Liquidex Causing Serious Skin Dryness?

[EngiCream]

Re: Re: Liquidex Causing Serious Skin Dryness?

CoQ10 bites. r-ala is much better.

Fonz

This has nothing to do with skin but what about CoQ10 being used with DNP?

I ask because nandi originally posted this on Triedia.

1sttimer, I had an opportunity to do some reading this afternoon and found a study that reported coenzymeQ10 restores the contractile properties of heart muscle that have been depressed by DNP

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=6355490&dopt=Abstract

CoQ10 is a popular supplement that is readily available at health food stores, etc. I'm wondering if it wouldn't help skeletal muscle that was weakened by DNP as well.

Here's the study

1: J Mol Cell Cardiol 1983 Sep;15(9):595-602 Books, LinkOut


The restorative action of coenzyme Q10 in 2,4-dinitrophenol-depressed electrical and contractile activities of guinea-pig heart.

Furukawa K, Yamasaki Y, Kizu A, Furukawa K, Katsume H, Ijichi H, Kitamura K.

With electrophysiological methods, mechanisms of the restorative action of coenzyme Q10 (CoQ10) in 2,4-dinitrophenol-depressed electrical and mechanical activities of isolated guinea-pig hearts were studied. Isoproterenol (3 X 10(-8) M)-induced action potential and contraction of the heart in 27 mM KCl Tyrode solution were abolished by 6 X 10(-6) M 2,4-dinitrophenol, while the additional application of CoQ10 (50 micrograms/ml) restored both these activities of the heart. This restorative action of CoQ10 was dose related (2 to 50 micrograms/ml) and was inhibited by 10 micrograms/ml 15-hydroperoxyarachidonic acid (15-HPAA) or pretreatment of the animals with indomethacin (5 mg/kg i.v.). When exogenously applied, 200 ng/ml prostacyclin also restored the 2,4-dinitrophenol-depressed electrical and contractile activities of the heart, but this restorative action of prostacyclin was affected neither by 15-HPAA nor by indomethacin pretreatment. These results suggest the possible participation of prostacyclin in the restorative action of CoQ10 in 2,4-dinitrophenol-depressed electrical and mechanical activities of the heart.

PMID: 6355490 [PubMed - indexed for MEDLINE]

Or are you saying r-ala will do the things CoQ10 will do and more?

 

[Fonz]

Re: Re: Re: Liquidex Causing Serious Skin Dryness?

This has nothing to do with skin but what about CoQ10 being used with DNP?

I ask because nandi originally posted this on Triedia.



Here's the study



Or are you saying r-ala will do the things CoQ10 will do and more?

You may be on to something.
The reason ALA is taken is to raise glutathione levels(The cells
main anti-oxidant) in order
to protect the cell from the DNP generated free radicals.

Fonz

 

[bigazzmofo]

I think its more likely the drastic change in hormonal levels than the ldex itself. My skin always changes a lot at start of cycle and post cycle when hormone levels are fluctuating the most.

I htink I have to agree on this one. I have done Liquidex at those kinds of levels with no skin problems. My skin get's dry as a desert floor post cycle, especially right after my cycle, due to lack of hormones..

 

[Andy13]

Re: Re: Re: Liquidex Causing Serious Skin Dryness?

This has nothing to do with skin but what about CoQ10 being used with DNP?

You asked me to respond to this.. But I really haven't a clue as to what to say..

DNP is used often in biochemistry to study metabolism since it has a well-defined action in cells. You can assume that most of the studies that involve DNP use are exploiting this property of DNP to study some aspect of energetics, metabolism or the electron transport chain.

CoQ participates in the electron transport chain (ETC). It is a mobile electron carrier.
We know that DNP does not slow the (ETC), but, rather, makes it work harder to make the same amount of ATP. My guess is that these folks in the paper you posted tested the ability of CoQ to restore ATP generation (to some extent) in cells will added DNP. And since muscle contraction is strongly dependant on ATP concentrations, and increase in ATP means an increase in muscle contraction.

Usually in these types of experiments, they blast the cells with so much DNP that the results are often unapplicable to BBing.

In this case, they are studying the effects of a substrate WHILE under the influence of DNP, not following DNP as may be incorrectly interpreted by the wording in the paper.

Andy

 

[EngiCream]

Thanks for posting your thoughts on my question Fonz and Andy.