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Leukemia and Steriods
- Thread starter spastic_gramps
- Start date
Actually, it is well known that there are some cancers that ARE greatly affected by hormones, cause much greater growth....ie, prostate and androgens and breast and estrogen/progesterone (HER 1 and 2 genes).
WBCs wouldnt be, no androgen receptor, but they can stimulate the marrow to pump out red cells quicker...perhaps WBCs as well, dont know enough about that specificly...
WBCs wouldnt be, no androgen receptor, but they can stimulate the marrow to pump out red cells quicker...perhaps WBCs as well, dont know enough about that specificly...
spastic_gramps
New member
Wow. I had forgotten about this thread. I just had my third year biopsy and everything is clear. My prognosis is excellent.
I haven't done anything to this point. Over the past several months I've been training and focusing on getting my diet dialed in. I've made some pretty good progress. I'm 5'8 168lbs ~12%. I"ve been cutting calories keeping it pretty clean lately.
Maybe one day down the road (30yr old) I'll look into this but I have a lot I can do natty till then. I miss that first cycle though, man lol. Still enjoy coming to the boards for inspiration.
I haven't done anything to this point. Over the past several months I've been training and focusing on getting my diet dialed in. I've made some pretty good progress. I'm 5'8 168lbs ~12%. I"ve been cutting calories keeping it pretty clean lately.
Maybe one day down the road (30yr old) I'll look into this but I have a lot I can do natty till then. I miss that first cycle though, man lol. Still enjoy coming to the boards for inspiration.
spastic_gramps
New member
One day I'm going to bring it up with my doctor. He is pretty opened minded and I've been with him for a while. He "gets" me lol. I'm not going to even think about it for a few years.
They had me on a huge dose of Prednisone for a long time to combat the Graph vs Host Disease (GVHD) post transplant. I was on tons of pain pills and other meds and basically seriously fucked up. Prednisone is a catabolic steroid. I had horrible wasting syndrome. But I wasn't getting better. I was addicted to the pain meds too.
It wasn't until I convinced by parents (my caregivers) to allow me to start smoking good herb (weed) that I started to get better. I was very frank with my doctors about what I was doing. It's a good drug therapy for cancer patients. Definitely not legal where I'm from. My transplant doctor at MD Anderson while taken a back was very cool about it. He would always come in after that and tell me. "You keep doing what you are doing!" with a big grin.
So, they know what kind of off the wall questions to expect from me.
If for nothing more than curiosity.
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I was diagnosed in Feb 05 with acute lymphoblastic leukemia. The treatment consisted of two years of chemo. Six months of intensive chemo and 18 months of maintenence chemo. I lost about 15 lbs during the two years. I was able to train during the maintenence phase, went back to work part time, had a ruptured colon at the 18 month mark. Surgery a colostmy bag for ten months, surgery to remove the bag, I was still able to train with the bag and maintain some normality. I had a remission of 11 months when the leukemia relapsed. I went into Dana Farber at 190 lbs in Jan 08. I spent 5 months on my back two intensive rounds of chemo, 9 rounds of radiation and Bone marrow transplant. In June 08 I left the hospital at a 130 lbs. A grand total of 75 lbs lost, and cancer weight loss is mostly muscle tissue, it is called cancer cachexia. As of now I weigh between 142 to 145 lbs. People who have transplants often have chronic graft vs host disease this is promulgated by Tumor Necrosis Factor-alpha or TNF-a a highly catabolic cytokinine. This prevents muscle protein synthesis/accrual. This is tough to take as I have been out of work for three years now and have no strength, energy or a life so to speak. I often refer to muscular development magazine with the article on Dennis Newman. According to Dennis, he received testosterone and anabolic steroids during his treatment phase. He then went on to compete in 4 pro bodybuilding competitions. This is unbelievable to me, with the use of anabolic steroids he was able to return to a normal life! Was he lucky or do anabolic steroids have any effect on leukemia????? Note search on pub med oxandrolone and cancer cachexia. There is some research suggesting that this can be used safely with some type of cancers. Nothing however on Bone Marrow transplants.
Background: Cachexia is a complex metabolic syndrome associated with many chronic or end-stage diseases, especially cancer, and is characterized by loss of muscle with or without loss of fat mass. The management of cachexia is a complex challenge that should address the different causes underlying this clinical event with an integrated or multimodal treatment approach targeting the different factors involved in its pathophysiology.
Aims and Objectives : The purpose of this article was to review the current medical treatment of cancer-related cachexia, in particular focusing on combination therapy and ongoing research.
Results : Among the treatments proposed in the literature for cancer-related cachexia, some proved to be ineffective, namely, cyproheptadine, hydrazine, metoclopramide, and pentoxifylline. Among effective treatments, progestagens are currently considered the best available treatment option for cancer-related cachexia, and they are the only drugs approved in Europe. Drugs with a strong rationale that have failed or have not shown univocal results in clinical trials so far include eicosapentaenoic acid, cannabinoids, bortezomib, and anti-TNF-alpha MoAb. Several emerging drugs have shown promising results but are still under clinical investigation (thalidomide, selective cox-2 inhibitors, ghrelin mimetics, insulin, oxandrolone, and olanzapine).
Conclusions : To date, despite several years of coordinated efforts in basic and clinical research, practice guidelines for the prevention and treatment of cancer-related muscle wasting are lacking, mainly because of the multifactorial pathogenesis of the syndrome. From all the data presented, one can speculate that one single therapy may not be completely successful in the treatment of cachexia. From this point of view, treatments involving different combinations are more likely to be successful.
Aims and Objectives : The purpose of this article was to review the current medical treatment of cancer-related cachexia, in particular focusing on combination therapy and ongoing research.
Results : Among the treatments proposed in the literature for cancer-related cachexia, some proved to be ineffective, namely, cyproheptadine, hydrazine, metoclopramide, and pentoxifylline. Among effective treatments, progestagens are currently considered the best available treatment option for cancer-related cachexia, and they are the only drugs approved in Europe. Drugs with a strong rationale that have failed or have not shown univocal results in clinical trials so far include eicosapentaenoic acid, cannabinoids, bortezomib, and anti-TNF-alpha MoAb. Several emerging drugs have shown promising results but are still under clinical investigation (thalidomide, selective cox-2 inhibitors, ghrelin mimetics, insulin, oxandrolone, and olanzapine).
Conclusions : To date, despite several years of coordinated efforts in basic and clinical research, practice guidelines for the prevention and treatment of cancer-related muscle wasting are lacking, mainly because of the multifactorial pathogenesis of the syndrome. From all the data presented, one can speculate that one single therapy may not be completely successful in the treatment of cachexia. From this point of view, treatments involving different combinations are more likely to be successful.
so the fact that AAS grow cells means that AAS users are more prone to these types of growths correct? that makes sense but what does everyone think?
a topic people do not want to discuss but lets be honest with ourselves. obviously smoking, drinking, poor lifestyle also increases cancer chances. a buddy of mine grew up near Cherynobl and when he came over to the US as a kid he ended up getting cancer at only 14 years old. so there are many factors in play
a topic people do not want to discuss but lets be honest with ourselves. obviously smoking, drinking, poor lifestyle also increases cancer chances. a buddy of mine grew up near Cherynobl and when he came over to the US as a kid he ended up getting cancer at only 14 years old. so there are many factors in play
