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You\'re reading it here first in this Platinum Member exclusive. MGF (Mechano Growth Factor) an IGF-1 variant, produced a 20% increase in the weight of the injected muscle within 2 weeks due to an increase in the size of the muscle fibers!
Enjoy this Platinum Member exclusive article from my friend and EliteFitness.com Platinum Member, Anthony Roberts!
When Growth Hormone (GH) was first introduced to the bodybuilding world, everyone had high hopes. Those hopes fizzled out pretty quickly, as bodybuilders experimented with absurdly low dosages (2iu/Every other Day) necessitated by its high cost. As growth hormone costs fell due to more efficient manufacturing processes (i.e. it was no longer being extracted from cadavers), bodybuilders were able to use more of it, and subsequently began to see better results from it. We saw the same phenomenon with the anabolic mediator of GH, Insulin-like Growth Factor-1 (IGF-1) and later with its analogue LR3IGF-1.
Now, we’ve seen the emergence of yet another compound further down the hormonal cascade: Mechano Growth Factor. As you probably know, skeletal muscle responds to resistance training (or any mechanical overload) by increasing its size (hopefully). If you “detrain” that muscle (i.e. don’t use it regularly), it atrophies and gets smaller.
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Similarly, when you are in your teens and early twenties GH and IGF-1 levels are high, and as you age, those levels are lowered naturally. And if you’ve been playing along at home, you’re probably figuring out that GH and IGF-1 are pieces of the hormonal puzzle that results in this muscle growth (or loss). These growth factors are produced in the liver and other areas, but also in skeletal tissue in response to training induced damage. Now, pay attention, because this is the important part - growth factors produced within the muscle as a response to resistance training likely play a major role in repair, adaptation, hypertrophy (muscle growth), and also ageing.
Scientists have discovered that many of Growth Hormones anabolic and regenerative effects are actually mediated by Insulin like growth factor 1. Thus, the next logical step for bodybuilders - if bodybuilders can be said to follow some kind of logic - was to start experimenting with IGF-1 and later with the more potent version, LR3IGF-1.
The thing is, we now know that IGF-1 actually exists in the body in multiple isoforms. The isoform that seems most useful to us, differs slightly from that which is produced in the liver (IGF-1Ea), and appears to be the significantly more anabolic of the two we’re looking at here (i.e. that which is produced in the liver vs. that which is produced in the muscle). This is because it is hyper-sensitive to the signals produced by local muscular damage induced by resistance training. This more anabolic isoform of IGF-1 is called “IGF-1Ec” or mechano growth factor (MGF).
That’s right, MGF, the mysterious hormone that seems to be only whispered in e-mails and PMs on the ‘net is actually just another variant of IGF-1. Yeah, if you’ve used IGF-1 or even Growth Hormone, then technically, you’ve already been taking advantage of MGF. In fact, if you work out with weights, you’ve been producing your own MGF, as this particular isoform of IGF-1 is only detected in normal muscle after mechanical stimulation (such as resistance training). Remember, MGF is just a name for the particular type of IGF-1 which is produced locally in the muscle as part of the anabolic repair response to resistance training.
Platinum Members, here\'s a link to the rest of the article. Including how MGF works, MGF studies in humans and animals, anecdotal experiences from athletes, and dosage suggestions from other athletes. Find the rest of the article and discuss it here.
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My Review of Tom Venuto\'s Burn The Fat, Feed The Muscle - just in time for summer!
With Burn the Fat, Feed The Muscle, Tom Venuto, respected professional bodybuilder, personal trainer and nutritionist, has not merely pumped out yet another diet and weight loss publication into an already over-saturated market. No, Mr. Venuto\'s Burn the Fat can be more accurately described as a weight loss manifesto. It is quite simply one of the most complete, detailed, and precise guides to fat loss that I\'ve ever seen.
What makes it so much different than other weight loss publications on the market?
Mostly, it\'s the attention allotted to each and every element of successful weight loss. It\'s the thorough dispelling of myths and fallacies. It\'s the complete attention to detail, the dotting of every "i" and the crossing of every "t". Seriously -- by reading Burn the Fat, Feed The Muscle, you\'ll learn more than the contents of an entire bookshelf of mainstream weight loss publications down at your local bookstore.
Most of you will ask -- is this a low carb diet? A high protein diet? A high fat diet? What\'s the ratio of carbs to proteins, and so on.
The truth is that in Burn the Fat, there is no one "perfect" ratio of carbs to fats to proteins. And Burn the Fat is neither a high protein diet, or a low carb diet. That\'s because you will determine your own ideal macronutrient ratio by analyzing your body type (are you an endomorph, ectomorph, or mesomorph?), determining your BMR (Basal Metabolic Rate, or the amount of "maintenance" calories your body requires daily) and activity rate, and assessing your own tolerance to carbohydrates. This makes sense -- each one of us is a unique individual, and no one diet or macronutrient ratio will work for everyone. Tom says the secret of the magical nutrient ratio is that there is no magic nutrient ratio.
Sounds good to me.
This might all sound impossibly complicated right now, but Tom does a nice job of explaining everything thoroughly.
One of my favorite chapters in the book is the first one, "How to Set Powerful, Compelling Goals That Will Propel You Forward and Charge You Up with Unstoppable Motivation". Here Tom illustrates that not only is he a world class drug free bodybuilder, but a pretty darn good psychologist too. There\'s a great quote here from Vince Lombardi...
"The dictionary is the only place success comes before work. Hard work is the price we must all pay for success".
.. that does a nice job of setting the stage for the entire publication. I really like this chapter, and even stopped to make note of my own goals. After this, Tom takes us into the complete mechanics of weight loss at full speed. Occasionally though, there\'s so much material that it becomes a tad overwhelming. For example...
In Chapter 3, "Body Composition: How to Determine Your Fat to Muscle Ratio", Tom explains the importance of accurately measuring your body fat composition, and why it is the most accurate indicator of health and fitness. There\'s nothing wrong with this, of course -- it\'s completely true and one of the foundations of getting your program off on the right foot. The only problem is that it takes him 15 pages to do so -- this chapter also contains a ton of additional information (like detailed examinations of more popular, less effective methods of measuring body composition) that the average dieter simply doesn\'t care to know.
If there is a fault to Burn the Fat, it is that there is so much information here. But otherwise, it\'s all good, and everything from eating to exercise is covered in detail.
Who will benefit most from Tom Venuto\'s Burn the Fat?
In the broadest sense, anyone and everyone who needs to lose weight. Bodybuilders, avid readers, especially motivated individuals and information gatherers will love this volume. With that said, however, I must also say this...
Anyone looking for a candy-coated solution to weight loss, anyone looking to be told fairy-tales, and anyone looking for the sort of "solution" offered by the likes of body wraps, apple cider vinegar and negative calorie foods, might be best advised to steer clear of Burn the Fat. Tom doesn\'t beat around the bush. There are no "30 lbs. in 30 days" miracles at work here. It\'s all about intelligent eating choices, planning, and hard work. As Tom himself says...
Burn the Fat is simple, but it\'s not easy.
I might caution that for weight loss newcomers, Burn the Fat is not really all that simple. This is a fairly intense volume (although well written and easy to follow), that will require a significant time commitment just to get through it, cover to digital cover. And read it cover to cover you must.
Burn the Fat is not something you can download and read in an evening (plus, it comes with about half a dozen bonus files). If you had trouble struggling through the first few chapters of Barry Sears\' Enter the Zone, or The Atkins Diet, you\'ll likely find Burn the Fat a little tedious. That doesn\'t mean, of course, that you shouldn\'t attempt to read Burn the Fat. Quite the opposite, I heartily recommend that you do so. But I suggest you pull out your daytimer or PDA, and find a half dozen or so hour-slots that you can commit entirely to this publication. Otherwise, you\'ll be wasting your time and your money.
Aesthetically, Burn the Fat is a clean and professionally formatted PDF file. It\'s a little on the plain side, but that makes it an ideal volume for printing and reading in the comfort of a favorite chair (something I highly recommend, by the way).
Initially, I thought Tom Venuto\'s Burn the Fat was priced a little on the high side -- $37 is a fair chunk of money for a PDF-formatted ebook. However, now that I\'ve read it, I no longer feel that way. As with any informative publication, you\'re not really paying for the materials used to compile the document, but the information contained therein.
Bottom line?
Burn the Fat and its accompanying bonus volumes is well worth the $37 price tag, probably even twice that amount... provided you can make the commitment to reading and implementing it. If you are serious about losing weight, and are sick and tired of "spinning your wheels" and going nowhere, I highly recommend this publication.
Here\'s a link to learn more about Tom Vento\'s Burn the Fat!
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