cydex01 said:9 hour half life if I recall. Twice a day. Empty stomach. Oral. Do not "shoot." Follow the more is not better protocol.Taper at the end over a couple weeks (or less, depending on the dose you reached) down to as low as 12.5mcgs to try and avoid rebound as much as possible. 8 week cycles are common, but I've personally ran longer with no adverse side effects. 35mcg seems to be the sweet spot for me, as well.
Yeah, I went back and did a search on it and came back with anything from 10 hours to 2.5 days.
Cytomel
Liothyronine Sodium
Cytomel - Cytomel Side Effects - Cytomel Information
Pharmacology: Liothyronine is a synthetic form of the natural thyroid hormone, 3,5,3'-triiodothyronine. It has all the pharmacological activities of the natural substance. Thyroid hormones are believed to exert most of their actions through control of protein synthesis. At moderate concentrations, they increase the synthesis of RNA and protein, followed by an increase in basal metabolic rate; they stimulate oxidative enzyme systems, enhance the release of free fatty acids from adipose tissue, and increase the intestinal absorption and peripheral utilization of glucose. At higher concentrations, they decrease protein synthesis, uncouple oxidative phosphorylation and increase the breakdown of glycogen, lipids and protein.
Liothyronine is readily available to body tissues. Following oral administration, about 95% of the dose is absorbed from the gastrointestinal tract in 4 hours. The onset of activity of liothyronine is rapid, occurring within a few hours. Maximum pharmacological response occurs within 2 or 3 days, providing early clinical response. The biological half-life is about 2.5 days. The drug has a rapid cut-off of activity, which permits quick dosage adjustment and facilitates control of the effects of overdosage, should they occur. Liothyronine is metabolized to deiodinated and conjugated metabolites which are excreted in the urine.