I don't think that has merit...Dr.Scott Connelly,who basically brought the importance of glutamine to the supplemental market and has studied it and every amino acid in existence for probably as long as any scientist includes about 5-6 grams of it in every packet of Met-rx..Most research I have seen on it recommends taking it in 5 gram intervals 2 to 4 times daily...Not sure on whether it should be taken on an empty stomach,but if the above article holds true,one should probably take it with an ample amount of carbs to release insulin,which would drive more of it into the cell.