t3 dosage timing

[pentatonic]

9 hour half life if I recall. Twice a day. Empty stomach. Oral. Do not "shoot." Follow the more is not better protocol. Taper at the end over a couple weeks (or less, depending on the dose you reached) down to as low as 12.5mcgs to try and avoid rebound as much as possible. 8 week cycles are common, but I've personally ran longer with no adverse side effects. 35mcg seems to be the sweet spot for me, as well.

Yeah, I went back and did a search on it and came back with anything from 10 hours to 2.5 days.

Cytomel
Liothyronine Sodium
Cytomel - Cytomel Side Effects - Cytomel Information
Pharmacology: Liothyronine is a synthetic form of the natural thyroid hormone, 3,5,3'-triiodothyronine. It has all the pharmacological activities of the natural substance. Thyroid hormones are believed to exert most of their actions through control of protein synthesis. At moderate concentrations, they increase the synthesis of RNA and protein, followed by an increase in basal metabolic rate; they stimulate oxidative enzyme systems, enhance the release of free fatty acids from adipose tissue, and increase the intestinal absorption and peripheral utilization of glucose. At higher concentrations, they decrease protein synthesis, uncouple oxidative phosphorylation and increase the breakdown of glycogen, lipids and protein.

Liothyronine is readily available to body tissues. Following oral administration, about 95% of the dose is absorbed from the gastrointestinal tract in 4 hours. The onset of activity of liothyronine is rapid, occurring within a few hours. Maximum pharmacological response occurs within 2 or 3 days, providing early clinical response. The biological half-life is about 2.5 days. The drug has a rapid cut-off of activity, which permits quick dosage adjustment and facilitates control of the effects of overdosage, should they occur. Liothyronine is metabolized to deiodinated and conjugated metabolites which are excreted in the urine.

 

[jmead]

ya i got the same results from my research.. im gonna go with the twice a day approach.. 25/25/25/25/25/50/50/50/50/50/50/75/75/75/75/75/75/50/50/50/50/50/50 and so on, until i get to 12.5 then possibly run that for 2 weeks
who knows ill figure the taper out later, just wondering about dosing but from how it seems it can range from every 10 hours to once a day.. o well im gonna go with twice a day split dosage

 

[goldenthree]

Here is an interesting idea for what to do post t3 cycle.

Supraphysiological cyclic dosing of sustained release T3 in order to reset low basal body temperature.

* Friedman M,
* Miranda-Massari JR,
* Gonzalez MJ.

Friedman Clinic, Montpelier, VT, USA.

The use of sustained release tri-iodothyronine (SR-T3) in clinical practice, has gained popularity in the complementary and alternative medical community in the treatment of chronic fatigue with a protocol (WT3) pioneered by Dr. Denis Wilson. The WT3 protocol involves the use of SR-T3 taken orally by the patient every 12 hours according to a cyclic dose schedule determined by patient response. The patient is then weaned once a body temperature of 98.6 degrees F has been maintained for 3 consecutive weeks. The symptoms associated with this protocol have been given the name Wilson's Temperature Syndrome (WTS). There have been clinical studies using T3 in patients who are euthyroid based on normal TSH values. However, this treatment has created a controversy in the conventional medical community, especially with the American Thyroid Association, because it is not based on a measured deficiency of thyroid hormone. However, just as estrogen and progesterone are prescribed to regulate menstrual cycles in patients who have normal serum hormone levels, the WT3 therapy can be used to regulate metabolism despite normal serum thyroid hormone levels. SR-T3 prescription is based exclusively on low body temperature and presentation of symptoms. Decreased T3 function exerts widespread effects throughout the body. It can decrease serotonin and growth hormone levels and increase the number of adrenal hormone receptor sites. These effects may explain some of the symptoms observed in WTS. The dysregulation of neuroendocrine function may begin to explain such symptoms as alpha intrusion into slow wave sleep, decrease in blood flow to the brain, alterations in carbohydrate metabolism, fatigue, myalgia and arthralgia, depression and cognitive dysfunction. Despite all thermoregulatory control mechanisms of the body and the complex metabolic processes involved, WT3 therapy seems a valuable tool to re-establish normal body functions. We report the results of 11 patients who underwent the WT3 protocol for the treatment of CFS. All the patients improved in the five symptoms measured. All patients increased their basal temperature. The recovery time varied from 3 weeks to 12 months.

 

[jmead]

read it twice now.. still confused.. wheres the part talkin about post t3 cycle therapy.. im just seeing the administration of t3 and dosing and length

 

[dr_skier]

bump

 

[goldenthree]

Sorry the study is just more evidence that weaning is definitely the way to go, and using a thermometer is a great way to do it.

 

[Knights2]

i just got ym t3 and my clen. i was going to split my t3 into two tiems a day and follwo the same dosgae as u bro

 

[KonikPolny]

@goldenthree. Whenever you hear about Dr. Denis Wilson or Wilson (Temperature) Sydromme (not to be confused with a legitimate, unrelated to metabolism, autosomal recessive genetic disorder called Wilson desease)head for the nearest exit. This is the ultimate quackery. I have read Wilson's book, I tried his "therapy" back in the late 90s, I cannot believe the alternative medicine community keeps endorsing this nonsens. Using cytomel for weeks and weeks to increase one's metabolic rate is plain dangerous and ineffective, unless you are seriously hypothyroid. In that latter case, you still need a mix of levothyroxine (T4) and cytomel (T3), not T3 alone.

 

[JayJo101]

I was thinking the half life was more like 35-45 hours.

Right the half life of T3 is approx one day, but T3 is known to peak in the blood for just a matter of hours (up to 10 hours AFAIK). That's why you should splitt the dose to get a constant blood concentration.

And make sure to take T3-PCT by RLS after your T3 run to speed up thyroid recovery.