Standard self defense tactics are round in the chamber always, safety on. All the better if you carry a glock as theres no external safety to fuck with. In emergency you either arent going to think of racking the slide or you wont have time. If you dont feel comfortable carrying with a round in the chamber you are simply adding an extra step in the emergency self defense process, and therefore adding more risk to your life. If you can deal with that more power to you but i personally like every edge i can get since its my ass on the line in the event i have to draw down.