its not too hard on the liver. I took doxy while one 60mg of var with a bunch of liver supps and was fine, however just doxy isn't gonna do shit for your acne. If you have the acne without var it will intensify with var. It did for me and I was also taking tons of b5, and guggul. I finally had to end my cycle after 4 weeks. Luckily I was taking 60mg, eating big, and it was my first cycle so I manage to to gain about 7-8 lbs, but I wish I could find something to keep the acne away without having to resort to accutane.