No heartburn here, but I HAVE had heartburn before from using r,s-ALA. You gotta be careful to wash it down VERY well with water...make sure it doesn't catch in your throat.
Two week results so far, no change in bodyweight for me or my partner. We're going another two weeks to test it over a full menstrual cycle since I can't be sure that I wouldn't have ordinarily lost/gained weight in those two weeks.
Noticeable effects:
For me, headaches, weakness, increased thirst, agitiation and trouble sleeping.