which steroids kick your immunity's ass?

[OMEGA]

Tren #1
too much EQ
too many orals ( any kind)
Clen

 

[soupeater]

In summary, the literature indicates that
supraphysiologic doses of AAS with an intact steroid
nucleus are immunosuppressive, while those with
alterations to the steroid nucleus are immunostimulatory.
Testosterone has been shown to decrease NK activity
and the number of lymphocytes by inhibiting the
differentiation of stem cells into B lymphocytes, thereby
depressing antibody production and resulting in a
reduction in immune function. Testosterone propionate
similarly depressed the immune system. In contrast,
treatment with testolactone, oxandrolone and stanozolol
improved immune function. While these effects were
long lasting, continuing to influence the immune system
several weeks after the administration of a single dose,
the effects of various dosing regimes and of treatment
with combinations of AAS have not been clearly
elucidated.
​

Clinical and experimental evidence suggests that
gonadal steroids regulate immunological function
[​

​

95,111]. Some studies suggest that AAS are
immunosuppressive [102,112-116], while others suggest
that AAS enhance immune function [117]. However, the
nature of their effects on the immune system depends
on the type of AAS used and the dose and timing of
administration. It has been shown that different AAS can
act in either immunosuppressive or immunostimulatory
manner [52,102,103,107].

​

Mendenhall​

​

et al. [103] also used intact and castrated
rats to test the effects of endogenous gonadal hormones.
The rats were treated for 8 days with oxandrolone
(1.1 mg/kg/day,) testosterone (1.1 mg/kg/day),
or oxandrolone combined with physiologic amounts of
testosterone (15 μg/day). After 8 days of treatment with
oxandrolone, intact animals experienced a 41% increase
in T cell proliferation function. Conversely, rats treated
with testosterone experienced a 36% reduction in T cell
proliferation function. Rats treated with oxandrolone
and physiologic testosterone gave results that were​

not significantly different to baseline. Therefore, any​

net immunostimulation was abolished by testosterone.
In general, castration resulted in an increase in
immune responses. Supraphysiologic doses of AAS,
as found during abuse, may mimic medical castration
by suppressing serum levels of gonadotropins (follicle-​

​

​

stimulating hormone and luteinizing hormone) and
testosterone [​

​

109]. However, treatment with oxandrolone
returned the DCH response in castrated rats to baseline
while treatment with oxandrolone and physiologic
testosterone produced an even greater suppression
(45%). Therefore only a direct immunosuppressive
effect was observed. These results appear to be linked
to the integrity of the steroid nucleus as those with
an intact steroid nucleus consistently produced an
immunosuppressive effect, while those with structural
alterations produced immunostimulation.​

The above 3 cut and pastes are what related to it. Looks like anavar might have a great boosting capacity. Although it doesn't directly say that deca will improve T count it does infer that being a steroid that has an altered steroid nucleus it will improve immune function. My big question is which steroids fall into that category? It seems like deca, winny, and var do but what about all the other popular ones that weren't mentioned in the article?

 

[ALIN]

around 5-6 years ago I did my first real (albeit short and low dosage) cycle with the infamous M1T. If I remember correctly it was 4 weeker at 5mg ED. At the end I got pneumonia and after being in the best shape of my life I lost 17 lbs, most of which I credit to the sickness. I researched and found out that many people got the 'M1T flu' and that it can lower your immunity. Anyways, just wanted to poll which steroids can lower one's immune system. Any comments are welcome.

Thanks

The ONLY AAS that has actually effected my well being and made me lethargic is when I was running TREN ACE 100MG daily with nothing else,,,no additional testosterone.

 

[Zyglamail]

Its not as easy as this one does and that one doesnt.....

the literature indicates that
supraphysiologic doses of AAS

and

Some studies suggest that AAS are
immunosuppressive [102,112-116], while others suggest
that AAS enhance immune function [117]. However, the
nature of their effects on the immune system depends
on the type of AAS used and the dose and timing of
administration.

There is a lot more to this than just the levels of AAS also but where your other hormone levels sit in comparison play a bit of a role as well. Having estradiol below or above accepted lab values greatly increases chances of various diseases as well.

 

[layinback]

In summary, the literature indicates that
supraphysiologic doses of AAS with an intact steroid
nucleus are immunosuppressive, while those with
alterations to the steroid nucleus are immunostimulatory.
Testosterone has been shown to decrease NK activity
and the number of lymphocytes by inhibiting the
differentiation of stem cells into B lymphocytes, thereby
depressing antibody production and resulting in a
reduction in immune function. Testosterone propionate
similarly depressed the immune system. In contrast,
treatment with testolactone, oxandrolone and stanozolol
improved immune function. While these effects were
long lasting, continuing to influence the immune system
several weeks after the administration of a single dose,
the effects of various dosing regimes and of treatment
with combinations of AAS have not been clearly
elucidated.
​

Clinical and experimental evidence suggests that
gonadal steroids regulate immunological function
[​

​

95,111]. Some studies suggest that AAS are
immunosuppressive [102,112-116], while others suggest
that AAS enhance immune function [117]. However, the
nature of their effects on the immune system depends
on the type of AAS used and the dose and timing of
administration. It has been shown that different AAS can
act in either immunosuppressive or immunostimulatory
manner [52,102,103,107].

​

Mendenhall​

​

et al. [103] also used intact and castrated
rats to test the effects of endogenous gonadal hormones.
The rats were treated for 8 days with oxandrolone
(1.1 mg/kg/day,) testosterone (1.1 mg/kg/day),
or oxandrolone combined with physiologic amounts of
testosterone (15 μg/day). After 8 days of treatment with
oxandrolone, intact animals experienced a 41% increase
in T cell proliferation function. Conversely, rats treated
with testosterone experienced a 36% reduction in T cell
proliferation function. Rats treated with oxandrolone
and physiologic testosterone gave results that were​

not significantly different to baseline. Therefore, any​

net immunostimulation was abolished by testosterone.
In general, castration resulted in an increase in
immune responses. Supraphysiologic doses of AAS,
as found during abuse, may mimic medical castration
by suppressing serum levels of gonadotropins (follicle-​

​

​

stimulating hormone and luteinizing hormone) and
testosterone [​

​

109]. However, treatment with oxandrolone
returned the DCH response in castrated rats to baseline
while treatment with oxandrolone and physiologic
testosterone produced an even greater suppression
(45%). Therefore only a direct immunosuppressive
effect was observed. These results appear to be linked
to the integrity of the steroid nucleus as those with
an intact steroid nucleus consistently produced an
immunosuppressive effect, while those with structural
alterations produced immunostimulation.​

The above 3 cut and pastes are what related to it. Looks like anavar might have a great boosting capacity. Although it doesn't directly say that deca will improve T count it does infer that being a steroid that has an altered steroid nucleus it will improve immune function. My big question is which steroids fall into that category? It seems like deca, winny, and var do but what about all the other popular ones that weren't mentioned in the article?

intersesting read, but it's still a bit ambiguous.

check out the studies on ox, andadrol , nandrolone and test in hiv
postitive peeps. they're certainly paying attention to immune
function in these real world studies. of course there's an over
all improvement in health-well being, but no T cell effect either
way. dosages are low to moderate by bb'ing standards and there
may be an entirely different effect at higher doses. oxandrolone
is usually 20 40 and 80 mgs. test is 100 200 400 and 600.

nandrolone is 50 100 200. anadrol is 1 mg - kg weight. studies are
usually 3 months duration. anywho, interseting stuff. you'll dig it.

 

[ArmaniAK47]

intersesting read, but it's still a bit ambiguous.

check out the studies on ox, andadrol , nandrolone and test in hiv
postitive peeps. they're certainly paying attention to immune
function in these real world studies. of course there's an over
all improvement in health-well being, but no T cell effect either
way. dosages are low to moderate by bb'ing standards and there
may be an entirely different effect at higher doses. oxandrolone
is usually 20 40 and 80 mgs. test is 100 200 400 and 600.

nandrolone is 50 100 200. anadrol is 1 mg - kg weight. studies are
usually 3 months duration. anywho, interseting stuff. you'll dig it.

There is an effect on T cell count..

watch "bigger, stronger, faster."

 

[layinback]

There is an effect on T cell count..

watch "bigger, stronger, faster."

i saw it. cool documentary by the way. what part are you referring to?

 

[ArmaniAK47]

Aids guy that hopped on Oxandrin trial at high dose.

He seems to be taking other AAS as well, I didn't see the full clip of him.

 

[layinback]

Aids guy that hopped on Oxandrin trial at high dose.

He seems to be taking other AAS as well, I didn't see the full clip of him.

we've already concluded that overall health which leads to improved
immune function..

we are talking about DIRECT effect on T 4 cells.

 

[ArmaniAK47]

He said his T cells went from like 3 to 400 or some shit... watch the clip with him in it again.