holy shit that could be badNelson Montana said:They say 5 mgs of an oral is equal to a shot of hard liquer. It's a ballpark estimate, but it's all we've got.
Injectables much less so -- about 25 mgs equals a shot of liquer. Hardly a factor at all since administartion is less often.
So 50 mgs of an oral a day is comparable to 70 drinks a week as far as the liver perceives it.
Nelson Montana said:They say 5 mgs of an oral is equal to a shot of hard liquer. It's a ballpark estimate, but it's all we've got.
Injectables much less so -- about 25 mgs equals a shot of liquer. Hardly a factor at all since administartion is less often.
So 50 mgs of an oral a day is comparable to 70 drinks a week as far as the liver perceives it.
Originally Posted by nautica
Xenobiotic Metabolism
Xenobiotic Metabolism (basically drug metabolism, esp. breakdown) is carried out by enzymes, mainly in the liver, but also in the lung, kidneys, GI tract and skin. There are 3 phases in the in xenobiotic metabolism from the initial activation or deactivation to the final transport and clearance.
Phase 1 = functionalism or introducing a polar group to the molecule in order for the drug to be brought into cells and/or organelles.
Phase 2 = conjugation or coupling of a typically polar group to the molecule (the addition of the polar group will later be used in transport)
Phase 3 = Transport or altering localization of the molecule. i.e. Renal or biliary excretion.
Depending on the type of molecule (polar/nonpolar, ect...) the drug may or may not have to enter phase 1, it could start off in phase II, or III for that matter if it is a polar molecule and transportable. As we know, steroids are a class of large mostly non polar molecule, so they must be initiated in phase I.
Cytochrome P450 is the largest superfamily of Phase I enzymes, currently known. P450 has evolved along with humans, mainly for the purpose of endogenous steroid and arachidonic acid metabolism but as man began to partake in drugs, they assumed the role of exogenous drug metabolism and also exogenous steroids.
Fortunately, we also have other types of phase I enzymes such as Alcohol and aldehyde dehydrogenases. As alcohol is introduced into the body, it is brought into the cytosol, mainly in the parenchymal cells of the liver. At this time Alcohol dehydrogenase converts the alchohols to acetic aldehyde, which is perfectly fine. But, then the acetic aldehyde is shunted into the mitochondria, where it is converted to acetic acid, which is toxic. In this case, to the liver. At which time, it does its damage and moves on into Phase II metabolism.
So, at this time it does not appear that there would be a conflict. At least not on a cellular level. Right? Not neccessarily. For high levels of alcohol intake or alcoholics the Cytocrome P450 family also contributes to the phase I metabolism of alcohol, which, if you will recall, is what metabolizes steroids in phase I.
It does not appear that there is significant direct conflict in Phase II and III; however, as these drugs move through the metabolic phases they will cause necrosis on a gross scale, which will put an increased burden on the remaining tissues for the clearance of the drugs.
THIS IS A SIDE NOTE BUT IS OF EXTREME CLINICAL SIGNIFICANCE. PHASE I METABOLISM OF ACETAMINOPHEN WILL ACTIVATE 5% OF ACETAMINOPHEN, WHICH WILL ALSO HAVE TO BE CLEARED BYE CYTOCHROME P450. THERE HAVE BEEN NUMEROUS STUDIES SHOWING THE EXTREME DANGERS OF ACETAMINOPHEN BY ITSELF BUT IN RELATION TO ALCOHOL IT IS EVEN MORE SERIOUS AND IF STEROIDS ARE ADDED TO THE MIX IT IS EVEN MORE SERIOUS.
What does all of this mean. Basically, no one knows for sure. There are sooo many factors affecting xenobiotic metabolism: age, diet, health, gender, polymorphisms, species variation (animal testing problems), substrate competitive inhibition, enzyme stabilization or induction, routes of administration, ect......
This makes it also impossible for any one to tell you what will or will not hurt you, specifically. But, what I can tell you is that with each additional "vice" you add into your system you are raising your risk factors and you will be shortening your "natural" life expectancy (what I mean by natural life is excluding accidents, car wrecks, smoking, ect....). So it is up to you what you decide what you do with your life and what you choose to put in your body. But, you need to keep in mind that your view may be different now then it will be when you are 40 or 50 or 60. Who knows maybe if you live to be 70 and you have grand children running around, that might be worth more to you than 5 or 10 years of being JACKED.
BOTTOM LINE: I would suggest that if you are going to do steroids that you keep the 17 alpha-alkylated's to a minimum, although testosterone without any esters or 17 alpha-alkylated's, ect... must also be metabolized by the liver. The only, difference, and I repeat the only difference is the number of passes it takes through the liver. And, yes I know that aromatase converts test to estrogen yadda, yadda yadda, but this is also a "steroid" and at some point it will have to be broken down and removed from the body. And, if you must drink alcohol, then keep it also to a minimum. Don't binge and don't drink every night. And, most importantly, leave the FUCKING ACETAMINIPHEN alone. No matter what, don't take this drug (ibuprophen is also bad but not as bad) for any reason. Especially, if you have a hang over and your body has been clearing alcohol all night (plus the 300 mgs of Dianabol - methandrostenolone - you have built up in your system). Also, if you like to pop a few hydrocodones, while you drink, then just go straight for the oxycotin, at least, then your body will not have to metabolize all of the acetaminophen the government requires to be put into these drugs. But that is another story.
Hope that clears things up.
kasabian19 said:"They say 5 mgs of an oral is equal to a shot of hard liquer. It's a ballpark estimate, but it's all we've got.
Injectables much less so -- about 25 mgs equals a shot of liquer. Hardly a factor at all since administartion is less often.
So 50 mgs of an oral a day is comparable to 70 drinks a week as far as the liver perceives it."
Who says this? Scietific research/journal - please post. Or at least back up your claims.
so for a week would that be 7 days 50mg oral = 490 alcoholic drinks?ShowKidd said:seems about right to me.

kasabian19 said:"They say 5 mgs of an oral is equal to a shot of hard liquer. It's a ballpark estimate, but it's all we've got.
Injectables much less so -- about 25 mgs equals a shot of liquer. Hardly a factor at all since administartion is less often.
So 50 mgs of an oral a day is comparable to 70 drinks a week as far as the liver perceives it."
Who says this? Scietific research/journal - please post. Or at least back up your claims.
Tweakle said:Many people developed liver damage from a single Anadrol 50 - oxymetholone - ? who?
How exactly does injectable test affect the liver?
Tweakle said:I'm aware of the the hepatoxicity anadrol, which is why it's bizzare that anyone would claim liver damage after one pill. The theraputic, doctor prescribed dose is 5m per kilo, which would work out @ 500mg a day for an average sized lifter.
I've read studies that showed cysts, blood pools and other damage when the test subject rats took 150mg per kilo for months but I don't think even Palumbo is going to advocate that.
Anecdotally, I know my liver values were a little high after 2 months @ 100mg ED but hardly the equivalent of drinking a bottle of vodka daily for 8 weeks.
Two posts and already breaking balls, eh? We don't play the "my cut and paste study is bigger than your cut and paste study" here. I already mentioned it was an estimate. You have proof that's otherwise? Feel free to present it. If not, sit back, shut up, and learn from the vets here.
Have you got proof of this?
There is one single journal that links A-50 to cancer - in that case it was a 14 year old girl on Anadrol 300mg ED for 6 years. I can produce the journal if you like!
Sit down and shut up?
Hmmm, i have a degrees in chemistry and biology and have written a 1st class disseration regarding steroid chemistry etc..?
Just becuase i have few posts doesnt mean i dont know anything.
kasabian19 said:Two posts and already breaking balls, eh? We don't play the "my cut and paste study is bigger than your cut and paste study" here. I already mentioned it was an estimate. You have proof that's otherwise? Feel free to present it. If not, sit back, shut up, and learn from the vets here.
Have you got proof of this?
There is one single journal that links A-50 to cancer - in that case it was a 14 year old girl on Anadrol 300mg ED for 6 years. I can produce the journal if you like!
Sit down and shut up?
Hmmm, i have a degrees in chemistry and biology and have written a 1st class disseration regarding steroid chemistry etc..?
Just becuase i have few posts doesnt mean i dont know anything.
It's a matter of respect kid. You can offer a contrary point of view( which you still havn't done) but when you come off all confrontational and pissy with nothing else to offer other than being a dick, you're off to a bad start. I know that crap works on the kiddie boards like BB.com but not here. Too many vets.
I never said anything about cancer so I'm not sure where that's coming from. And please don't make multiple posts or have your friend with 7 posts egg you on.
You have a degree in chemistry and biology? Great, put it to good use and stop being an ass.
Nelson Montana said:They say 5 mgs of an oral is equal to a shot of hard liquer. It's a ballpark estimate, but it's all we've got.
Injectables much less so -- about 25 mgs equals a shot of liquer. Hardly a factor at all since administartion is less often.
So 50 mgs of an oral a day is comparable to 70 drinks a week as far as the liver perceives it.
Nelson Montana said:They say 5 mgs of an oral is equal to a shot of hard liquer. It's a ballpark estimate, but it's all we've got.
Injectables much less so -- about 25 mgs equals a shot of liquer. Hardly a factor at all since administartion is less often.
So 50 mgs of an oral a day is comparable to 70 drinks a week as far as the liver perceives it.
Nelson Montana said:They say 5 mgs of an oral is equal to a shot of hard liquer. It's a ballpark estimate, but it's all we've got.
Injectables much less so -- about 25 mgs equals a shot of liquer. Hardly a factor at all since administartion is less often.
So 50 mgs of an oral a day is comparable to 70 drinks a week as far as the liver perceives it.
r1 said:I have bloodwork for liver values after being on Nolvadex for a year at 20mg/day.
As Primordial Performance has pointed out, Nolvaldex - tamoxifen citrate - is indeed hard on your liver. I'm not sure how it rates vs oral gear like db0l or avar. I doubt it's in the same league as halotestin or I'd have died after 3 months.
R1
DJ_UFO said:yall a bunch of alcoholics
Nelson Montana said:500mgs a day? something's wrong with that.
Keep in mind, there's other damage from alcohol beyond the liver. There are people that drink up to a half bottle of booze a day for years with no apparent damage. And then...
kasabian19 said:Two posts and already breaking balls, eh? We don't play the "my cut and paste study is bigger than your cut and paste study" here. I already mentioned it was an estimate. You have proof that's otherwise? Feel free to present it. If not, sit back, shut up, and learn from the vets here.
Have you got proof of this?
There is one single journal that links A-50 to cancer - in that case it was a 14 year old girl on Anadrol 300mg ED for 6 years. I can produce the journal if you like!
Sit down and shut up?
Hmmm, i have a degrees in chemistry and biology and have written a 1st class disseration regarding steroid chemistry etc..?
Just becuase i have few posts doesnt mean i dont know anything.
Yea please post the article and your first class dissertation. Do they spell sheck it too? disseration? LMAO!!!!!!
702daswoll1 said:We are all going to die.. Im dying huge though!
halfcenturian said:I'm a recovered one. IMO alcohol kicks steroid ass on damage. But I drank for 25 years. My liver values are all normal noe. Your liver is a tough MoFo.
3 or 4 weeks on Anadrol 50 - oxymetholone - or Halo won't kill you. Alcohol will. Not even close
MichaelScott said:bump for mava
Mavafanculo said:thanks bro - i need to check this out
depends what type of alcohol you drink
the light color of the alcohol the easier it is on the liver
vodka = easier
whiskey = harder
This answer = retarded. Misinformation like this can have serious consequences.
"Clockwork" is actually correct. Not misinformation.
they affect the liver completely differently.
the damage from alcohol requires much more abuse over a longer period of time. damage from AAS can happen very rapidly and is very specific, oral steroids cause cholestasis (stopping bile flow from liver to gall bladder) which is easy to diagnose/prevent (change in stool/urine color) but can quickly cause liver damage if allowed to go unchecked. any liver disease that progresses to jaundice can easily be fatal.
On a gram for gram basis, I am sure the 17aa steroids are indeed harder on the liver.
Drinking spirits that has a darker colour like JD / Whiskey stresses the Liver far worse than Vodka, Rum(white), Gin etc. Of course all are bad. Fact !
they say 5 mgs of an oral is equal to a shot of hard liquer. It's a ballpark estimate, but it's all we've got.
Injectables much less so -- about 25 mgs equals a shot of liquer. Hardly a factor at all since administartion is less often.
So 50 mgs of an oral a day is comparable to 70 drinks a week as far as the liver perceives it.
I personally have never and I mean never heard of someone needing a liver transplant because of steriods. But I've heard of countless alcoholics needing one.
I cant imagine that this could be correct?posted by nelson montana
they say 5 mgs of an oral is equal to a shot of hard liquer. It's a ballpark estimate, but it's all we've got.
Injectables much less so -- about 25 mgs equals a shot of liquer. Hardly a factor at all since administartion is less often.
So 50 mgs of an oral a day is comparable to 70 drinks a week as far as the liver perceives it.
So 50 mgs of an oral a day is comparable to 70 drinks a week as far as the liver perceives it.
Anabolic-androgenic steroids for alcoholic liver disease
hmmmmmm this is for people who already had fucked up alcoholic liver disease. Then they gave them injectable steroids to see if it would cause any more problems. Like OMG nothing happen???? YOu are kidding me
Anabolic-androgenic steroids for alcoholic liver disease
But lets face it. If you are taking oral steroids you run the risk of sudden death at any moment. I am sorry to be the one to say this but its true. Yes its not all the time this happens but the odds of it happening to you are a lot greater then winning the lottery and a lot greater then you think.. Like maybe 1 out of 500k people who take oral steroids will die because of taking them. When you really stop and think about this its scary.. I think every single person should take time to sit down and think real hard about that before they do use a oral steroid.
Death due to Liver Failure Following the Use of Methandrostenolone
If most people were to drink a 26oz bottle of vodka every day for a month they would have some degree of kidney or liver failure or worse. Unfortunately for me I was almost there from 20, 7% alc. drinks a day for three weeks during a college binge years ago.
Makes me think I should flush the dbol I have down the toilet and be nice to my liver.
I know nothing about doing juice and too much about drinking.
I have been convinced by the experienced guys here to stick with only test for my first few cycles - makes more and more sense the more I think about it.
Thanks.
But lets face it. If you are taking oral steroids you run the risk of sudden death at any moment. I am sorry to be the one to say this but its true. Yes its not all the time this happens but the odds of it happening to you are a lot greater then winning the lottery and a lot greater then you think.. Like maybe 1 out of 500k people who take oral steroids will die because of taking them. When you really stop and think about this its scary.. I think every single person should take time to sit down and think real hard about that before they do use a oral steroid.
Death due to Liver Failure Following the Use of Methandrostenolone
But lets face it. If you are taking oral steroids you run the risk of sudden death at any moment. I am sorry to be the one to say this but its true. Yes its not all the time this happens but the odds of it happening to you are a lot greater then winning the lottery and a lot greater then you think.. Like maybe 1 out of 500k people who take oral steroids will die because of taking them. When you really stop and think about this its scary.. I think every single person should take time to sit down and think real hard about that before they do use a oral steroid.
Death due to Liver Failure Following the Use of Methandrostenolone
71 year old woman taking 10 mgs of dbol for 14 months in the 60s is not proof of anything except a retarded doctor...
How about the alcohol and steroid together ? 1 mouth i drinked alcohol (martini bianco) , with winstrol 30 mg (not everyday) now i am afraid to go to doctori was stupid...
Facts that make me believe alcohol is worse.
1) I do not drink at all. (Stopped in 2003)
2) I'm on my fourth cycle
600mg of sust a week for 15 weeks
37.5mg of dbol for 40 days
I always have my blood work done and I'm always perfect. Liver is doing great! Nothing wrong with me according to my Dr. The part that pisses my girl off is that my cholesterol is so good. He tells me that I'm the only person he knows that he will give the "ok" to eat at micdoalds and taco-bell.
Sent from my ADR6350 using EliteFitness
Just curious if alcohol is more liver toxic then some steroids...Dunno if this has been done but havent seen it
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