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Bioactive Mimetic Loop

So 10-seconds of 'research' reveals (via Google AI) that it's a mis-use of an actual term: A bioactive mimetic loop is a synthetic structure designed to mimic the bioactive region of a larger molecule, often a protein or peptide, while retaining its biological activity. These mimetics are typically small, constrained peptides or other synthetic molecules that are designed to fold into a specific conformation that resembles the native loop. They are used in various applications, including drug discovery, protein engineering, and material science
So the idea as suggested says it's about carbs where as the other is very specifically protein based (peptides are made from amino acids and so protein based).

If it's a true shift use a different name. Do NOT use a term to mis-lead or confuse. It just muddies the water.

A better thought is why? Is there an actual need, even in a carb-biased strength training (I train for strength), for loads, more carbs?

I'll address briefly the 'strongman' angle. Those that train for strength and or as strongmen (and, as is the case here, do a semi-physical job) often require higher percentages of carbs than those of equal bodyweight who call themselves bodybuilders and train accordingly. That said the top athletes (WSM level) now are leaner than previously. Abs aren't unusual. Esp so (again as is the case here) in those who are not heavyweights. That's been true of ALL kinds of weight restricted lifters. It's NOT proof of concept. It's almost a given. If you're limited to 90kg or 198lbs you
want as much muscle and so strength as possible.

You don't need fullness in how the muscle appears to train for strength. I sometimes joke it's the bodybuilder in me that sees me looking in the mirror while lifting., But truthfully how I look does f'all for my benching etc. I do NOT need a six pack or bicep veins or fullness. Function is all.
One example of what many strongmen do throughout event training and on the day of competitions is consume Gummy Bears (the Glucose based kind) and the like in small amounts. It has NOTHING to do with insulin manipulation just energy to not be knackered and continue training etc. Event days can easily be 4 hours x 3-4 events and at near maximal levels.

There IS an issue of using ChatGPT/AI. One is suggesting parameters not understood and having ChatGPT or an AI, which has NO concept of understanding, to write anything. Spelling isn't an issue.

We HAVE discussed Nutrient Partitioning. It was the idea behind N2BM's N2Slin. It's literally a part of the methods you say other use now (or else why do them). Stevesmi and I have mentioned Tren's Nutrient Partitioning benefits many times on the podcasts. Arguably ALL AAS do so to some degree if only via the uptake and retention of nitrogen/ protein at greater than natty levels. I'd also argue, as you ought to know, YOU as a single individual are NOT proof. Science requires multiple studies, many more than single users etc. It's up there with the IIFYM and having ONE guru with a six pack as 'proof'.

I said in the other thread advances are more about understanding. There will be NO changing of how humans do what they do. That's evolution. The whole uber species, next step stuff, has been around 100's of years as an idea. You even, if indirectly, touch upon this yourself in pointing out in responding to your own title ''It doesn’t activate PI3K/Akt/mTOR."You don’t need to force that pathway 24/7 People get all excited by a discovery, esp when it comes to adding muscle or strength, and rush to hammer it to death. It was said in the 1950's that if mule piss added muscle Weider would have bottled it to sell and bodybuilders would buy it. You can, at best, push natural processes. To do more leads into bad health, feedback loops and worse (see also disastrous medical studies and outcomes).

The truth is this. You're weight restricted (not a super heavy). Young enough (no age related slowing down of metabolism), physically active in training and at work (been there done that) and self aware enough to eat well and cleanly (something many strength athletes do now). Do less work, eat poorly, switch jobs, train badly and see if you stop being lean and or respond as well. These parameters MUST be taken in consideration and would be in a study. How many such studies use students (young), the untrained and in a fasted state? Because it counts. By way of example I'm no more proof of concept in how I train compared to most. I'm among (if not THE actual strongest) the stronger on most forums. But I do a LOT less volume than most. Heck I probably eat a great deal of carbs too - inc white chocolate bars. Parts of me are lean (no abs though) but as a single example I'm not proof my way is new or better than anyone else is. It's also why most systems and advice are generalized and based on what works for the many and not the few.
 
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Yes.. I'll get to the log this weekend. News on this front though.. after talking yesterday I pushed the envelope. I did 700+ clean carbs and for the sake of my experiment I downed 2 chocolate bars and a piece of carrot cake in the evening to push over 800g carbs. I have pictures from this morning. The loop holds up not just with healthy carbs but I woke up this morning still tight (yes pics will be in log). I'm not a bodybuilder im training for strongman competition but will include my write up. Pictures, time stamps, supps, nutrition, milestones, starts stops, notes on my micro dosing halo, nutrition etc.. it's coming but as you can tell I'm playing with alot of stuff all at once and working FT at a demanding job (Millwright in a production plant). My notes are scattered and include alot of wordy summaries from my ChatGPT.. it's the only way I can get alot of these things compiled quickly while doing everything but it means sorting out through ChatGPT bs.

Yes. The parts AI doesn't 'get'. It is, at best, less time consuming if it IS clear. For those most part it is easy to see when a book etc is AI written (annoyingly repetitive for a start).

You'd be better off, IMO, just recording ideas and having AI 'write it out'. But you MUST read it. How we think and talk does NOT always translate well when written. And we're piss poor at proof reading our own work. I was great at it (still am) for others (I edited a magazine etc) but my late brother David would spot mistakes in my editorials I couldn't 'see'.

In all my replies it's me writing unless I quote something which I'm clear on when doing so. Not an AI.
 
You’re missing the point.

The Bioactive Mimetic Loop (BML) isn’t trying to be insulin. It’s designed to do insulin’s job—without the side effects.


1. "AMPK is catabolic."
Only if you're starving. In the BML, it’s used strategically to increase glucose uptake, improve insulin sensitivity, and keep your body in a fat-burning, carb-absorbing state.

2. "It doesn’t activate PI3K/Akt/mTOR."
You don’t need to force that pathway 24/7.
The loop primes the system so when insulin is released naturally post-meal or post-training, you get more bang for your buck.
Better absorption, less spillover, tighter look.

3. "600g carbs with abs doesn’t prove anything."
It does when it happens daily, with no fat gain, no bloat, and performance going up. That’s not under-eating or luck. That’s controlled partitioning.


What the BML actually is:

Berberine drives glucose into muscle

Carnitine improves fat burning and supports androgen activity

Salt + nutrient timing enhances absorption

Training + AAS support creates the perfect demand curve


No insulin spikes. No fat gain. Just lean fuel loading on command.


You called it "glorified glucose management"?
Damn right.

Except it works. Every. Single. Day.
And for $1 a day, not $1,000/month in pharma.
You presume he is. That's insulting. It doesn't sell an idea to a willing crowd if you start with that angle.
 
So 10-seconds of 'research' reveals (via Google AI) that it's a mis-use of an actual term: A bioactive mimetic loop is a synthetic structure designed to mimic the bioactive region of a larger molecule, often a protein or peptide, while retaining its biological activity. These mimetics are typically small, constrained peptides or other synthetic molecules that are designed to fold into a specific conformation that resembles the native loop. They are used in various applications, including drug discovery, protein engineering, and material science
So the idea as suggested says it's about carbs where as the other is very specifically protein based (peptides are made from amino acids and so protein based).

If it's a true shift use a different name. Do NOT use a term to mis-lead or confuse. It just muddies the water.

A better thought is why? Is there an actual need, even in a carb-biased strength training (I train for strength), for loads, more carbs?

I'll address briefly the 'strongman' angle. Those that train for strength and or as strongmen (and, as is the case here, do a semi-physical job) often require higher percentages of carbs than those of equal bodyweight who call themselves bodybuilders and train accordingly. That said the top athletes (WSM level) now are leaner than previously. Abs aren't unusual. Esp so (again as is the case here) in those who are not heavyweights. That's been true of ALL kinds of weight restricted lifters. It's NOT proof of concept. It's almost a given. If you're limited to 90kg or 198lbs you
want as much muscle and so strength as possible.

You don't need fullness in how the muscle appears to train for strength. I sometimes joke it's the bodybuilder in me that sees me looking in the mirror while lifting., But truthfully how I look does f'all for my benching etc. I do NOT need a six pack or bicep veins or fullness. Function is all.
One example of what many strongmen do throughout event training and on the day of competitions is consume Gummy Bears (the Glucose based kind) and the like in small amounts. It has NOTHING to do with insulin manipulation just energy to not be knackered and continue training etc. Event days can easily be 4 hours x 3-4 events and at near maximal levels.

There IS an issue of using ChatGPT/AI. One is suggesting parameters not understood and having ChatGPT or an AI, which has NO concept of understanding, to write anything. Spelling isn't an issue.

We HAVE discussed Nutrient Partitioning. It was the idea behind N2BM's N2Slin. It's literally a part of the methods you say other use now (or else why do them). Stevesmi and I have mentioned Tren's Nutrient Partitioning benefits many times on the podcasts. Arguably ALL AAS do so to some degree if only via the uptake and retention of nitrogen/ protein at greater than natty levels. I'd also argue, as you ought to know, YOU as a single individual are NOT proof. Science requires multiple studies, many more than single users etc. It's up there with the IIFYM and having ONE guru with a six pack as 'proof'.

I said in the other thread advances are more about understanding. There will be NO changing of how humans do what they do. That's evolution. The whole uber species, next step stuff, has been around 100's of years as an idea. You even, if indirectly, touch upon this yourself in pointing out in responding to your own title ''It doesn’t activate PI3K/Akt/mTOR."You don’t need to force that pathway 24/7 People get all excited by a discovery, esp when it comes to adding muscle or strength, and rush to hammer it to death. It was said in the 1950's that if mule piss added muscle Weider would have bottled it to sell and bodybuilders would buy it. You can, at best, push natural processes. To do more leads into bad health, feedback loops and worse (see also disastrous medical studies and outcomes).

The truth is this. You're weight restricted (not a super heavy). Young enough (no age related slowing down of metabolism), physically active in training and at work (been there done that) and self aware enough to eat well and cleanly (something many strength athletes do now). Do less work, eat poorly, switch jobs, train badly and see if you stop being lean and or respond as well. These parameters MUST be taken in consideration and would be in a study. How many such studies use students (young), the untrained and in a fasted state? Because it counts. By way of example I'm no more proof of concept in how I train compared to most. I'm among (if not THE actual strongest) the stronger on most forums. But I do a LOT less volume than most. Heck I probably eat a great deal of carbs too - inc white chocolate bars. Parts of me are lean (no abs though) but as a single example I'm not proof my way is new or better than anyone else is. It's also why most systems and advice are generalized and based on what works for the many and not the few.

The name doesn't matter. Call it BML, call it Flufffy bunny carb cycling doent matter. If you done more than google what mimetic meant youd have learned something past what you currently know. It’s just a performance system. I train 7 days a week, work full time as a millwright that’s brain and body both going every day. I built this to handle high demand, simple as that.. most of the time I wouldn't need mass carbs but I have goals and closing on 40 I'll take every edge I'm afforded.

Yeah yeah, one person isn’t proof.
I never said I was. But where do systems start? Right here. Not in some study, but in the gym and people's kitchens being used, being tested. I track what I eat, what I lift, how I sleep, how I recover. If it holds up under pressure, under load, day after day? I want know what my body is going to be able to take not just today but next week. Even running lower carbs with this just makes the use of them more efficient plain and simple.
But if you're training every day, pushing 90 mins to 2 hours, doing strongman, compound lifts, carries, bracing drills and then grinding through a full shift on the tools, you’re gonna need fuel. This isn’t just about pump or looks or whatever. This is about lasting through the whole damn session and not crashing out.

Yeah, strongmen eat candy during events. That’s just patchwork emergency mode. This is mapped out. Carbs go in before, during, and after. Blood sugar stays level. Energy output doesn’t fall off a cliff. You’re not dragging halfway through, you’re still driving. It ain’t just “more carbs,” it’s smarter carbs l. AAS do improve partitioning, yeah, of course. But BML makes that actually mean something. You’re absorbing more great so Then feed it what it can use, when it can use it. Not just pounding food and hoping it lands right. This sharpens the edge, even works clean. Fuel in, force out.

I never said you need abs to move weight. But if I’m training hard, not eating trash, and I’m still staying lean while pushing ridiculous carbs that says something is working. It’s not about vanity, it’s just feedback. That’s how you know the system is dialed in. I use AI to write my shit out and catalogue. I don't need it to tell me how a system works. Even if I assume it's telling me something I double check the information I get. It's a shortcut not a doctor or a person and it didn't create the loop I did out of trial and error and with reading about how my body uses substances and food.
 
The name doesn't matter. Call it BML, call it Flufffy bunny carb cycling doent matter. If you done more than google what mimetic meant youd have learned something past what you currently know. It’s just a performance system. I train 7 days a week, work full time as a millwright that’s brain and body both going every day. I built this to handle high demand, simple as that.. most of the time I wouldn't need mass carbs but I have goals and closing on 40 I'll take every edge I'm afforded.

Yeah yeah, one person isn’t proof.
I never said I was. But where do systems start? Right here. Not in some study, but in the gym and people's kitchens being used, being tested. I track what I eat, what I lift, how I sleep, how I recover. If it holds up under pressure, under load, day after day? I want know what my body is going to be able to take not just today but next week. Even running lower carbs with this just makes the use of them more efficient plain and simple.
But if you're training every day, pushing 90 mins to 2 hours, doing strongman, compound lifts, carries, bracing drills and then grinding through a full shift on the tools, you’re gonna need fuel. This isn’t just about pump or looks or whatever. This is about lasting through the whole damn session and not crashing out.

Yeah, strongmen eat candy during events. That’s just patchwork emergency mode. This is mapped out. Carbs go in before, during, and after. Blood sugar stays level. Energy output doesn’t fall off a cliff. You’re not dragging halfway through, you’re still driving. It ain’t just “more carbs,” it’s smarter carbs l. AAS do improve partitioning, yeah, of course. But BML makes that actually mean something. You’re absorbing more great so Then feed it what it can use, when it can use it. Not just pounding food and hoping it lands right. This sharpens the edge, even works clean. Fuel in, force out.

I never said you need abs to move weight. But if I’m training hard, not eating trash, and I’m still staying lean while pushing ridiculous carbs that says something is working. It’s not about vanity, it’s just feedback. That’s how you know the system is dialed in. I use AI to write my shit out and catalogue. I don't need it to tell me how a system works. Even if I assume it's telling me something I double check the information I get. It's a shortcut not a doctor or a person and it didn't create the loop I did out of trial and error and with reading about how my body uses substances and food.

I don't like cutting and right now flat out into what normally require a 2-3 week cut at least to drop fat reserves all I'm gonna have to do is drop to maintenance calories and keep lifting as per normal.

So fuck cutting I'm gonna stick to the fluffy bunny carb loop.
 
I don't like cutting and right now flat out into what normally require a 2-3 week cut at least to drop fat reserves all I'm gonna have to do is drop to maintenance calories and keep lifting as per normal.

So fuck cutting I'm gonna stick to the fluffy bunny carb loop.
@rüd straight up bro when you going to start a log? we been waiting all this talk
 
@rüd straight up bro when you going to start a log? we been waiting all this talk
I was forcibly downgraded from laptop to just phone atm.. ordered a new tablet/keyboard but itll be a few days (i cant stand paying full price for anything). I really don't feel like trying to put my log up using my phone.. But I'll start it tonight. Just profile summary basics and pic from end of last cut and first day going onto cycle.. then just add to it with nutrition, supps as comments onto it? I'll take an honest look at a few logs on here and try to replicate loosely what's done.
 
The name doesn't matter. Call it BML, call it Flufffy bunny carb cycling doent matter. If you done more than google what mimetic meant youd have learned something past what you currently know. It’s just a performance system. I train 7 days a week, work full time as a millwright that’s brain and body both going every day. I built this to handle high demand, simple as that.. most of the time I wouldn't need mass carbs but I have goals and closing on 40 I'll take every edge I'm afforded.

Yeah yeah, one person isn’t proof.
I never said I was. But where do systems start? Right here. Not in some study, but in the gym and people's kitchens being used, being tested. I track what I eat, what I lift, how I sleep, how I recover. If it holds up under pressure, under load, day after day? I want know what my body is going to be able to take not just today but next week. Even running lower carbs with this just makes the use of them more efficient plain and simple.
But if you're training every day, pushing 90 mins to 2 hours, doing strongman, compound lifts, carries, bracing drills and then grinding through a full shift on the tools, you’re gonna need fuel. This isn’t just about pump or looks or whatever. This is about lasting through the whole damn session and not crashing out.

Yeah, strongmen eat candy during events. That’s just patchwork emergency mode. This is mapped out. Carbs go in before, during, and after. Blood sugar stays level. Energy output doesn’t fall off a cliff. You’re not dragging halfway through, you’re still driving. It ain’t just “more carbs,” it’s smarter carbs l. AAS do improve partitioning, yeah, of course. But BML makes that actually mean something. You’re absorbing more great so Then feed it what it can use, when it can use it. Not just pounding food and hoping it lands right. This sharpens the edge, even works clean. Fuel in, force out.

I never said you need abs to move weight. But if I’m training hard, not eating trash, and I’m still staying lean while pushing ridiculous carbs that says something is working. It’s not about vanity, it’s just feedback. That’s how you know the system is dialed in. I use AI to write my shit out and catalogue. I don't need it to tell me how a system works. Even if I assume it's telling me something I double check the information I get. It's a shortcut not a doctor or a person and it didn't create the loop I did out of trial and error and with reading about how my body uses substances and food.
100% agreed on your work load and said as much in a reply

The name was wrong. You agree. Rename it. Simples

The fuel issue is, arguably, everything here. What remains is performance. Has that improved? Not the sense of energy (which is ok) but actual uptick in lifts etc

I explained why you have abs. We both know why. I also pointed out that 'looking full' is a BB and NOT a SM thing. How you look is secondary. By way of example, from time to time, I see more veins. My start a million years ago as a BB, might make me feel 'oh nice... look at me all lean n shit' but does nothing for benching etc.

The issue with AI was explained. Obviously YOU input information (little actual data as such as it's still new to you). I'll cover the AI thing again.

Lots of students have used ChatGPT and similar to help write their essays. Most of those who do the marking have learnt to tell when it's AI. I've got a few of books assisted by AI. And it often reads poorly. That means when info inputted is then 'written' up and pasted here members felt that they could see it was AI. What I'd do (and might soon) is use it to organize my thoughts and then, if I can (I explained why that can be difficult) edit it into a more readable format.

IF people can read it and not feel like they're listening to an AI assembled bunch of info it will 'scan', read or 'sell' better. Which means more reach and engagement.
 
@rüd straight up bro when you going to start a log? we been waiting all this talk
Started it last night with absolute basics. Just supps, stack and nutrition. Notes, pictures and observations to come. They'll be slow and and with as much of me writing it as possible so SteveMobster's head doesn't explode.
 
Started it last night with absolute basics. Just supps, stack and nutrition. Notes, pictures and observations to come. They'll be slow and and with as much of me writing it as possible so SteveMobster's head doesn't explode.
lol @SteveMobsterG wont explode bro @rüd
where the log at? you need to post it here are instructions

HOW-TO LOG?

To really guide you we need more info from you.
  • Please share your diet, training, cardio, sleep, supplements etc log with us in a NEW thread, full log journal so our guidance is based on facts you provide.
  • It will take 15-20 minutes max.
  • We have 100s of years of experience between us, so you need to post a LOG Journal with your stats (weight,height,age, years training, cycle history) diet, training, cardio, supplement, sleep details. If you don't log what you eat or train now, open NOTES on phone and start recording it there and paste here. Very easy.
Please post a Log Journal asap for us

Please click the anabolic forum
top RIGHT, you see: +POST THREAD
click that

in Title: write your cycle name, like> My _____ Cycle Log
___ = the name of your log
example: My Training Nutrition Log
in body: write your planned cycle or cycle you doing now, your diet, training and we will help you along on your cycle

here are examples of LOG Journals

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