Is it true that Advil/Tylenol inhibits gains?

[mt]

I read somewhere that taking these pain killers like Advil will inhibit gains. Any truth to that and why would that be the case?

 

[silverbackn]

They inhibit protein synthesis to some extent. I don't really think there are any studies where guys juicing and using NSAIDS were compared to guys juicing and not using them. It's hard to say what real world effect they can have on gains. I stay away from them just to be on the safe side. I think painkillers, even OTC, are bad news.

 

[showstoppa2006]

I have never had a problem with ibuprofen products inhibiting any gains. As a personal trainer, I would say that they may be somewhat helpful in healing as they can reduce swelling and reducing swelling is key in the healing process of your muscles.

 

[mt]

I have never had a problem with ibuprofen products inhibiting any gains. As a personal trainer, I would say that they may be somewhat helpful in healing as they can reduce swelling and reducing swelling is key in the healing process of your muscles.

That's more along the lines of my thoughts and why I sometimes will use it. A previous post mentions that inhibits protein synthesis. How does it do that?

 

[Indy]

I read somewhere that taking these pain killers like Advil will inhibit gains. Any truth to that and why would that be the case?

Ronnie coleman takes NSAIDS everyday, dont look like they hurt him much.

 

[wayneboard1]

isn't the magic # 400 milligrams and then advil especially starts to mess with your protein synthesis?

 

[Indy]

isn't the magic # 400 milligrams and then advil especially starts to mess with your protein synthesis?

Not sure, but 800mg/day then it starts to mess with your liver pretty bad

 

[mt]

Ronnie coleman takes NSAIDS everyday, dont look like they hurt him much.

Well, his calves are a little light.... relatively speaking.

Anyway, how do you know this? Has he stated that openly? And why does he do it? Is his joints that screwed from lifting such heavy poundages that he needs NSAIDS to continue to train as he does?

 

[silverbackn]

They somewhat inhibit the cox-2 enzyme which is a key part to of the GAS response. Look it up in a physiology book. You will all fall asleep if I try to explain it. It in some sense curves the adaptive response by putting your body in a less alarmed state in response to muscle trauma (soreness).