Topical 1-AD
Rotty:
I get gas on 1-AD even with just 1 capsule 3 times per day so I've made a topical preparation. I will start using it this week.
In making the topical, I wrote Pat Arnold (inventor of 1-AD) and asked his advice. He was very helpful and replied several times as I had questions. He said if you use DMSO use 75% dmso and 25% distilled water. (your 70% solution should be fine).
Or, he said use 80% grain alcohol (Everclear) and 20% isopropyl myristate (IPM: a penetration enhancer without the smell of DMSO).
I have DMSO, but decided to go the IPM route. If you live work with other humans, you won't like the way DMSO makes you smell.
Patrick suggested a 50mg 1-AD to 1 ml of solution concentration. So, I dumped the contents of 125 1-AD pills into a solution of 200ml grain alcohol and 50ml IPM. I stirred it up several times and left it for several hours. After a while, there was some settling so I carefully tipped the bottle and poured off the top into another bottle (this is called decanting), leaving the sediment on the bottom of the first bottle which I threw away. Patrick said this sediment is just the insoluble binder all manufacturers add to their capsules. I decanted the solution about 3 times and am now left with about 8 oz of topical 1-AD in a 50mg/ml solution. Total cost was $90 (about the price of a bottle of Norandrosol) from 2 bottles of 1-AD $83 plus 200ml of grain alcohol $4 plus 50ml of IPM $2. You can get the IPM from
www.lemelang.com or
www.reneal.com.
Patrick said to try to apply 300 mg to 600 mg twice per day after showering if you can. Spreading it out as far as possible. Spray bottle is best but you need to measure the output of each spray. That would be 6-12 ml. I'll probably apply the smaller amount at first, showering only in the morning.
When Ergopharm gets production up, he'll probably offer a topical version much like this. Perhaps it will be cheaper. I hope so.