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HCG doesn't aromatize but it raises T, which in turn aromatizes. Osta raises T also, so...
Why/How does Osta cause gyno ?
- Thread starter Oxbow
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northernknight
New member
No, Ostarine or other SARMs do not raise Testosterone. Although Osta and LGD can cause some minor Estrogenic activity in some people, it has nothing to do with them raising Test levels, simply because they have absolutely no effect on rising Test level.
It distantly reminds me of the way Adrol causes Estrogenic sides like bloat and gyno even though its not capable of aromatizing to Estrogens. That has been explained with many different theories like "receptor crossover", but none of them fit to SARMS.
Anyway, estrogenic activity caused by Ostarine and LGD is so weak that you just need an good AI to keep aromazation from your natural Tests or other compounds that you may be taking under control and you should be fine. That's why AIs help when on Osta or LGD, not be cause SARMS them selves would aromatize.
How do I know this? I've been switching between Osta and LGD about a year straight now, while also on at least TRT dose of Test, with and with out AI, with SERM etc., and had bloodwork done about every two months. IOW I've experimented with SARMS in controlled environment using different variables, and read about the results mentioned above from my bloodwork.
Actually anadrol causes gyno from progesterone. It could be that Osta does the same. And Osta may not raise T levels but it still causes androgenic activity, so, once again... who knows? There's still that is a lot unknown about it.
northernknight
New member
I agree with you about 90%, since we are still learning new things about AAS discovered over 50 years ago, there certainly is lot more to learn about Ostarine and SARMs in general.
However, Anadrol is not a Progestin, and I've never seen any claims that Ostarine would interfere with Progesterone receptor, since it's a SARM and specificly targets Androgen receptors, I would consider it nearly impossible.
I've red many different theories based on many different studies, about how and why Adrol causes Estrogenic side effects without being able to actually convert to Estrogens. In many cases it's been said to raise Prolactin or being a Progestin as you suggested, but personally what I've found to be most accurate, and what I base my arguments about it is very well stated in this text (I belive the author is Anthony Roberts):
"Since Anadrol 50 is derived from DHT, it cant actually convert to estrogen (via the aromatase enzyme), and its not a progestin or a compound with progestenic activity so the estrogenic (?) side effects produced by it are of a very mysterious nature. It has been speculated that perhaps it can stimulate the estrogen receptor without actually being converted to estrogen and that's about as plausible an explanation as Ive heard. However, things really get strange, when Oxymetholone has been used in studies to alter the female reproductive/menstrual cycle; in those cases, it has lowered plasma progesterone levels! (7)"
Anyway, Anadrol a topic for a different thread, and I'm not trying to start an argument with you about it, just stating my own opion own the subject...
@ nothernknight Do you think an AI is enough for preventing Osta gyno ? Actually on TRT it means you reduce your oestrogen levels just to limit oestrogen activity induced by Osta, right ? Isn't it a bad think to have a low Oestrogen level ? I mean, you need this hormone to live.
Second thing, what do you think about Nolvadex with Osta ?
Second thing, what do you think about Nolvadex with Osta ?
Drol isn't a progestin just like Dbol isn't a estro, but it seems to aggravate that activity in many people. But not all. At any rate, I agree, there are still a lot of unknowns. But at least human grade drugs are studied. Research chemicals are essentially experiments or things that have been passed over as not worthy of human usage. That's not to say they aren't effective, but it has to be addressed where the short comings might be.
northernknight
New member
OTC AI like Formestane or Arimistane/Androsta has done the job well for me, and bunch other guys running Ostarine or LGD.
Just like always when using an AI, key is to balance your dose to keep your E2 under control, not over do it. You definitely never want to crush your Estrogen levels (unless absolutely necessary ie. When treating gyno with Letro), its a horrible feeling, just keep it under control.
That's why good OTC AI should be more than enough for Ostarine and LGD-4033. I've been using Liquidex AI from N2BM lately, and really like it, it's strong enough with moderate dosing to keep E2 under control from my TRT, and keep any gyno symptoms from LGD-4033 & Osta away. (And I always get at least minor gyno symptoms from them, if I'm not using some kind of anti-estrogen)
I don't have anything against Nolva, I actually did one experimental LGD run using Nolva instead of AI, and everything worked out pretty much same as with AI. I wouldn't still recommend using it, Nolva can be a very harsh drug to some, and it's a bit tricky to come off it after a long time without Estrogen rebound. It will be lot easier to just keep your Estrogen levels under control with AI, and probably also healthier since there is no need to use heavier AIs like Adex or Letro which would influence your lipids.
EDIT: So IME Nolva is best used for gyno flare ups, it works fast and for most it works well, but an AI should be used to prevent the whole issue happening.
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