anixety like buspar,paxal zoloft .i am currently on paxil and now experance little or no anxiety with thermos.