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Frackal
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Well I found this little blurb:
"
- when insulin combines with its receptors on adipose & muscle tissue, GLUT-4 transporters stored in the cytoplasm in vesicles are translocated to the cell membrane & inserted by exocytosis.
- the cells can then take up glucose from the interstitial fluid by facilitated diffusion.
- When the insulin-receptor complex is inactivated, the GLUT-4 transporters are withdrawn from the membrane, & glucose entry into the cell declines.
- Cells maintain [ low ] of GLU on the inside by converting it to glucose-6-phosphate to facilitate further transporting"
So since ala is supposed to increase the amount of glut-4, would one conclude that it also increases the amount of amino acid delivery ? Or do glut-4 transporters only apply to glucose?
I had this idea:
Though for hypoglycemic risks I would never attempt it, I wonder what kind of synergy would be seen from insulin+r-ala...do insulin levels drop in the presence of increased r-ala--->glut 4 because r-ala somehow increases the amount of glut-4 transporters OUTSIDE the cell????? It doesnt seem to make sense that insulin levels would drop if it increased the glut-4 on the INSIDE of the cell because as stated above you would still need insulin to activate them....but is it possible to HAVE glut-4 transporters that sit on the cellular membrane?
So lets assume that you have a certain number of glut-4 transporters INSIDE the cell, you add r-ala which increases the number OUTSIDE the cell, making some of the glut-4 INSIDE the cell not needed.....some negative feedback loop lowers insulin in response to the increased r-ala.
You inject insulin and use r-ala as well, the exogenous insulin overrides the low insulin level caused by the extra r-ala, and brings those unused glut-4 transporters to the surface of the cell along WITH the ones already present from the r-ala, meaning you get kind of a synergistic or additive effect resulting in more nutrients in the cell...
Does this make any sense? Likely off base but my excuse is I am still a mid-semester Bio-111 student trying to recover from the 12 year mental coma I was in during public school
"
- when insulin combines with its receptors on adipose & muscle tissue, GLUT-4 transporters stored in the cytoplasm in vesicles are translocated to the cell membrane & inserted by exocytosis.
- the cells can then take up glucose from the interstitial fluid by facilitated diffusion.
- When the insulin-receptor complex is inactivated, the GLUT-4 transporters are withdrawn from the membrane, & glucose entry into the cell declines.
- Cells maintain [ low ] of GLU on the inside by converting it to glucose-6-phosphate to facilitate further transporting"
So since ala is supposed to increase the amount of glut-4, would one conclude that it also increases the amount of amino acid delivery ? Or do glut-4 transporters only apply to glucose?
I had this idea:
Though for hypoglycemic risks I would never attempt it, I wonder what kind of synergy would be seen from insulin+r-ala...do insulin levels drop in the presence of increased r-ala--->glut 4 because r-ala somehow increases the amount of glut-4 transporters OUTSIDE the cell????? It doesnt seem to make sense that insulin levels would drop if it increased the glut-4 on the INSIDE of the cell because as stated above you would still need insulin to activate them....but is it possible to HAVE glut-4 transporters that sit on the cellular membrane?
So lets assume that you have a certain number of glut-4 transporters INSIDE the cell, you add r-ala which increases the number OUTSIDE the cell, making some of the glut-4 INSIDE the cell not needed.....some negative feedback loop lowers insulin in response to the increased r-ala.
You inject insulin and use r-ala as well, the exogenous insulin overrides the low insulin level caused by the extra r-ala, and brings those unused glut-4 transporters to the surface of the cell along WITH the ones already present from the r-ala, meaning you get kind of a synergistic or additive effect resulting in more nutrients in the cell...
Does this make any sense? Likely off base but my excuse is I am still a mid-semester Bio-111 student trying to recover from the 12 year mental coma I was in during public school
