Nolvadex and stroke scare

[small but working on it]

I have read a few threads in the last 6 months or so that discuss the possibility of having a stroke while on nolvadex ? It was brought to my attention again the other day with the thread about concerns about gear, heart, mental issues, addiction etc.. Basically what worries you the most about gear and someone stated that there was a study done that showed a percentage of men had strokes while on nolvadex, another bro (cant remember who) stated that he had indeed had a stroke and was coincidently was on nolvadex at the time. He said he couldnt be sure if it was connected to the nolva but it was a possibility. Can someone give me some info on this and some real research info or a site that shows the study ? I would hate to grow on gear and end up stroking out from my pct . If you dont know, please dont reply with Dont worry about it, it was probably one guy that didnt know what he was doing etc.... I am trying to protect myself and inform myself with facts. Thanks for your time.

 

[satchboogie]

i doubt it..

 

[small but working on it]

wouldnt you like to see a study that debunks it though Satch ? I kinda doubt it too but what if there is some validity to it, shouldnt we inform ourselves and have the knowledge to make an informed decision on what ancillaries to take ?

 

[Advisor_x]

In my years in BB this is the first time that I hear this............

 

[asianlover]

isn't nolva a commonly prescribed drug to women with breast cancer? i think if there was a significant chance of stroke it wouldn't be prescribed anymore.

 

[small but working on it]

I have read a total of 3 threads I think about it. I am not starting rumors and am just trying to get some advice on it and see if anyone else has heard this , thanks advisor.

 

[satchboogie]

id love to see some more info regarding this.
if you can find links and/or studies please share with us.

thanks.

 

[Ulter]

I kinda doubt it too but what if there is some validity to it....?

What if the moon falls out of the sky?

There is reason to avoid nolvadex. You're not going to get a stroke from it. That's ridiculous. 4/10 of one percent more women got a stoke while using it than those who were not using it. That's hardly cause for alarm. Those women had cancer to begin with.

 

[small but working on it]

Well Ulter, I understand your skepticism but you are talking about women taking the nolvadex and as we all know I am talking about men taking it. I havent seen any threads about any studies being done about the moon falling from the sky, if you are not familiar with the study or are skeptical that is fine but please dont write everything off because 4/10 of one percent of women who had cancer had a stroke. It is well known that different drugs have vastly different effects on men and women. Do YOU KNOW of a study involving men and nolvadex ? If not, why dismiss the possibility with the woman comparision. thanks

 

[Ulter]

No, I don't know about any study showing increased risk of stroke in men. And neither does the FDA because it would affect the warning label. My point was that people hear some idiot make a claim and they turn into chicken little and yell the sky is falling. Here.

Stroke risk and tamoxifen therapy for breast cancer.

Geiger AM, Fischberg GM, Chen W, Bernstein L.

Research and Evaluation Department, Kaiser Permanente Southern California, 100 S Los Robles, Pasadena, CA 91188, USA. [email protected]

BACKGROUND: Tamoxifen, which is used widely to treat, and increasingly to prevent, breast cancer, has been associated with increased risk of stroke. We assessed the impact of tamoxifen treatment for breast cancer on the risk of stroke, considering dose, duration, and recency of use of tamoxifen and known stroke risk factors. METHODS: We conducted a nested case-control study of stroke after breast cancer among female Los Angeles County residents enrolled in a large health maintenance organization when diagnosed with breast cancer between January 1, 1980, and July 1, 2000. We obtained information on breast cancer treatment and stroke risk factors through medical record review and telephone interviews. The association (odds ratio [OR] and 95% confidence interval [CI]) between tamoxifen and stroke risk was determined by using a conditional logistic regression model, adjusting for menopausal status and history of hypertension and diabetes. All statistical tests were two-sided. RESULTS: Of 11 045 women with breast cancer, 179 met stroke eligibility criteria and were individually matched to two stroke-free control subjects with breast cancer on age and year of breast cancer diagnosis. The mean age at breast cancer diagnosis was 66.6 years (standard deviation [SD] = 12.3 years), and the mean at-risk period (i.e., the time between breast cancer diagnosis and first stroke or comparable time period for control subjects) was 5.7 years (SD = 4.5 years). Tamoxifen use was not associated with risk of stroke, either overall (OR = 1.0, 95% CI = 0.6 to 1.6) or in subgroups defined by duration, dose, or recency of use. Chemotherapy, but not a specific chemotherapy regimen, was associated with an increased risk of stroke, regardless of tamoxifen use (no tamoxifen use, OR = 2.8, 95% CI = 1.3 to 6.3; tamoxifen use OR = 2.2, 95% CI = 1.2 to 4.1). CONCLUSIONS: Tamoxifen use is not associated with increased stroke risk. Further exploration of possible increased stroke risk following chemotherapy treatment for breast cancer is needed.